The “neuro” of neuroblastoma: <scp>N</scp>euroblastoma as a neurodevelopmental disorder

Annals of Neurology - Tập 80 Số 1 - Trang 13-23 - 2016
Nancy Ratner1, Garrett M. Brodeur2, Russell C. Dale3, Nina F. Schor4
1Department of Pediatrics Cincinnati Children's Hospital and University of Cincinnati Cincinnati OH
2Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
3Clinical School, the Children's Hospital at Westmead University of Sydney Sydney New South Wales Australia
4Department of Pediatrics, University of Rochester Medical Center, Rochester, NY

Tóm tắt

Neuroblastoma is a childhood cancer derived from cells of neural crest origin. The hallmarks of its enigmatic character include its propensity for spontaneous regression under some circumstances and its association with paraneoplastic opsoclonus, myoclonus, and ataxia. The neurodevelopmental underpinnings of its origins may provide important clues for development of novel therapeutic and preventive agents for this frequently fatal malignancy and for the associated paraneoplastic syndromes. Ann Neurol 2016;80:13–23

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