The prophenoloxidase‐activating system in invertebrates

Immunological Reviews - Tập 198 Số 1 - Trang 116-126 - 2004
Lage Cerenius1, Kenneth Söderhäll2
1Department of Comparative Physiology, Evolutionary Biology Center, Uppsala University, Uppsala, Sweden
2Authors' address #R##N#Department of Comparative Physiology, Evolutionary Biology Center, Uppsala University, Uppsala, Sweden.

Tóm tắt

Summary:  A major innate defense system in invertebrates is the melanization of pathogens and damaged tissues. This important process is controlled by the enzyme phenoloxidase (PO) that in turn is regulated in a highly elaborate manner for avoiding unnecessary production of highly toxic and reactive compounds. Recent progress, especially in arthropods, in the elucidation of mechanisms controlling the activation of zymogenic proPO into active PO by a cascade of serine proteinases and other factors is reviewed. The proPO‐activating system (proPO system) is triggered by the presence of minute amounts of compounds of microbial origins, such as β‐1,3‐glucans, lipopolysaccharides, and peptidoglycans, which ensures that the system will become active in the presence of potential pathogens. The presence of specific proteinase inhibitors prevents superfluous activation. Concomitant with proPO activation, many other immune reactions will be produced, such as the generation of factors with anti‐microbial, cytotoxic, opsonic, or encapsulation‐promoting activities.

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Tài liệu tham khảo

10.1016/S0952-7915(98)80026-5

Ashida M, 1998, Molecular Mechanisms of Immune Responses in Insects, 135

10.1073/pnas.92.4.939

10.1093/oxfordjournals.jbchem.a124040

10.1016/S0965-1748(00)00068-0

10.1046/j.1432-1327.2001.01945.x

10.1074/jbc.M205508200

10.1074/jbc.M205743200

10.1046/j.1432-1033.2002.03155.x

10.1046/j.1432-1327.2000.01695.x

10.1016/S1046-5928(03)00020-2

10.1016/S0965-1748(02)00191-1

10.1016/S0145-305X(99)00035-X

10.1093/emboj/cdf661

10.1016/S1534-5807(02)00267-8

10.1073/pnas.212301199

10.1074/jbc.M107220200

10.1016/S0145-305X(99)00005-1

10.1016/S0965-1748(97)00045-3

10.1046/j.1365-2583.1998.71047.x

10.1074/jbc.274.17.11727

10.1046/j.1365-2583.1998.71049.x

10.1073/pnas.92.17.7774

10.1073/pnas.92.17.7769

10.1016/S0965-1748(97)00081-7

10.1016/S0965-1748(97)00066-0

10.1073/pnas.92.17.7764

10.1016/S0014-5793(99)00067-8

10.1046/j.1365-2583.2001.00242.x

10.1046/j.1365-2583.2001.00241.x

10.1016/S0965-1748(00)00105-3

10.1046/j.1365-2583.2000.00169.x

10.1016/S0965-1748(02)00030-9

10.1023/A:1023325610300

10.1093/oxfordjournals.molbev.a003792

10.1074/jbc.R100010200

10.1002/(SICI)1097-0177(199703)208:3<363::AID-AJA7>3.0.CO;2-G

10.1007/BF00695771

10.1016/0020-1790(86)90032-6

10.1093/emboj/cdf545

10.1046/j.1462-5822.2003.00282.x

10.1074/jbc.M008426200

10.1074/jbc.M008425200

10.1016/S0145-305X(03)00039-9

10.1016/S0378-1119(02)01187-3

10.1126/science.1077136

10.1023/A:1018730404305

10.1023/A:1010233307490

10.1042/bj20021058

10.1074/jbc.274.11.7441

10.1016/0020-1790(91)90002-V

10.1046/j.1432-1327.1998.2540050.x

10.1046/j.1432-1327.1998.2570615.x

10.1073/pnas.95.21.12220

10.1016/S0965-1748(99)00113-7

10.1016/S0145-305X(02)00099-X

10.4049/jimmunol.166.12.7319

10.1074/jbc.275.14.9996

10.1016/0020-1790(90)90030-X

10.1042/bj2480223

10.1073/pnas.94.13.6682

10.1016/S1096-4959(01)00530-9

10.1074/jbc.272.2.1082

10.1007/s10059-000-0186-2

10.1016/S0965-1748(96)00070-7

10.1073/pnas.92.7.2964

10.1021/bi9819834

10.1006/bbrc.2000.2138

10.1002/arch.10088

10.1074/jbc.273.40.25889

10.1074/jbc.M010436200

10.1016/0014-5793(96)00326-2

10.1021/bi980879j

10.1074/jbc.M002556200

10.1074/jbc.M102596200

10.1111/j.1365-2621.2001.tb16093.x

10.1016/S0003-9861(02)00615-X

10.1016/S0968-0004(00)01602-9

10.1016/S1096-4959(02)00220-8

10.1074/jbc.M209239200

10.1074/jbc.M103817200

10.1016/S0145-305X(99)00013-0

Wang R, A transglutaminase involved in the coagulation system of the freshwater crayfish, Pacifastacus leniusculus. Tissue localisation and cDNA cloning, Fish Shellfish Immunol, 11, 623, 10.1006/fsim.2001.0341

10.1073/pnas.96.5.1965

10.1046/j.1432-1327.1999.00909.x

10.1073/pnas.95.24.14337

10.1016/S0952-7915(02)00005-5

10.1016/0020-1790(88)90045-5

10.1074/jbc.271.23.13854

10.1074/jbc.274.17.11854

Cerenius L, 1994, Structure and biological activity of a 1,3‐β‐D‐glucan‐binding protein in crustacean blood, J Biol Chem, 269, 29462, 10.1016/S0021-9258(18)43902-6

10.1074/jbc.275.2.1337

10.1006/fsim.2002.0420

KurataS.Recognition of infectious non‐self and activation of immune responses by peptidoglycan recognition protein (PGRP)‐family members inDrosophila.Dev Comp Immunol2003.

10.1073/pnas.102176599

10.1073/pnas.152271999

10.1126/science.290.5494.1166

10.1016/S0169-5347(02)00013-7

10.1074/jbc.275.11.7505

10.1046/j.0962-1075.2001.00268.x

10.1073/pnas.96.26.14795

10.1016/0965-1748(95)00040-2