The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5

Experimental and Molecular Medicine - Tập 47 Số 12 - Trang e200-e200
Mi Hee Park1, Kang‐Yell Choi2, Do Sik Min1
1Department of Molecular Biology, College of Natural Science, Pusan National University, Busan, Republic of Korea
2Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea

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Sorkin A, von Zastrow M . Endocytosis and signalling: intertwining molecular networks. Mol Cell Biol 2009; 10: 609–622.

Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH . The roles of phospholipase D in EGFR signaling. Biochim Biophys Acta 2009; 1791: 862–868.

Kang DW, Choi CY, Cho YH, Tian H, Di Paolo G, Choi KY et al. Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells. J Exp Med 2015; 212: 1219–1237.

Hwang WC, Kim MK, Song JH, Choi KY, Min DS . Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells. Exp Mol Med 2014; 46: e124.

Jang YH, Choi KY, Min DS . Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy. Cell Death Differ 2014; 21: 533–546.

Kang DW, Choi K, Min DS . Functional regulation of phospholipase D expression in cancer and inflammation. J Biol Chem 2014; 289: 22575–22582.

Jang JH, Lee CS, Hwang D, Ryu SH . Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners. Prog Lipid Res 2012; 51: 71–81.

Jenkins GM, Frohman MA . Phospholipase D: a lipid centric review. Cell Mol Life Sci 2005; 62: 2305–2316.

Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG et al. The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis. Nat Cell Biol 2006; 8: 477–484.

Stenmark H, Parton RG, Steele-Mortimer O, Lütcke A, Gruenberg J, Zerial M . Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J 1994; 13: 1287.

Harris AL . Hypoxia—a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38–47.

Semenza GL . Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721–732.

Wang Y, Roche O, Yan MS, Finak G, Evans AJ, Metcalf JL et al. Regulation of endocytosis via the oxygen-sensing pathway. Nat Med 2009; 15: 319–324.

Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastase. Cancer Res 1999; 59: 5830–5835.

Park MH, Choi KY, Jung Y, Min DS . Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability. Oncotarget 2014; 5: 11857–11872.

Min DS, Ahn BH, Rhie DJ, Yoon SH, Hahn SJ, Kim MS et al. Expression and regulation of phospholipase D during neuronal differentiation of PC12 cells. Neuropharmacol 2001; 41: 384–391.

Park MH, Ahn BH, Hong YK, Min DS . Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways. Carcinogenesis 2009; 30: 356–365.

Pfeffer SR . Motivating endosome motility. Nat Cell Biol 1999; 1: E145–E147.

Bucci C, Parton RG, Mather IH, Stunnenberg H, Simons K, Hoflack B et al. The small GTPase rab5 functions as regulatory factor in the early endocytic pathway. Cell 1992; 70: 729–740.

Korobko EV, Palgova IV, Kiselev SL, Korobko IV . Apoptotic cleavage of rabaptin-5-like proteins and a model for rabaptin-5 inactivation in apoptosis. Cell Cycle 2006; 5: 1854–1858.

Stenmark H, Vitale G, Ullrich O, Zerial M . Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. Cell 1995; 83: 423–432.

Du G, Huang P, Liang BT, Frohman MA . Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol Biol Cell 2004; 15: 1024–1030.

Shen Y, Xu L, Foster DA . Role for phospholipase D in receptor-mediated endocytosis. Mol Cell Biol 2001; 21: 595–602.

Henley JR, Krueger EW, Oswald BJ, McNiven MA . Dynamin-mediated internalization of caveolae. J Cell Biol 1998; 141: 85–99.

Blume-Jensen P, Hunter T . Oncogenic kinase signalling. Nature 2001; 411: 355–365.

Franovic A, Gunaratnam L, Smith KRI, Patten D, Lee S . Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer. Proc Natl Acad Sci USA 2007; 104: 13092–13097.

Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM . Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003; 3: 347–361.

Koochekpour S, Jeffers M, Wang PH, Gong C, Taylor GA, Roessler LM et al. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Mol Cell Biol 1999; 19: 5902–5912.

Wang Y, Roche O, Xu C, Moriyama EH, Heir P, Chung J et al. Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1. Proc Natl Acad Sci USA 2012; 109: 4892–4897.

Donaldson JG . Phospholipase D in endocytosis and endosomal recycling pathways. Biochim Biophys Acta 2009; 1797: 845–849.

Selvy PE, Lavieri RR, Lindsley CW, Brown HA . Phospholipase d: enzymology, functionality, and chemical modulation. Chem Rev 2011; 111: 6064–6119.

Botelho RJ, Teruel M, Dierckman R, Anderson R, Wells A, York JD et al. Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J Cell Biol 2000; 151: 1353–1368.

Lee JS, Kim IS, Kim JH, Cho W, Suh PG, Ryu SH . Determination of EGFR endocytosis kinetic by auto-regulatory association of PLD1 with mu2. PLoS One 2009; 4: 7090.

Avraham R, Yarden Y . Feedback regulation of EGFR signalingLdecision making by early and delayed loops. Nat Rev Mol Cell Biol 2011; 12: 104–117.