The hypoglycemic effect of Juglans regia leaves aqueous extract in diabetic patients: A first human trial

DARU Journal of Pharmaceutical Sciences - 2014
Saeed Hosseini1, H Fallah Huseini2, Bagher Larijani1, Kazem Mohammad3, Alireza Najmizadeh4, K Nourijelyani3, Leila Jamshidi5
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2Pharmacology and Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
3Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, School of Public Health, Tehran, Iran
4Karaj Diabetes Society, Alborz, Karaj, Iran
5Department of Nutrition, Tehran University of Medical Sciences, School of Public Health, Tehran, Iran

Tóm tắt

Abstract Background Juglans regia L. (J. regia ) is one of the medicinal plants traditionally used for treatment of diabetes in Iranian medicine. The effect of this plant has already been investigated on animal models; however, this is the first study conducted on human subjects. The aim of this study is to investigate the hypoglycemic effect of J. regia leaves aqueous extract in type 2 diabetes patients. Fifty eight Iranian male and female patients with type 2 diabetes were enrolled. The patients were randomly allocated into two groups. One group (n = 30) received J. regia leaves extract while the other group (n = 28) received placebo. Fasting blood samples were collected at the beginning of the study and after two months for determination of HbA1c and blood glucose level as a main outcome and insulin, SGOT, SGPT, and ALP level as secondary outcome. Results Our analysis showed that serum fasting HbA1C and blood glucose levels were significantly decreased and the insulin level was increased in patients in the J. regia arm. Conclusions The results indicate that J. regia aqueous extract favorably affects blood levels of glucose, insulin and HbA1C in type 2 diabetic patients.

Từ khóa


Tài liệu tham khảo

Shaw JE, Sicree RA, Zimmet PZ: Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010, 87 (1): 4-14. 10.1016/j.diabres.2009.10.007. PubMed,MedLine, PDF

Shojaii A, Dabaghian FH, Goushegir A, Fard MA: Antidiabetic plants of Iran. Acta Med Iran. 2011, 49 (10): 637-642. PubMed,MedLine, PDF

Suksomboon N, Poolsup N, Boonkaew S, Suthisisang CC: Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes. J Ethnopharmacol. 2011, 137 (3): 1328-1333. 10.1016/j.jep.2011.07.059.

Rahman MA, Mossa JS, Al-Said MS, Al-Yahya MA: Medicinal plant diversity in the flora of Saudi Arabia 1: a report on seven plant families. Fitoterapia. 2004, 75 (2): 149-161. 10.1016/j.fitote.2003.12.012.

Mozafarian V: Walnut tree. Identification of medicinal and aromatic plants of Iran. 2012, Tehran, Iran: Farhang Moaser press, 473-475.

Kaumar S, Harkonen PL, Arora S, Kaur M: Studies on correlation of antimutagenic and antiproliferative activities of Juglans regia L. J Environ Pathol Toxicol Oncol. 2003, 22: 59-67. PDF

Amaral JS, Seabra RM, Andrade PB, Valent AOP, Pereira JA, Ferreres F: Phenolic profile in the quality control of walnut (Juglans regia L.) leaves. J Food Chem. 2004, 88: 373-379. 10.1016/j.foodchem.2004.01.055.

Pereira JA, Oliveira I, Sousa A, Valenta˜ob P, Andrade PB, Ferreira I: Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. J Food Chem Tox. 2007, 45: 2287-2295. 10.1016/j.fct.2007.06.004. Pubmed, Medline,Fulltext

Mohammadi J, Sadeqpour K, Delaviz H, Mohammadi B: Anti-diabetic effects of an alcoholic extract of Juglans regia in an animal model. Turk J Med Sci. 2011, 41: 685-691. Pubmed, Medline,PDF

Jelodar G, Mohsen M, Shahram S: Effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats. Afr J Trad CAM. 2007, 43: 299-305. Pubmed, Medline,PDF

Asgary S, Parkhideh S, Solhpour A, Madani H, Mahzouni P, Rahimi P: Effect of ethanolic extract of Juglans regia L. on blood sugar in diabetes-induced rats. J Med Food. 2008, 11: 533-538. 10.1089/jmf.2007.0611. Pubmed, Medline,PDF

American Diabetes Association: Screening for type 2 diabetes. Diabetes Care. 2003, 26: 21-24. Pubmed, Medline,PDF

Ortiz-Andrade RR, Garcia-Jimenez S, Castillo-Espana P, Ramirez-A G, Villalobos-Molina R, Estrada-Soto S: α-Glucosidase inhibitory activity of the methanolic extract from Tournefortia hartwegiana: an antihyperglycemic agent. J Ethnopharmacol. 2007, 109: 48-53. 10.1016/j.jep.2006.07.002. CrossRef, PubMed, CAS, Web of Science® Times Cited: 28

Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A: Dietary (Poly) phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal. 2013, 18 (14): 1818-1892. 10.1089/ars.2012.4581.

Pereira JA, Oliveira I, Sousa A, Ferreira I, Bento A, Estevinho L: Bioactive properties and chemical composition of six walnut (Juglans regia L.) cultivars. Food ChemToxicol. 2008, 46: 2103-2111. 10.1016/j.fct.2008.02.002. CrossRef, Web of Science®

Savage GP: Chemical composition of walnuts (Juglans regia L.) grown in New Zealand. Plant Food Hum Nutr. 2001, 56: 75-82. 10.1023/A:1008175606698. Pubmed, Medline,PDF

Fukuda T, Ito H, Yoshida T: Antioxidative polyphenols from walnuts (Juglans regia L.). Phytochemistry. 2004, 63: 795-801. Pubmed, PDF

Banerji MA, Buckley MC, Chaiken RL, Gordon D, Lebovitz HE, Kral JG: Liver fat, serum triglycerides and visceral adipose tissue in insulin sensitive and insulin-resistant black men with NIDDM. Int J Obes Relat Metab Disord. 1995, 19: 846-850. PubMed, MedLine

Madani H, Rahimi P, Mahzoni P: Effects of hydroalcoholic extract of Juglans regia leaves on activity of AST and ALT enzymes in alloxan- induced diabetic rats. Pharmaceut Sci. 2009, 15 (2): 213-218. PubMed,MedLine, PDF

Thông tin
Thông tin xuất bản

DARU Journal of Pharmaceutical Sciences

Thông tin tác giả