Therapeutic Potential of Saffron (Crocus sativus L.) in Ischemia Stroke

Evidence-based Complementary and Alternative Medicine - Tập 2021 - Trang 1-8 - 2021
Shakiba Azami1, Zahra Shahriari2, Samira Asgharzade3, Tahereh Farkhondeh4, Mahmood Sadeghi4, Fatemeh Ahmadi5, Mohammad Mahdi Vahedi6, Fatemeh Forouzanfar7,8
1Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
2Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
4Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran
5Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
6Department of Pharmacology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
7Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
8Neuroscience research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Tóm tắt

Stroke is the second leading cause of death and a main cause of disability worldwide. The majority (approximately 80%) of strokes are ischemic. Saffron (Crocus sativus L.) has been considered for medicinal purposes since ancient times. Pharmacological effects of saffron are attributed to the presence of crocin, crocetin, picrocrocin, and safranal. In the present review, we summarized the reported neuroprotective effects of saffron and its active constituents against cerebral ischemia stroke. Saffron and its components exert its beneficial effects as an antioxidant, anti-inflammatory, and antiapoptotic agent though inhibition of biochemical, inflammatory, and oxidative stress markers. Taken together, this review indicates that saffron and its ingredients could be a potent candidate in the process of new drug production for the treatment of ischemia stroke.

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Evidence-based Complementary and Alternative Medicine

Tập 2021

1-8

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