The hypoglycemic effect of Juglans regia leaves aqueous extract in diabetic patients: A first human trial

DARU Journal of Pharmaceutical Sciences - 2014
Saeed Hosseini1, H Fallah Huseini2, Bagher Larijani1, Kazem Mohammad3, Alireza Najmizadeh4, K Nourijelyani3, Leila Jamshidi5
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2Pharmacology and Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
3Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, School of Public Health, Tehran, Iran
4Karaj Diabetes Society, Alborz, Karaj, Iran
5Department of Nutrition, Tehran University of Medical Sciences, School of Public Health, Tehran, Iran

Tóm tắt

Abstract Background

Juglans regia L. (J. regia ) is one of the medicinal plants traditionally used for treatment of diabetes in Iranian medicine. The effect of this plant has already been investigated on animal models; however, this is the first study conducted on human subjects. The aim of this study is to investigate the hypoglycemic effect of J. regia leaves aqueous extract in type 2 diabetes patients. Fifty eight Iranian male and female patients with type 2 diabetes were enrolled. The patients were randomly allocated into two groups. One group (n = 30) received J. regia leaves extract while the other group (n = 28) received placebo. Fasting blood samples were collected at the beginning of the study and after two months for determination of HbA1c and blood glucose level as a main outcome and insulin, SGOT, SGPT, and ALP level as secondary outcome.

 Results

Our analysis showed that serum fasting HbA1C and blood glucose levels were significantly decreased and the insulin level was increased in patients in the J. regia arm.

 Conclusions

The results indicate that J. regia aqueous extract favorably affects blood levels of glucose, insulin and HbA1C in type 2 diabetic patients.

Từ khóa


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