The various regulatory functions of long noncoding RNAs in apoptosis, cell cycle, and cellular senescence

Journal of Cellular Biochemistry - Tập 123 Số 6 - Trang 995-1024 - 2022
Mohammad Heydarnezhad Asl1, Faezeh Pasban Khelejani2, Seyedeh Zahra Bahojb Mahdavi3, Ebrahim Sakhinia4, Asiyeh Jebelli5,6, Ahad Mokhtarzadeh7
1Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
2Department of Cell and Molecular Biology, Faculty of Basic Sciences, University of Maragheh, Maragheh, Iran
3Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran
4Department of Medical Genetics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran
5Department of Biological Science, Faculty of Basic Science, Higher Education Institute of Rab-Rashid, Tabriz, Iran
6Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
7Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Tóm tắt

AbstractLong noncoding RNAs (lncRNAs) are a group of noncoding cellular RNAs involved in significant biological phenomena such as differentiation, cell development, genomic imprinting, adjusting the enzymatic activity, regulating chromosome conformation, apoptosis, cell cycle, and cellular senescence. The misregulation of lncRNAs interrupting normal biological processes has been implicated in tumor formation and metastasis, resulting in cancer. Apoptosis and cell cycle, two main biological phenomena, are highly conserved and intimately coupled mechanisms. Hence, some cell cycle regulators can influence both programmed cell death and cell division. Apoptosis eliminates defective and unwanted cells, and the cell cycle enables cells to replicate themselves. The improper regulation of apoptosis and cell cycle contributes to numerous disorders such as neurodegenerative and autoimmune diseases, viral infection, anemia, and mainly cancer. Cellular senescence is a tumor‐suppressing response initiated by environmental and internal stress factors. This phenomenon has recently attained more attention due to its therapeutic implications in the field of senotherapy. In this review, the regulatory roles of lncRNAs on apoptosis, cell cycle, and senescence will be discussed. First, the role of lncRNAs in mitochondrial dynamics and apoptosis is addressed. Next, the interaction between lncRNAs and caspases, pro/antiapoptotic proteins, and also EGFR/PI3K/PTEN/AKT/mTORC1 signaling pathway will be investigated. Furthermore, the effect of lncRNAs in the cell cycle is surveyed through interaction with cyclins, cdks, p21, and wnt/β‐catenin/c‐myc pathway. Finally, the function of essential lncRNAs in cellular senescence is mentioned.

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Journal of Cellular Biochemistry

Tập 123 Số 6

995-1024

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