The role of G-proteins in the dimerisation of human somatostatin receptor types 2 and 5

Moller, 2003, Somatostatin receptors, Biochim Biophys Acta, 1616, 1, 10.1016/S0005-2736(03)00235-9 Weckbecker, 2003, Opportunities in somatostatin research: biological, chemical and therapeutic aspects, Nat Rev Drug Discov, 2, 999, 10.1038/nrd1255 Grant, 2008, Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization, Mol Endocrinol, 22, 2278, 10.1210/me.2007-0334 Baragli, 2007, Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 co-immunoprecipitation and fluorescence resonance energy transfer analysis, Cell Signal, 19, 2304, 10.1016/j.cellsig.2007.07.007 Duran-Prado, 2007, Porcine somatostatin receptor 2 displays typical pharmacological sst2 features but unique dynamics of homodimerization and internalization, Endocrinology, 148, 411, 10.1210/en.2006-0920 Grant, 2004, Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking, J Biol Chem, 279, 36179, 10.1074/jbc.M407310200 Grant, 2004, The role of subtype-specific ligand binding and the C-tail domain in dimer formation of human somatostatin receptors, J Biol Chem, 279, 38636, 10.1074/jbc.M406276200 Patel, 2002, Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells, Proc Natl Acad Sci U S A, 99, 3294, 10.1073/pnas.042705099 Rocheville, 2000, Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity, Science, 288, 154, 10.1126/science.288.5463.154 Rocheville, 2000, Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers, J Biol Chem, 275, 7862, 10.1074/jbc.275.11.7862 Pfeiffer, 2001, Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A), J Biol Chem, 276, 14027, 10.1074/jbc.M006084200 Pfeiffer, 2002, Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization, J Biol Chem, 277, 19762, 10.1074/jbc.M110373200 Sharif, 2007, Coexpression of somatostatin receptor subtype 5 affects internalization and trafficking of somatostatin receptor subtype 2, Endocrinology, 148, 2095, 10.1210/en.2006-1266 Ben-Shlomo, 2005, Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion, J Biol Chem, 280, 24011, 10.1074/jbc.M501998200 Parker, 2008, Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi alpha subunit function in CHO cells, Eur J Pharmacol, 579, 13, 10.1016/j.ejphar.2007.10.002 Parker, 2007, Oligomerization of neuropeptide Y (NPY) Y2 receptors in CHO cells depends on functional pertussis toxin-sensitive G-proteins, Regul Pept, 144, 72, 10.1016/j.regpep.2007.06.004 Law, 2005, Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions, J Biol Chem, 280, 11152, 10.1074/jbc.M500171200 Fan, 2005, A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers, J Biol Chem, 280, 38478, 10.1074/jbc.M505644200 Dupre, 2009, The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes, Annu Rev Pharmacol Toxicol, 49, 31, 10.1146/annurev-pharmtox-061008-103038 Jaquet, 2000, Human somatostatin receptor subtypes in acromegaly: distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes, J Clin Endocrinol Metab, 85, 781, 10.1210/jc.85.2.781 Park, 2004, Somatostatin (SRIF) receptor subtype 2 and 5 gene expression in growth hormone-secreting pituitary adenomas: the relationship with endogenous srif activity and response to octreotide, Endocr J, 51, 227, 10.1507/endocrj.51.227 Rohrer, 1998, Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry, Science, 282, 737, 10.1126/science.282.5389.737 Kaslow, 1987, Structure-activity analysis of the activation of pertussis toxin, Biochemistry, 26, 123, 10.1021/bi00375a018 Gurevich, 2008, How and why do GPCRs dimerize?, Trends Pharmacol Sci, 29, 234, 10.1016/j.tips.2008.02.004 Milligan, 2008, A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization, Br J Pharmacol, 153, S216, 10.1038/sj.bjp.0707490 Dalrymple, 2008, G protein-coupled receptor dimers: functional consequences, disease states and drug targets, Pharmacol Ther, 118, 359, 10.1016/j.pharmthera.2008.03.004 Hebert, 1996, A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation, J Biol Chem, 271, 16384, 10.1074/jbc.271.27.16384 Lemmon, 1994, A dimerization motif for transmembrane alpha-helices, Nat Struct Biol, 1, 157, 10.1038/nsb0394-157 Overton, 2003, Oligomerization, biogenesis, and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G protein-coupled receptor, J Biol Chem, 278, 49369, 10.1074/jbc.M308654200 Brauner-Osborne, 2007, Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors, Curr Drug Targets, 8, 169, 10.2174/138945007779315614 Cvejic, 1997, Dimerization of the delta opioid receptor: implication for a role in receptor internalization, J Biol Chem, 272, 26959, 10.1074/jbc.272.43.26959 Dupre, 2006, Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking, J Biol Chem, 281, 34561, 10.1074/jbc.M605012200 Lefkowitz, 2005, Transduction of receptor signals by beta-arrestins, Science, 308, 512, 10.1126/science.1109237 Tulipano, 2004, Differential beta-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes, J Biol Chem, 279, 21374, 10.1074/jbc.M313522200 Gripentrog, 2003, Experimental evidence for lack of homodimerization of the G protein-coupled human N-formyl peptide receptor, J Immunol, 171, 3187, 10.4049/jimmunol.171.6.3187 Meyer, 2006, FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells, Proc Natl Acad Sci U S A, 103, 2138, 10.1073/pnas.0507686103 Decaillot, 2008, Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4, Proc Natl Acad Sci U S A, 105, 16045, 10.1073/pnas.0804106105