The role of Granzyme B in atheromatous diseasesThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum.

Canadian Journal of Physiology and Pharmacology - Tập 85 Số 1 - Trang 89-95 - 2007
Ciara M. Chamberlain1, David J. Granville1
1James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Burrard Building, St. Paul’s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada.

Tóm tắt

The mechanism and role of apoptotic cell death in the pathogenesis of atheromatous diseases is an area of intense research. Atherosclerosis is an inflammatory disease and as such, immune-mediated cell killing plays an important role. Recent studies have suggested that Granzyme B and perforin play an important role in atherogenesis. The current manuscript reviews our current understanding pertaining to the role of Granzyme B in cardiac allograft vasculpathy and atherosclerosis.

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