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Vai trò của cyclase adenylyl hòa tan trong việc cảm nhận và điều chỉnh pH nội bào
Pflügers Archiv - 2024
Tóm tắt
Cyclase adenylyl hòa tan (sAC) khác biệt với cyclase adenylyl xuyên màng (tmAC) ở nhiều khía cạnh. Đặc biệt, hoạt động của sAC không bị điều chỉnh bởi các protein G mà bởi nồng độ bicarbonate hiện hành bên trong tế bào. Do đó, sAC đóng vai trò như một cảm biến pH nội bào tinh vi, với khả năng chuyển đổi các thay đổi pH thành việc điều chỉnh vị trí và/hoặc hoạt động của các protein tế bào liên quan đến cân bằng pH. Trong bài đánh giá này, chúng tôi cung cấp cái nhìn tổng thể về tài liệu mô tả việc điều chỉnh hoạt động của sAC bởi bicarbonate, chỉ ra tầm quan trọng của sự phân đoạn các cascades tín hiệu cAMP nội bào. Ngoài ra, các ví dụ về các quá trình liên quan đến sự vận chuyển proton và bicarbonate trong các loại tế bào khác nhau, trong đó sAC đóng vai trò điều tiết quan trọng, đã được mô tả chi tiết.
Từ khóa
#cyclase adenylyl hòa tan #pH nội bào #bicarbonate #protein G #cAMP #cảm biến pH #phân đoạn tín hiệuTài liệu tham khảo
Akbari A et al (2019) ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria. Hum Reprod 34(6):1155–1164
Ala A et al (2006) Increased prevalence of primary biliary cirrhosis near Superfund toxic waste sites. Hepatology 43(3):525–531
Appukuttan A et al (2012) Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion. Cardiovasc Res 93(2):340–349
Balbach M et al (2023) On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat Commun 14(1):637
Beuers U et al (2010) The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies. Hepatology 52(4):1489–1496
Bizerra PFV et al (2024) Opposite regulation of glycogen metabolism by cAMP produced in the cytosol and at the plasma membrane. Biochim Biophys Acta Mol Cell Res 1871(1):119585
Braun DA et al (2016) Prevalence of monogenic causes in pediatric patients with nephrolithiasis or nephrocalcinosis. Clin J Am Soc Nephrol 11(4):664–672
Buck J et al (1999) Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proc Natl Acad Sci U S A 96(1):79–84
Buffone MG, Wertheimer EV, Visconti PE, Krapf D (2014) Central role of soluble adenylyl cyclase and cAMP in sperm physiology. Biochim Biophys Acta 1842(12 Pt B):2610–20
Chaloupka JA et al (2006) Autoinhibitory regulation of soluble adenylyl cyclase. Mol Reprod Dev 73(3):361–368
Chang JC et al (2016) Soluble adenylyl cyclase regulates bile salt-induced apoptosis in human cholangiocytes. Hepatology 64(2):522–534
Chen Y et al (2000) Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science 289(5479):625–628
Chen X et al (2014) A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice. Am J Respir Cell Mol Biol 51(6):750–760
Chen R, Tang R, Ma X, Gershwin ME (2022) Immunologic responses and the pathophysiology of primary biliary cholangitis. Clin Liver Dis 26(4):583–611
De Rasmo D, Panelli D, Sardanelli AM, Papa S (2008) cAMP-dependent protein kinase regulates the mitochondrial import of the nuclear encoded NDUFS4 subunit of complex I. Cell Signal 20(5):989–97
Demarco IA et al (2003) Involvement of a Na+/HCO-3 cotransporter in mouse sperm capacitation. J Biol Chem 278(9):7001–7009
Espejo MS et al (2020) The functional association between the sodium/bicarbonate cotransporter (NBC) and the soluble adenylyl cyclase (sAC) modulates cardiac contractility. Pflugers Arch 472(1):103–115
Esposito G et al (2004) Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A 101(9):2993–2998
Forgac M (2007) Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Nat Rev Mol Cell Biol 8(11):917–929
Geng W et al (2005) Cloning and characterization of the human soluble adenylyl cyclase. Am J Physiol Cell Physiol 288(6):C1305–C1316
Geng W et al (2009) Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase. J Cell Physiol 220(2):332–340
Ge Y et al (2024) Two novel heterozygous ADCY10 variants identified in Chinese pediatric patients with absorptive hypercalciuria: case report and literature review. J Genet 103
Go S et al (2023) Cholangiocytes express an isoform of soluble adenylyl cyclase that is N-linked glycosylated and secreted in extracellular vesicles. Traffic 24(9):413–430
Halbritter J et al (2015) Fourteen monogenic genes account for 15% of nephrolithiasis/nephrocalcinosis. J Am Soc Nephrol 26(3):543–551
Hallows KR et al (2009) Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem 284(9):5774–5783
Jansen ID et al (2009) Ae2(a, b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria. FASEB J 23(10):3470–3481
Kamenetsky M et al (2006) Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol 362(4):623–639
Kleinboelting S et al (2014) Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. Proc Natl Acad Sci U S A 111(10):3727–3732
Kobayashi M, Buck J, Levin LR (2004) Conservation of functional domain structure in bicarbonate-regulated “soluble” adenylyl cyclases in bacteria and eukaryotes. Dev Genes Evol 214(10):503–509
Lark DS et al (2015) Protein kinase A governs oxidative phosphorylation kinetics and oxidant emitting potential at complex I. Front Physiol 6:332
Laudette M et al (2021) Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity. Cell Death Dis 12(9):824
Levine N, Marsh DJ (1971) Micropuncture studies of the electrochemical aspects of fluid and electrolyte transport in individual seminiferous tubules, the epididymis and the vas deferens in rats. J Physiol 213(3):557–570
Li Y et al (2021) Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects. Hum Reprod 37(1):152–177
Litvin TN, Kamenetsky M, Zarifyan A, Buck J, Levin LR (2003) Kinetic properties of “soluble” adenylyl cyclase. Synergism between calcium and bicarbonate. J Biol Chem 278(18):15922–15926
Liu W et al (2023) Lactate modulates iron metabolism by binding soluble adenylyl cyclase. Cell Metab 35(9):1597-1612 e6
Lv M et al (2022) Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformations. Reprod Biol Endocrinol 20(1):5
Lyaruu DM et al (2008) The anion exchanger Ae2 is required for enamel maturation in mouse teeth. Matrix Biol 27(2):119–127
Lynch MJ, Hill EV, Houslay MD (2006) Intracellular targeting of phosphodiesterase-4 underpins compartmentalized cAMP signaling. Curr Top Dev Biol 75:225–259
Mardones P, Medina JF, Elferink RP (2008) Activation of cyclic AMP signaling in Ae2-deficient mouse fibroblasts. J Biol Chem 283(18):12146–12153
Maren TH (1967) Carbonic anhydrase: chemistry, physiology, and inhibition. Physiol Rev 47(4):595–781
Medina JF et al (2003) Anion exchanger 2 is essential for spermiogenesis in mice. Proc Natl Acad Sci U S A 100(26):15847–15852
Pastor-Soler N et al (2003) Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem 278(49):49523–49529
Paunescu TG et al (2008) Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells. Am J Physiol Renal Physiol 294(1):F130–F138
Prieto J, Banales JM, Medina JF (2021) Primary biliary cholangitis: pathogenic mechanisms. Curr Opin Gastroenterol 37(2):91–98
Pozdniakova S, Ladilov Y (2018) Functional significance of the Adcy10-dependent intracellular cAMP compartments. J Cardiovasc Dev Dis 5(2)
Pucino V, Bombardieri M, Pitzalis C, Mauro C (2017) Lactate at the crossroads of metabolism, inflammation, and autoimmunity. Eur J Immunol 47(1):14–21
Puga Molina LC et al (2018) Molecular basis of human sperm capacitation. Front Cell Dev Biol 6:72
Rahman N et al (2016) Soluble adenylyl cyclase is essential for proper lysosomal acidification. J Gen Physiol 148(4):325–339
Ramos-Espiritu L et al (2016) Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat Chem Biol 12(10):838–844
Recalde S et al (2006) Inefficient chronic activation of parietal cells in Ae2a, b(-/-) mice. Am J Pathol 169(1):165–176
Reed BY et al (2002) Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density. J Clin Endocrinol Metab 87(4):1476–1485
Sanderson MJ, Dirksen ER (1989) Mechanosensitive and beta-adrenergic control of the ciliary beat frequency of mammalian respiratory tract cells in culture. Am Rev Respir Dis 139(2):432–440
Schmid A et al (2006) Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells. J Cell Sci 119(Pt 20):4176–4186
Schmid A et al (2007) Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol 130(1):99–109
Schreiber M et al (1998) Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. J Biol Chem 273(6):3509–3516
Shenroy AR, Visweswariah SS (2004) Class III nucleotide cyclases in bacteria and archaebacteria: lineage-specific expansion of adenylyl cyclases and a dearth of guanylyl cyclases. FEBS Lett 561(1–3):11–21
Strazzabosco M et al (2009) Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Hepatology 50(1):244–252
Tanaka A, Leung PS, Gershwin ME (2018) Environmental basis of primary biliary cholangitis. Exp Biol Med (Maywood) 243(2):184–189
Teitelbaum SL (2000) Bone resorption by osteoclasts. Science 289(5484):1504–1508
Turner TN et al (2019) Sex-based analysis of de novo variants in neurodevelopmental disorders. Am J Hum Genet 105(6):1274–1285
Visser L et al (2011) A comprehensive gene mutation screen in men with asthenozoospermia. Fertil Steril 95:1020–4 e1-9
Wang D et al (2007) A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). Proc Natl Acad Sci U S A 104(22):9325–9330
Wang C et al (2020) Use of whole-exome sequencing to identify a novel ADCY10 mutation in a patient with nephrolithiasis. Am J Transl Res 12(8):4576–4581
Windler F et al (2018) The solute carrier SLC9C1 is a Na(+)/H(+)-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding. Nat Commun 9(1):2809
www.proteinatlas.org. Available from: https://www.proteinatlas.org/search/adcy10
Wyatt TA, Spurzem JR, May K, Sisson JH (1998) Regulation of ciliary beat frequency by both PKA and PKG in bovine airway epithelial cells. Am J Physiol 275(4):L827–L835
Yusupova M et al (2023) Distinct cAMP signaling microdomains differentially regulate melanosomal pH and pigmentation. J Invest Dermatol 143(10):2019-2029 e3
Zippin JH et al (2003) Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J 17(1):82–84