The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS‐III): a research program striving to improve blood donor and transfusion recipient outcomes

Transfusion - Tập 54 Số 3pt2 - Trang 942-955 - 2014
Steven Kleinman1, Michael P. Busch2,3, Edward L. Murphy2,4, Hua Shan5, Paul M. Ness6,7, Simone A. Glynn8
1Department of Pathology University of British Columbia Victoria British Columbia Canada
2Blood Systems Research Institute, San Francisco, California
3Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California
4Department of Laboratory Medicine and Epidemiology/Biostatistics University of California at San Francisco San Francisco California
5Department of Pathology, The Johns Hopkins University, Baltimore, Maryland
6Department of Pathology and Medicine The Johns Hopkins University Baltimore Maryland
7Department of Transfusion Medicine Johns Hopkins Medical Institutions Baltimore Maryland
8Department of Transfusion Medicine and Cellular Therapeutics Branch National Heart, Lung, and Blood Institute National Institutes of Health Bethesda Maryland

Tóm tắt

BackgroundThe Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III) is a 7‐year multicenter transfusion safety research initiative launched in 2011 by the National Heart, Lung, and Blood Institute.Study Design and MethodsThe domestic component involves four blood centers, 12 hospitals, a data coordinating center, and a central laboratory. The international component consists of distinct programs in Brazil, China, and South Africa, which involve US and in‐country investigators.ResultsREDS‐III is using two major methods to address key research priorities in blood banking and transfusion medicine. First, there will be numerous analyses of large “core” databases; the international programs have each constructed a donor and donation database while the domestic program has established a detailed research database that links data from blood donors and their donations, the components made from these donations, and data extracts from the electronic medical records of the recipients of these components. Second, there are more than 25 focused research protocols involving transfusion recipients, blood donors, or both that either are in progress or are scheduled to begin within the next 3 years. Areas of study include transfusion epidemiology and blood utilization, transfusion outcomes, noninfectious transfusion risks, human immunodeficiency virus–related safety issues (particularly in the international programs), emerging infectious agents, blood component quality, donor health and safety, and other donor issues.ConclusionsIt is intended that REDS‐III serve as an impetus for more widespread recipient and linked donor–recipient research in the United States as well as to help assure a safe and available blood supply in the United States and in international locations.

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Transfusion

Tập 54 Số 3pt2

942-955

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