Therapeutic Effect of Vitamin D3 in a Rat Diffuse Axonal Injury Model

Journal of International Medical Research - Tập 33 Số 1 - Trang 90-95 - 2005
Ümit Ali Malçok1, Gökşin Şengül1, Hakan Hadi Kadıoğlu1, Aydin Ih1
1Department of Neurosurgery. Medical School. Ataturk University. Erzurum. Turkey

Tóm tắt

We investigated the therapeutic effect of vitamin D3 in a rat diffuse axonal injury model. A total of 60 male Sprague-Dawley rats weighing 175 − 200 g were anaesthetized and subjected to head trauma using Marmarou's impact-acceleration model. The rats were then separated into two groups; one group was treated with vitamin D3 and the other with saline for up to 4 days after the head trauma. Rats from both groups were killed 1, 3 or 8 days post-injury. The brains were examined histopathologically and scored according to the level of neuronal, vascular and axonal damage. There were no significant differences between the groups after 1 or 3 days, but evaluation after 8 days revealed a significant improvement in the group treated with vitamin D3. Our data indicate that vitamin D3 has a beneficial effect in diffuse axonal injury and may be useful in the management of this condition.

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Journal of International Medical Research

Tập 33 Số 1

90-95

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