The ontogeny of lactate dehydrogenase in the chick cornea

Wiley - Tập 165 Số 2 - Trang 309-315 - 1967
S. Alcorn1, H. Maisel1
1Department of Anatomy, Wayne State University, School of Medicine, Detroit, Michigan

Tóm tắt

AbstractThe activity of the enzyme lactate dehydrogenase during development of the chick cornea was investigated by starch gel electrophoresis and by spectrophotometric analysis. The isozyme pattern of the cornea prior to the fourteenth day of incubation shows a predominance of LDH 1–3. During subsequent development, there is a marked increase in LDH 4 and 5, so that at hatching, LDH 2–5 stain with nearly equal intensity while LDH 1 shows less activity. From about ten days after hatching, the isozyme pattern is characterized by the presence of LDH 1–5 with isozymes 4 and 5 predominant as in the adult cornea. The period of increase in cathodal isozymes coincides with the time of appearance of corneal transparency, and probably reflects a change in metabolic activity occurring at this time of development.

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Tài liệu tham khảo

10.1016/S0014-4835(61)80016-X

10.1016/S0014-4835(66)80041-6

10.1126/science.136.3520.962

10.1002/jcp.1030510102

Kinoshita J. H., 1962, Some aspects of carbohydrate metabolism of the cornea, Invest. Ophthal., 1, 178

10.1016/S0021-9258(19)52451-6

Maisel H., 1965, The ontogeny of lactate dehydrogenase in the chick lens, Invest. Ophthal., 4, 362

10.1073/pnas.45.5.753

10.1042/bj0610629

10.1016/0304-4165(66)90349-7

10.1126/science.150.3704.1735

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Thông tin xuất bản

Wiley

Tập 165 Số 2

309-315

Thông tin tác giả