The repeated open application test (ROAT)

Contact Dermatitis - Tập 14 Số 4 - Trang 221-227 - 1986
Matti Hannuksela1, H. Salo1
1Department of Dermatology, University of Oulu, SF-90220 Oulu, Finland

Tóm tắt

Repeated open application tests (ROATs) were performed with common ingredients of vehicles in 86 patients with contact dermatitis. The substances were applied twice daily for 7 days to the flexor aspect of the forearm near the cubital fossa, unless dermatitis appeared earlier. Of the patients with a questionable (?+) patch test result, 44% were positive in ROATs. The corresponding figure was 80% in the patients with B positive (+ or ++) response in the patch lest, when the results of ROAT with propylene glycol were excluded. Only 5 of 14 patients reacting lo 30% or to 10% propylene glycol but not in 15 in water in patch testing, showed a positive result to a cream containing 5% propylene glycol in ROAT. All 5 patients with a positive patch test reaction to 1% propylene glycol reacted to 5% propylene glycol in ROAT.The results suggest that ROATs should be performed more often, especially in patients in whom little known or new allergens are suspected as being the cause of allergic contact dermatitis.

Từ khóa


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Thông tin
Thông tin xuất bản

Contact Dermatitis

Tập 14 Số 4

221-227

Thông tin tác giả