The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma
Tóm tắt
Eosinophils are bone marrow-derived granulocytes known to have an imperative role in tissue inflammation. The mechanism of tumour-associated tissue eosinophilia (TATE) in head and neck cancers is however not well understood, and its role as a prognosticator is under evaluation. The aim of this study was to evaluate the association of TATE with factors associated with head and neck cancer and to assess its role as a prognostic marker in such patients.
102 males and 24 females comprised the study population, and 34.9% of which were in the age group of 41 to 50 years. Amongst these 126 patients, most (37.3%) presented in stage III followed by stage IV (28.6%). 29.4% had well-differentiated SCC, 55.6% had moderately differentiated SCC, and 15% were diagnosed with poorly differentiated SCC. 42.8% had TATE grade II, followed by grade III (29.4%) and grade I (27.8%). Correlation studies showed that factors significantly associated with TATE were age, site and tumour differentiation. While 45.7% poorly differentiated tumours showed grade I eosinophilia, 51.4% of well-differentiated tumours had grade III TATE.
TATE showed a highly significant association with tumour differentiation, suggestive of eosinophils partaking a tumouricidal role. This association may be utilised as a convenient early prognosticator for head and neck cancers and should be made a regular feature of biopsy reports. Furthermore, it may be utilised in planning and adopting appropriate treatment modalities in malignancies predicted to have an aggressive course.
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Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61(2):69-90. https://doi.org/10.3322/caac.20107. Epub 2011 Feb 4. Erratum in: CA Cancer J Clin. 2011 Mar-Apr;61(2):134. PMID: 21296855
DeSantis C, Naishadham D, Jemal A (2013) Cancer statistics for African Americans 2013. CA Cancer J Clin 63:151
Leighton SEJ, Teo JGC, Leung SF, Cheung AYK, Lee JCK, Hassel CAV (1996) Prevalence and prognostic significance of tumor-associated tissue eosinophilia in nasopharyngeal carcinoma. Cancer. 77:436–440
Dorta RG, Landman G, Kowalski LP, Lauris JRP, Latorre MRDO, Oliveira DT (2002) Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas. Histopathology. 41(2):152–157
Oliveira DT, Tjioe KC, Assao A, Faustino SES, Carvalho AL, Kowalski GL, Paulo L (2009) Tissue eosinophilia and its association with tumoral invasion of oral cancer. Int J Surg Pathol 17(3):244–249
Bhan C, Purohit K, Purohit JP, Singh AP, Singh B, Selvaraj S, Pandey M, Kumar V (2016) Tumour associated tissue eosinophilia as a prognostic indicator in squamous cell carcinoma of upper aerodigestive tract. International Journal of Otolaryngology and Head & Neck Surgery 5:54–58
Ohashi Y, Ishibashi S, Suzuki T, Shineha R, Moriya T, Satomi S, Sasano H (2000) Significance of tumor associated tissue eosinophilia and other inflammatory cell infiltrate in early esophageal squamous cell carcinoma. Anticancer Res 20:3025–3030
Ishibashi S, Ohashi Y, Suzuki T, Miyazaki S, Moriya T, Satomi S, Sasano H (2006) Tumor-associated tissue eosinophilia in human esophageal squamous cell carcinoma. Anticancer Res 26:1419–1424
Lowe D, Fletcher CD (1984) Eosinophilia in squamous cell carcinoma of the oral cavity, external genitals and anus- clinical correlations. Histopathology. 8(4):627–632
Goldsmith MM, Belchis DA, Cresson DH, Merrit WD, Askin FB (1992) The importance of eosinophils in head and neck cancer. Otolaryngol Head Neck Surg 106(1):27–33
Horiuchi K, Mishima K, Ohsawa M, Sugimura M, Aozasa K (1993) Prognostic factors for well differentiated squamous cell carcinoma in the oral cavity with emphasis on immunohistochemical evaluation. J Surg Oncol 53(2):92–96
Van Driel WJ (1996) Tumour-associated eosinophilic infiltrate of cervical cancer is indicative for a less effective immune response. Hum Pathol 27(9):904–911
Wong DTW, Bowen SM, Elovic A, Gallagher GT, Weller PF (1999) Eosinophilia abalation and tumour development. Oral Oncol 35(5):496–501
Oliveira DT, Biassi TP, Faustino SES, Carvalho AL, Landman G, Kowalski LP (2012) Eosinophils may predict occult lymph node metastasis in early oral cancer. Clin Oral Investig 16:1523–1528
Jain M, Kasetty S, Khan S, Jain NK (2014) Tissue eosinophilia in head and neck squamous neoplasia: an update. Exp Oncol 36(3):157-161. PMID: 25265347
Looi LM (1987) Tumor-associated tissue eosinophilia in nasopharyngeal carcinoma. A pathologic study of 422 primary and 138 metastatic tumors. Cancer. 59:466–470
Thompson AC, Bradley PJ, Griffin NR (1994) Tumor-associated tissue eosinophilia and long-term prognosis for carcinoma of the larynx. Am J Surg 168(5):469-471. https://doi.org/10.1016/s0002-9610(05)80102-3. PMID: 7977976
Said M, Wiseman S, Yang J, Alrawi S, Douglas W, Cheney R, Hicks W, Rigual N, Loree T, Spiegel G, Tan D (2005) Tissue eosinophilia: a morphologic marker for assessing stromal invasion in laryngeal squamous neoplasms. BMC Clin Pathol 5(1):1
Fernández-Aceñero MJ, Galindo-Gallego M, Sanz J, Aljama A (2000) Prognostic influence of tumor-associated eosinophilic infiltrate in colorectal carcinoma. Cancer 88(7):1544-1548. PMID: 10738211
Bethwaite PB, Holloway LJ, Yeong ML, Thornton A (1993) Effect of tumour associated tissue eosinophilia on survival of women with stage IB carcinoma of the uterine cervix. J Clin Pathol 46(11):1016-20. https://doi.org/10.1136/jcp.46.11.1016. PMID: 8254087; PMCID: PMC501685
Vaibhav SL, Priya PL, Sonam CK, Supriya K, Garima Y, Sabeer S, Juvale P, Javir G (2018) Evaluation of tumor-associated tissue eosinophilia in different stages of oral squamous cell carcinoma using special stains: an in vitro histopathological study. J Contemp Dent Pract 19(5):579-586. PMID: 29807970
Bankur R, Rodrigues C, Anjaly D, Gopinathan PA, Bankur PK (2016) Quantitative analysis of tumor-associated tissue eosinophilia in different histological grades of oral squamous cell carcinoma. Indian J Dent Res 27:463–467
Ercan I, Cakir B, Başak T, Ozdemir T, Sayin I, Turgut S (2005) Prognostic significance of stromal eosinophilic infiltration in cancer of the larynx. Otolaryngol Head Neck Surg 132(6):869-873. https://doi.org/10.1016/j.otohns.2005.01.041. PMID: 15944557
McGavran MH, Bauer WC, Ogura JH (1961) The incidence of cervical lymph node metastasis from epidermoid carcinoma of the larynx and their relationship to certain characteristics of the primary tumor. A study based on the clinical and pathological findings for 96 patients treated by primary en bloc laryngectomy and radical neck dissection. Cancer. 14:55–66