The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism

Nutrition & Metabolism - Tập 9 - Trang 1-7 - 2012
Xian-Cheng Jiang1, Weijun Jin1, Mahmood M Hussain1
1Department of Cell Biology, Downstate Medical Center, State University of New York, Brooklyn, USA

Tóm tắt

It has been reported that phospholipid transfer protein (PLTP) is an independent risk factor for human coronary artery disease. In mouse models, it has been demonstrated that PLTP overexpression induces atherosclerosis, while its deficiency reduces it. PLTP is considered a promising target for pharmacological intervention to treat atherosclerosis. However, we must still answer a number of questions before its pharmaceutical potential can be fully explored. In this review, we summarized the recent progresses made in the PLTP research field and focused on its effect on apoB-containing- triglyceride-rich particle and HDL metabolism.

Tài liệu tham khảo

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