The natural history of cardiac rhabdomyoma with and without tuberous sclerosis

Wiley - Tập 85 Số 8 - Trang 928-931 - 1996
G. Bosi1, Lintermans Jp2, Pellegrino Pa3, G Svaluto‐Moreolo3, André Vliers2
1Pediatric Cardiology Unit, Institute of Pediatrics, University of Ferrara, Italy
2Department of Pediatric Cardiology, University Hospital St. Luc, Catholic University of Louvain, Bruxelles, Belgium
3Pediatric Cardiology Service, Department of Pediatrics, University of Padova, Italy

Tóm tắt

The aim of the present study is to contribute to the knowledge of the natural history of cardiac rhabdomyoma in children with and without tuberous sclerosis. In a retrospective study, 33 children with cardiac rhabdomyoma were collected from three pediatric cardiology centres. In 30/33 patients tuberous sclerosis was associated. High prevalence of cardiac rhabdomyoma was found in infancy, with 21/23 detected before the age of 1 year, and 11/33 before 1 month of age. Cardiac manifestations were present in 19 patients: cardiac rhythm disturbances were detected in 13; in 6/33 a Wolff‐Parkinson‐White syndrome was documented, of which 4 presented paroxysmal arrhythmias. Obstructive or regurgitative phenomena were present in 5; and in 2 patients surgical removal proved necessary. With the exception of one tumoural mass in the right atrium, all 77 tumours were located somewhere in the ventricles, including at atrioventricular valve level. Because of spontaneous regression of most of the tumoural masses, treatment should at first be symptomatic, while surgical removal is required only in life‐threatening conditions, as documented in 2 of our 33 patients.

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Wiley

Tập 85 Số 8

928-931

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