The role of botulinum toxin a in the management of lower urinary tract symptoms
Tóm tắt
Lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH) is the most common disease affecting men older than age 40. Although rarely life threatening, BPH may significantly affect quality of life. The mainstay nonsurgical therapy for BPH includes α-adrenergic blockade and/or 5-α-reductase inhibitors. However, current regimens require the daily administration of medication for an indefinite time. Botulinum toxin type A (BTX-A) is an injectable neurotoxin indicated to treat blepharospasm, strabismus, axillary hyperhydrosis, cervical dystonia, and glabellar lines. When injected intraprostatically, BTX-A may treat BPH-related symptoms. This article reviews evidence of BTX-A safety and efficacy in the treatment of LUTS related to BPH. Results are also presented from our first phase 1, dose-escalating study to evaluate the dose-related toxicity of BTX-A to treat LUTS due to BPH. Ultimately, the LUTS-related improvements seen in our study were consistent with earlier published trials using BTX-A to treat LUTS.
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