The relationship between lifestyle factors and venous thromboembolism among women: a report from the MISS study

British Journal of Haematology - Tập 144 Số 2 - Trang 234-240 - 2009
Pelle G. Lindqvist1, E. Epstein2, Håkan Olsson3
1Department of Obstetrics and Gynaecology, Clinical Science, Malmö University Hospital, Malmö
2Department of Obstetrics and Gynaecology, Lund University Hospital, Lund University, Lund
3Department of Oncology and Cancer Epidemiology, Lund University Hospital, Lund University, Lund, Sweden

Tóm tắt

SummaryThere has been a great advance in our knowledge of the role that thrombophilic factors play in the risk of venous thromboembolic events (VTE). However, the effect of lifestyle factors on VTE has been inadequately explored in large scale studies of women. This cohort study comprised one thousand native Swedish women for each age year between 25 and 64 inclusive (total = 40 000) drawn from the South Swedish population registry for 1990 (n = 40 000), who were followed for a mean of eleven years. Seventy‐four percent completed a questionnaire at the inception of the study (n = 29 518) and 24 098 women responded to a follow‐up inquiry between the years 2000–2002. The main outcome was the relationship between VTE and physical exercise, smoking habits, and alcohol consumption. Moderate drinkers of alcohol (10–15 g/d) and women engaged in strenuous exercise were at half the risk of VTE compared to those who consumed little or no alcohol or lived a sedentary life. Heavy smoking was associated with a 30% increased risk of VTE. Lifestyle factors have a major impact on the risk of VTE. Women non‐smokers who were physically active and who consumed alcohol in moderation were at a lower risk of VTE.

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Tài liệu tham khảo

10.1111/j.1538-7836.2006.01933.x

10.1016/S0140-6736(00)02225-X

10.1055/s-2007-1024412

10.1016/0021-9150(94)05425-I

10.1093/ije/25.6.1182

10.1016/0021-9150(91)90167-2

10.1016/0002-9343(83)90805-7

10.1001/jama.1997.03540320044033

10.1001/archinte.159.16.1886

10.1001/archinte.159.5.445

10.1161/01.RES.0000046233.94299.D6

10.7326/0003-4819-140-5-200403020-00008

10.1016/j.thromres.2006.12.003

10.1034/j.1600-0412.2003.00118.x

10.1016/S0029-7844(99)00308-7

Lindqvist P.G., 1999, Activated protein C resistance (FV:Q506) and pregnancy, Thrombosis and Haemostasis, 81, 532, 10.1055/s-0037-1614519

10.1182/blood-2004-08-3253

10.1111/j.1471-0528.1996.tb09875.x

10.1161/hc3701.096067

10.1016/j.amepre.2005.01.011

10.1001/jama.1995.03530190040032

10.7326/0003-4819-130-8-199904200-00004

10.1016/S0140-6736(98)10266-0

10.2165/00007256-199622050-00002

10.1161/01.CIR.83.5.1692

10.1161/01.ATV.20.1.271

Zöller B., 1996, High prevalence of the FVR506Q mutation causing APC resistance in a region of southern Sweden with a high incidence of venous thrombosis, Thrombosis Research, 83, 475

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Thông tin xuất bản

British Journal of Haematology

Tập 144 Số 2

234-240

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