Chất đạm virus chọn lọc khối u apoptin tiêu diệt hiệu quả tế bào ung thư đường mật ở người

De Groen PC, Gores GJ, laRusso NF, Gunderson LL, Nagorney DM (1999) Biliary tract cancers. N Engl J Med 341:1368–1378 Byrnes V, Afdhal N (2002) Cholangiocarcinoma of the hepatic hilum (klatskin tumor). Curr Treat Options Gastroenterol 5:87–94 Kawarada Y, Yamagiwa K, Das BC (2002) Analysis of the relationships between clinicopathologic factors and survival time in intrahepatic cholangiocarcinoma. Am J Surg 183:679–685 Valverde A, Bonhomme N, Farges O, Sauvanet A, Flejou JF, Belghiti J (1999) Resection of intrahepatic cholangiocarcinoma: a Western experience. J Hepatobiliary Pancreat Surg 6:122–127 Cheng JL, Bruno MJ, Bergman JJ, Rauws EA, Tytgat GN, Huibregtse K (2002) Endoscopic palliation of patients with biliary obstruction caused by nonresectable hilar cholangiocarcinoma: efficacy of self-expandable metallic Wallstents. Gastrointest Endosc 56:33–39 Crane CH, Macdonald KO, Vauthey JN, Yehuda P, Brown T, Curley S, Wong A, Delclos M, Charnsangavej C, Janjan NA (2002) Limitations of conventional doses of chemoradiation for unresectable biliary cancer. Int J Radiat Oncol Biol Phys 53:969–974 Price P (2001) Cholangiocarcinoma and the role of radiation and chemotherapy. Hepatogastroenterology 48:51–52 Dive C (1997) Avoidance of apoptosis as a mechanism of drug resistance. J Intern Med Suppl 740:139–145 Hannun YA (1997) Apoptosis and the dilemma of cancer chemotherapy. Blood 89:1845–1853 Makin G, Dive C (2001) Apoptosis and cancer chemotherapy. Trends Cell Biol 11:S22–S26 Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70 Aas T, Borresen AL, Geisler S, Smith-Sorensen B, Johnsen H, Varhaug JE, Akslen LA, Lonning PE (1996) Specific p53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat Med 2:811–814 Findley HW, Gu L, Yeager AM, Zhou M (1997) Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. Blood 89:2986–2993 Noteborn MHM, Danen-van Oorschot AAAM, Van der Eb AJ (1998) The apoptin gene of chicken anemia virus in the induction of apoptosis in human tumorigenic cells and in gene therapy of cancer. Gene Ther Mol Biol 1:399–406 Danen-van Oorschot AAAM, Van der Eb AJ, Noteborn MHM (2000) The chicken anemia virus-derived protein apoptin requires activation of caspases for induction of apoptosis in human tumor cells. J Virol 74:7072–7078 Zhuang SM, Shvarts A, Jochemsen AG, van Oorschot AA, van der Eb AJ, Noteborn MHM (1995) Differential sensitivity to Ad5 E1B-21kD and Bcl-2 proteins of apoptin-induced versus p53-induced apoptosis. Carcinogenesis 16:2939–2944 Pietersen AM, van der Eb MM, Rademaker HJ, van den Wollenberg DJ, Rabelink MJ, Kuppen PJ, van Dierendonck JH, van Ormondt H, Masman D, van de Velde CJ, van der Eb AJ, Hoeben RC, Noteborn MH (1999) Specific tumor-cell killing with adenovirus vectors containing the apoptin gene. Gene Ther 6:882–892 Danen-van Oorschot AAAM, van der Eb AJ, Noteborn MHM (1999) Bcl-2 stimulates apoptin-induced apoptosis. Adv Exp Med Biol 457:245–249 Danen-van Oorschot AAAM, Zhang Y, Erkeland SJ, Fischer DF, van der Eb AJ, Noteborn MHM (1999) The effect of Bcl-2 on apoptin in ‘normal’ vs transformed human cells. Leukemia 13 [Suppl 1]:S75–S77 Zhuang SM, Shvarts A, van Ormondt H, Jochemsen AG, van der Eb AJ, Noteborn MHM (1995) Apoptin, a protein derived from chicken anemia virus, induces p53-independent apoptosis in human osteosarcoma cells. Cancer Res 55:486–489 Danen-van Oorschot AAAM, Fischer DF, Grimbergen JM, Klein B, Zhuang S, Falkenburg JH, Backendorf C, Quax PH, van der Eb AJ, Noteborn MHM (1997) Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. Proc Natl Acad Sci U S A 94:5843–5847 Zhang Y-H, Leliveld SR, Kooistra K, Molenaar C, Rohn JL, Tanke HJ, Abrahams JP, Noteborn MHM (2003) Recombinant apoptin multimers kill tumor cells but are nontoxic and epitope-shielded in a normal-cell-specific fashion. Exp Cell Res 289:36–46 Shimizu Y, Demetris AJ, Gollin SM, Storto PD, Bedford HM, Altarac S, Iwatsuki S, Herberman RB, Whiteside TL (1992) Two new human cholangiocarcinoma cell lines and their cytogenetics and responses to growth factors, hormones, cytokines or immunologic effector cells. Int J Cancer 52:252–260 Knuth A, Gabbert H, Dippold W, Klein O, Sachsse W, Bitter-Suermann D, Prellwitz W, Meyer zum Buschenfelde KH (1985) Biliary adenocarcinoma. Characterisation of three new human tumor cell lines. J Hepatol 1:579–596 Fallaux FJ, Bout A, van der Velde I, van den Wollenberg DJ, Hehir KM, Keegan J, Auger C, Cramer SJ, van Ormondt H, van der Eb AJ, Valerio D, Hoeben RC (1998) New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses. Hum Gene Ther 9:1909–1917 Fallaux FJ, Kranenburg O, Cramer SJ, Houweling A, van Ormondt H, Hoeben RC, van der Eb AJ (1996) Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Ther 7:215–222 Menke AL, Shvarts A, Riteco N, van Ham RC, van der Eb AJ, Jochemsen AG (1997) Wilms’ tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor. Cancer Res 57:1353–1363 Steegenga WT, Van Laar T, Shvarts A, Terleth C, Van der Eb AJ, Jochemsen AG (1995) Distinct modulation of p53 activity in transcription and cell cycle regulation by the large (54 kDa) and the small (21 kDa) adenovirus E1B proteins. Virology 212:543–554 van den Heuvel SJ, van Laar T, Kast WM, Melief CJ, Zantema A, van der Eb AJ (1990) Association between the cellular p53 and the adenovirus 5 E1B-55kd proteins reduces the oncogenicity of Ad-transformed cells. EMBO J 9:2621–2629 Eb MM van der, Pietersen AM, Speetjens FM, Kuppen PJ, van de Velde CJ, Noteborn MH, Hoeben RC (2002) Gene therapy with apoptin induces regression of xenografted human hepatomas. Cancer Gene Ther 9:53–61 Graham FL, Prevec L (1995) Methods for construction of adenovirus vectors. Mol Biotechnol 3:207–220 Caca K, Feisthammel J, Klee K, Tannapfel A, Witzigmann H, Wittekind C, Mossner J, Berr F (2002) Inactivation of the INK4a/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines. Int J Cancer 97:481–488 Yazumi S, Ko K, Watanabe N, Shinohara H, Yoshikawa K, Chiba T, Takahashi R (2000) Disrupted transforming growth factor-beta signaling and deregulated growth in human biliary tract cancer cells. Int J Cancer 86:782–789 Okuda K, Nakanuma Y, Miyazaki M (2002) Cholangiocarcinoma: recent progress. II Molecular pathology and treatment. J Gastroenterol Hepatol 17:1056–1063 Moll UM, Erster, S, Zaika A (2001) p53, p63 and p73–slos, alliances and feuds among family members. Biochim Biophys Acta 1552:47–59 Pederson LC, Vickers SM, Buchsbaum DJ, Kancharla SR, Mayo MS, Curiel DT, Stackhouse MA (1998) Combined cytosine deaminase expression, 5-fluorocytosine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells. J Gastrointest Surg 2:283–291 Pederson LC, Buchsbaum DJ, Vickers SM, Kancharla SR, Mayo MS, Curiel DT, Stackhouse MA (1997) Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo. Cancer Res 57:4325–4332 Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen GS (1998) Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. Biochemistry 37:10757–10765 Stennicke HR, Ryan CA, Salvesen GS (2002) Reprieval from execution: the molecular basis of caspase inhibition. Trends Biochem Sci 27:94–101 Van Cruchten S, Van Den BW (2002) Morphological and biochemical aspects of apoptosis, oncosis and necrosis. Anat Histol Embryol 31:214–223 Hirsch T, Marchetti P, Susin SA, Dallaporta B, Zamzami N, Marzo I, Geuskens M, Kroemer G (1997) The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. Oncogene 15:1573–1581 McCarthy NJ, Whyte MK, Gilbert CS, Evan GI (1997) Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J Cell Biol 136:215–227 Peeters MJ, Patijn GA, Lieber A, Meuse L, Kay MA (1996) Adenovirus-mediated hepatic gene transfer in mice: comparison of intravascular and biliary administration. Hum Gene Ther 7:1693–1699 Cheifetz RE, Davis NL, Owen DA (1996) An animal model of benign bile-duct stricture, sclerosing cholangitis and cholangiocarcinoma and the role of epiderma growth factor receptor in ductal proliferation. Can J Surg 39:193–197