The other side of the orexins: endocrine and metabolic actions

American Journal of Physiology - Endocrinology and Metabolism - Tập 284 Số 1 - Trang E13-E17 - 2003
Meghan M. Taylor1, Willis K. Samson1
1Pharmacological and Physiological Science, St. Louis University School of Medicine, St. Louis, Missouri 63104

Tóm tắt

Although it is clear that the orexin/hypocretin peptides have a significant, physiologically relevant role in sleep/wakefulness, a broader picture has emerged indicating metabolic actions that may depend upon both neural and endocrine mechanisms for their manifestation. The ability of exogenous peptide to activate sympathetic tone, increase locomotor activity, and alter feeding behavior, together with the observed alterations in those functions in knockout animals, strongly suggests important neural actions of the endogenous orexins/hypocretins. Likewise, the action of exogenously administered peptides to alter endocrine function, in particular corticotropin release, has now been mirrored by potential endocrinopathies in knockout animals. Thus these pluripotent peptides hold great potential not only for the treatment of human narcolepsy but also to provide insight into the coordinated regulation of multiple physiological systems.

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Tài liệu tham khảo

10.1210/jcem.86.7.7433

10.1016/S0092-8674(00)81973-X

10.1152/ajpregu.2000.278.3.R692

10.1016/S0169-328X(99)00317-4

10.1073/pnas.96.2.748

10.1073/pnas.95.1.322

10.1016/S0196-9781(00)00311-9

10.1073/pnas.96.19.10911

10.1016/S0896-6273(01)00293-8

10.1093/sleep/9.1.254

10.1523/JNEUROSCI.19-03-01072.1999

10.1046/j.1365-2826.2000.00572.x

10.1016/S0166-2236(00)01594-0

10.1097/00001756-200006260-00034

10.1016/S0092-8674(00)81965-0

10.1159/000048219

10.1006/hbeh.2000.1584

10.1006/bbrc.1998.9750

10.1002/cne.1190

10.1016/S0959-4388(02)00331-8

10.1016/S0006-8993(99)01336-0

10.1385/ENDO:14:2:269

10.1016/S0024-3205(99)00611-6

10.1038/79690

10.1523/JNEUROSCI.18-23-09996.1998

Pu S, 1998, Regul Pept, 78, 133, 10.1016/S0167-0115(98)00128-1

10.1046/j.0953-816x.2001.01518.x

10.1046/j.1365-2826.2000.00582.x

10.1016/S0092-8674(00)80949-6

10.1016/S0006-8993(99)01457-2

10.1016/S1043-2760(00)00273-3

10.1152/ajpregu.2001.281.4.R1140

10.1016/S0167-0115(01)00353-6

10.1016/S0140-6736(05)74704-8

10.1152/ajpregu.1999.277.6.R1780

10.1016/S0014-2999(02)01429-2

10.1016/S0014-5793(99)01030-3

10.1006/bbrc.1999.1573

10.1016/S0896-6273(00)00058-1

10.1016/S0014-5793(98)01266-6

10.1523/JNEUROSCI.18-19-07962.1998

10.1006/bbrc.1999.1998

10.1016/S0006-8993(00)02043-6

10.1177/153537020122600513

10.1093/hmg/9.1.69

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American Journal of Physiology - Endocrinology and Metabolism

Tập 284 Số 1

E13-E17

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