The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2

citation_journal_title=Science; citation_title=Scaffold proteins: hubs for controlling the flow of cellular information; citation_author=MC Good, JG Zalatan, WA Lim; citation_volume=332; citation_publication_date=2011; citation_pages=680-6; citation_doi=10.1126/science.1198701; citation_id=CR1 citation_journal_title=Nat Rev Mol Cell Biol; citation_title=Signalling scaffolds and local organization of cellular behaviour; citation_author=LK Langeberg, JD Scott; citation_volume=16; citation_publication_date=2015; citation_pages=232-44; citation_doi=10.1038/nrm3966; citation_id=CR2 citation_journal_title=J Cell Sci; citation_title=KSR: a MAPK scaffold of the Ras pathway?; citation_author=DK Morrison; citation_volume=114; citation_publication_date=2001; citation_pages=1609-12; citation_id=CR3 citation_journal_title=Mol Cell Biol; citation_title=The JIP group of mitogen-activated protein kinase scaffold proteins; citation_author=J Yasuda, AJ Whitmarsh, J Cavanagh, M Sharma, RJ Davis; citation_volume=19; citation_publication_date=1999; citation_pages=7245-54; citation_doi=10.1128/MCB.19.10.7245; citation_id=CR4 citation_journal_title=Mol Cell Biol; citation_title=IQGAP1 is a scaffold for mitogen-activated protein kinase signaling; citation_author=M Roy, Z Li, DB Sacks; citation_volume=25; citation_publication_date=2005; citation_pages=7940-52; citation_doi=10.1128/MCB.25.18.7940-7952.2005; citation_id=CR5 citation_journal_title=Science; citation_title=Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3; citation_author=PH McDonald, CW Chow, WE Miller, SA Laporte, ME Field, FT Lin; citation_volume=290; citation_publication_date=2000; citation_pages=1574-7; citation_doi=10.1126/science.290.5496.1574; citation_id=CR6 citation_journal_title=Sci Signal; citation_title=Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove; citation_author=A Garai, A Zeke, G Gogl, I Toro, F Fordos, H Blankenburg; citation_volume=5; citation_publication_date=2012; citation_pages=ra74; citation_doi=10.1126/scisignal.2003004; citation_id=CR7 citation_journal_title=Pharmacol Res; citation_title=ERK1/2 MAP kinases: structure, function, and regulation; citation_author=R Roskoski; citation_volume=66; citation_publication_date=2012; citation_pages=105-43; citation_doi=10.1016/j.phrs.2012.04.005; citation_id=CR8 citation_journal_title=PLoS Comput Biol; citation_title=Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors; citation_author=TC Whisenant, DT Ho, RW Benz, JS Rogers, RM Kaake, EA Gordon; citation_volume=6; citation_publication_date=2010; citation_pages=e1000908; citation_doi=10.1371/journal.pcbi.1000908; citation_id=CR9 citation_journal_title=Nat Cell Biol; citation_title=A conserved docking motif in MAP kinases common to substrates, activators and regulators; citation_author=T Tanoue, M Adachi, T Moriguchi, E Nishida; citation_volume=2; citation_publication_date=2000; citation_pages=110-6; citation_doi=10.1038/35000065; citation_id=CR10 citation_journal_title=Mol Cell; citation_title=Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry; citation_author=T Lee, AN Hoofnagle, Y Kabuyama, J Stroud, X Min, EJ Goldsmith; citation_volume=14; citation_publication_date=2004; citation_pages=43-55; citation_doi=10.1016/S1097-2765(04)00161-3; citation_id=CR11 citation_journal_title=Genes Dev; citation_title=Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase; citation_author=D Jacobs, D Glossip, H Xing, AJ Muslin, K Kornfeld; citation_volume=13; citation_publication_date=1999; citation_pages=163-75; citation_doi=10.1101/gad.13.2.163; citation_id=CR12 citation_journal_title=J Biol Chem; citation_title=Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs; citation_author=DL Sheridan, Y Kong, SA Parker, KN Dalby, BE Turk; citation_volume=283; citation_publication_date=2008; citation_pages=19511-20; citation_doi=10.1074/jbc.M801074200; citation_id=CR13 citation_journal_title=Genetics; citation_title=Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase; citation_author=D Jacobs, GJ Beitel, SG Clark, HR Horvitz, K Kornfeld; citation_volume=149; citation_publication_date=1998; citation_pages=1809-22; citation_id=CR14 citation_journal_title=Nat Cell Biol; citation_title=Molecular interpretation of ERK signal duration by immediate early gene products; citation_author=LO Murphy, S Smith, RH Chen, DC Fingar, J Blenis; citation_volume=4; citation_publication_date=2002; citation_pages=556-64; citation_id=CR15 citation_journal_title=Nat Struct Mol Biol; citation_title=Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport; citation_author=H Kosako, N Yamaguchi, C Aranami, M Ushiyama, S Kose, N Imamoto; citation_volume=16; citation_publication_date=2009; citation_pages=1026-35; citation_doi=10.1038/nsmb.1656; citation_id=CR16 citation_journal_title=J Biol Chem; citation_title=Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells; citation_author=Y Matsubayashi, M Fukuda, E Nishida; citation_volume=276; citation_publication_date=2001; citation_pages=41755-60; citation_doi=10.1074/jbc.M106012200; citation_id=CR17 citation_journal_title=Nat Commun; citation_title=Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK; citation_author=PD Mace, Y Wallez, MF Egger, MK Dobaczewska, H Robinson, EB Pasquale; citation_volume=4; citation_publication_date=2013; citation_pages=1681; citation_doi=10.1038/ncomms2687; citation_id=CR18 citation_journal_title=Pflugers Arch; citation_title=The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death; citation_author=SF Pedersen; citation_volume=452; citation_publication_date=2006; citation_pages=249-59; citation_doi=10.1007/s00424-006-0044-y; citation_id=CR19 citation_journal_title=Curr Pharm Des; citation_title=Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy; citation_author=E Boedtkjer, L Bunch, SF Pedersen; citation_volume=18; citation_publication_date=2012; citation_pages=1345-71; citation_doi=10.2174/138161212799504830; citation_id=CR20 citation_journal_title=J Biol Chem; citation_title=Multiple receptors coupled to adenylate cyclase regulate Na-H exchange independent of cAMP; citation_author=MB Ganz, JA Pachter, DL Barber; citation_volume=265; citation_publication_date=1990; citation_pages=8989-92; citation_id=CR21 citation_journal_title=Cancer Lett; citation_title=The Na+/H+ exchanger NHE1, but not the Na+, HCO3-cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2; citation_author=G Lauritzen, CM Stock, J Lemaire, SF Lund, MF Jensen, B Damsgaard; citation_volume=317; citation_publication_date=2012; citation_pages=172-83; citation_doi=10.1016/j.canlet.2011.11.023; citation_id=CR22 citation_journal_title=J Biol Chem; citation_title=Growth factor activation and “H+-sensing” of the Na+/H+ exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation; citation_author=S Wakabayashi, B Bertrand, M Shigekawa, P Fafournoux, J Pouyssegur; citation_volume=269; citation_publication_date=1994; citation_pages=5583-8; citation_id=CR23 citation_journal_title=J Biol Chem; citation_title=Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway; citation_author=RS Haworth, C McCann, AK Snabaitis, NA Roberts, M Avkiran; citation_volume=278; citation_publication_date=2003; citation_pages=31676-84; citation_doi=10.1074/jbc.M304400200; citation_id=CR24 citation_journal_title=J Biol Chem; citation_title=Mitogen-activated protein kinase-dependent activation of the Na+/H+ exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771; citation_author=ME Malo, L Li, L Fliegel; citation_volume=282; citation_publication_date=2007; citation_pages=6292-9; citation_doi=10.1074/jbc.M611073200; citation_id=CR25 citation_journal_title=Cell Physiol Biochem; citation_title=The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells; citation_author=SF Pedersen, BV Darborg, M Rasmussen, J Nylandsted, EK Hoffmann; citation_volume=20; citation_publication_date=2007; citation_pages=735-50; citation_doi=10.1159/000110434; citation_id=CR26 citation_journal_title=J Biol Chem; citation_title=p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1; citation_author=E Takahashi, J Abe, B Gallis, R Aebersold, DJ Spring, EG Krebs; citation_volume=274; citation_publication_date=1999; citation_pages=20206-14; citation_doi=10.1074/jbc.274.29.20206; citation_id=CR27 citation_journal_title=Arch Biochem Biophys; citation_title=Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1; citation_author=SF Pedersen, BV Darborg, ML Rentsch, M Rasmussen; citation_volume=462; citation_publication_date=2007; citation_pages=195-201; citation_doi=10.1016/j.abb.2006.12.001; citation_id=CR28 citation_journal_title=Anal Chem; citation_title=Open tubular immobilized metal ion affinity chromatography combined with MALDI MS and MS/MS for identification of protein phosphorylation sites; citation_author=H Liu, J Stupak, J Zheng, BO Keller, BJ Brix, L Fliegel; citation_volume=76; citation_publication_date=2004; citation_pages=4223-32; citation_doi=10.1021/ac035231d; citation_id=CR29 citation_journal_title=J Pharmacol Exp Ther; citation_title=Antihypertrophic effect of Na+/H+ exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen species; citation_author=S Javadov, D Baetz, V Rajapurohitam, A Zeidan, LA Kirshenbaum, M Karmazyn; citation_volume=317; citation_publication_date=2006; citation_pages=1036-43; citation_doi=10.1124/jpet.105.100107; citation_id=CR30 citation_journal_title=J Biol Chem; citation_title=ERK is regulated by sodium-proton exchanger in rat aortic vascular smooth muscle cells; citation_author=YV Mukhin, MN Garnovskaya, ME Ullian, JR Raymond; citation_volume=279; citation_publication_date=2004; citation_pages=1845-52; citation_doi=10.1074/jbc.M304907200; citation_id=CR31 citation_journal_title=Pflugers Arch; citation_title=Roles of Na+/H+ exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts; citation_author=ML Rentsch, CG Ossum, EK Hoffmann, SF Pedersen; citation_volume=454; citation_publication_date=2007; citation_pages=649-62; citation_doi=10.1007/s00424-007-0233-3; citation_id=CR32 citation_journal_title=Nat Methods; citation_title=A human MAP kinase interactome; citation_author=S Bandyopadhyay, CY Chiang, J Srivastava, M Gersten, S White, R Bell; citation_volume=7; citation_publication_date=2010; citation_pages=801-5; citation_doi=10.1038/nmeth.1506; citation_id=CR33 citation_journal_title=J Biol Chem; citation_title=B-Raf associates with and activates the NHE1 isoform of the Na+/H+ exchanger; citation_author=P Karki, X Li, D Schrama, L Fliegel; citation_volume=286; citation_publication_date=2011; citation_pages=13096-105; citation_doi=10.1074/jbc.M110.165134; citation_id=CR34 citation_journal_title=Biochemistry; citation_title=The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 trafficking; citation_author=AB Norholm, R Hendus-Altenburger, G Bjerre, M Kjaergaard, SF Pedersen, BB Kragelund; citation_volume=50; citation_publication_date=2011; citation_pages=3469-80; citation_doi=10.1021/bi1019989; citation_id=CR35 citation_journal_title=Curr Top Membr; citation_title=Structural dynamics and regulation of the mammalian SLC9A family of Na+/H+ exchangers; citation_author=R Hendus-Altenburger, BB Kragelund, SF Pedersen; citation_volume=73; citation_publication_date=2014; citation_pages=69-148; citation_doi=10.1016/B978-0-12-800223-0.00002-5; citation_id=CR36 citation_journal_title=J Mol Biol; citation_title=Prediction and functional analysis of native disorder in proteins from the three kingdoms of life; citation_author=JJ Ward, JS Sodhi, LJ McGuffin, BF Buxton, DT Jones; citation_volume=337; citation_publication_date=2004; citation_pages=635-45; citation_doi=10.1016/j.jmb.2004.02.002; citation_id=CR37 citation_journal_title=J Mol Biol; citation_title=Intrinsic disorder in cell-signaling and cancer-associated proteins; citation_author=LM Iakoucheva, CJ Brown, JD Lawson, Z Obradovic, AK Dunker; citation_volume=323; citation_publication_date=2002; citation_pages=573-84; citation_doi=10.1016/S0022-2836(02)00969-5; citation_id=CR38 citation_journal_title=Prog Biophys Mol Biol; citation_title=Intrinsic disorder in scaffold proteins: getting more from less; citation_author=MS Cortese, VN Uversky, DA Keith; citation_volume=98; citation_publication_date=2008; citation_pages=85-106; citation_doi=10.1016/j.pbiomolbio.2008.05.007; citation_id=CR39 citation_journal_title=Proc Natl Acad Sci U S A; citation_title=Structure and dynamics of the MKK7-JNK signaling complex; citation_author=J Kragelj, A Palencia, MH Nanao, D Maurin, G Bouvignies, M Blackledge; citation_volume=112; citation_publication_date=2015; citation_pages=3409-14; citation_doi=10.1073/pnas.1419528112; citation_id=CR40 citation_journal_title=Am J Physiol; citation_title=Impaired cell volume regulation in Na(+)-H+ exchange-deficient mutants; citation_author=D Rotin, S Grinstein; citation_volume=257; citation_publication_date=1989; citation_pages=C1158-65; citation_id=CR41 citation_journal_title=J Biol; citation_title=Distinct functions for ERKs?; citation_author=AC Lloyd; citation_volume=5; citation_publication_date=2006; citation_pages=13; citation_doi=10.1186/jbiol46; citation_id=CR42 citation_journal_title=J Biol Chem; citation_title=Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro; citation_author=DJ Robbins, E Zhen, H Owaki, CA Vanderbilt, D Ebert, TD Geppert; citation_volume=268; citation_publication_date=1993; citation_pages=5097-106; citation_id=CR43 citation_journal_title=J Biol Chem; citation_title=The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop; citation_author=B Zhou, ZY Zhang; citation_volume=277; citation_publication_date=2002; citation_pages=13889-99; citation_doi=10.1074/jbc.M200377200; citation_id=CR44 citation_journal_title=EMBO J; citation_title=Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1; citation_author=SH Yang, AJ Whitmarsh, RJ Davis, AD Sharrocks; citation_volume=17; citation_publication_date=1998; citation_pages=1740-9; citation_doi=10.1093/emboj/17.6.1740; citation_id=CR45 citation_journal_title=Anal Chem; citation_title=Bayesian deconvolution of mass and ion mobility spectra: from binary interactions to polydisperse ensembles; citation_author=MT Marty, AJ Baldwin, EG Marklund, GK Hochberg, JL Benesch, CV Robinson; citation_volume=87; citation_publication_date=2015; citation_pages=4370-6; citation_doi=10.1021/acs.analchem.5b00140; citation_id=CR46 citation_journal_title=Biochemistry; citation_title=Activated ERK2 is a monomer in vitro with or without divalent cations and when complexed to the cytoplasmic scaffold PEA-15; citation_author=TS Kaoud, AK Devkota, R Harris, MS Rana, O Abramczyk, M Warthaka; citation_volume=50; citation_publication_date=2011; citation_pages=4568-78; citation_doi=10.1021/bi200202y; citation_id=CR47 citation_journal_title=Nat Commun; citation_title=Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues; citation_author=A Lundby, A Secher, K Lage, NB Nordsborg, A Dmytriyev, C Lundby; citation_volume=3; citation_publication_date=2012; citation_pages=876; citation_doi=10.1038/ncomms1871; citation_id=CR48 citation_journal_title=J Biomol NMR; citation_title=Cell signaling, post-translational protein modifications and NMR spectroscopy; citation_author=FX Theillet, C Smet-Nocca, S Liokatis, R Thongwichian, J Kosten, MK Yoon; citation_volume=54; citation_publication_date=2012; citation_pages=217-36; citation_doi=10.1007/s10858-012-9674-x; citation_id=CR49 citation_journal_title=J Biomol NMR; citation_title=Unraveling a phosphorylation event in a folded protein by NMR spectroscopy: phosphorylation of the Pin1 WW domain by PKA; citation_author=C Smet-Nocca, H Launay, JM Wieruszeski, G Lippens, I Landrieu; citation_volume=55; citation_publication_date=2013; citation_pages=323-37; citation_doi=10.1007/s10858-013-9716-z; citation_id=CR50 citation_journal_title=J Cell Sci; citation_title=Regulation of the formation of tumor cell pseudopodia by the Na+/H+ exchanger NHE1; citation_author=A Lagana, J Vadnais, PU Le, TN Nguyen, R Laprade, IR Nabi; citation_volume=113; citation_issue=Pt 20; citation_publication_date=2000; citation_pages=3649-62; citation_id=CR51 citation_journal_title=J Cell Biol; citation_title=The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium; citation_author=L Schneider, CM Stock, P Dieterich, BH Jensen, LB Pedersen, P Satir; citation_volume=185; citation_publication_date=2009; citation_pages=163-76; citation_doi=10.1083/jcb.200806019; citation_id=CR52 citation_journal_title=Am J Physiol Cell Physiol; citation_title=Intracellular pH gradients in migrating cells; citation_author=C Martin, SF Pedersen, A Schwab, C Stock; citation_volume=300; citation_publication_date=2011; citation_pages=C490-5; citation_doi=10.1152/ajpcell.00280.2010; citation_id=CR53 Pedraz-Cuesta E, Fredsted J, Jensen HH, Bornebusch A, Nejsum LN, Kragelund BB, et al. Prolactin signaling stimulates invasion via the Na+/H+ exchanger NHE1 in T47D human breast cancer cells. Mol Endocrinol. 2015; in revision citation_journal_title=Cell; citation_title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks; citation_author=JV Olsen, B Blagoev, F Gnad, B Macek, C Kumar, P Mortensen; citation_volume=127; citation_publication_date=2006; citation_pages=635-48; citation_doi=10.1016/j.cell.2006.09.026; citation_id=CR55 citation_journal_title=Chem Soc Rev; citation_title=Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes; citation_author=VN Uversky; citation_volume=40; citation_publication_date=2011; citation_pages=1623-34; citation_doi=10.1039/C0CS00057D; citation_id=CR56 citation_journal_title=Science; citation_title=The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway; citation_author=RP Bhattacharyya, A Remenyi, MC Good, CJ Bashor, AM Falick, WA Lim; citation_volume=311; citation_publication_date=2006; citation_pages=822-6; citation_doi=10.1126/science.1120941; citation_id=CR57 citation_journal_title=Nat Chem Biol; citation_title=Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21; citation_author=Y Wang, JC Fisher, R Mathew, L Ou, S Otieno, J Sublet; citation_volume=7; citation_publication_date=2011; citation_pages=214-21; citation_doi=10.1038/nchembio.536; citation_id=CR58 citation_journal_title=Structure; citation_title=Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase; citation_author=T Mittag, J Marsh, A Grishaev, S Orlicky, H Lin, F Sicheri; citation_volume=18; citation_publication_date=2010; citation_pages=494-506; citation_doi=10.1016/j.str.2010.01.020; citation_id=CR59 citation_journal_title=Proc Natl Acad Sci U S A; citation_title=Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase; citation_author=X Tang, S Orlicky, T Mittag, V Csizmok, T Pawson, JD Forman-Kay; citation_volume=109; citation_publication_date=2012; citation_pages=3287-92; citation_doi=10.1073/pnas.1116455109; citation_id=CR60 citation_journal_title=Philos Trans R Soc Lond B Biol Sci; citation_title=Self-assembly of biological macromolecules; citation_author=RN Perham; citation_volume=272; citation_publication_date=1975; citation_pages=123-36; citation_doi=10.1098/rstb.1975.0075; citation_id=CR61 citation_journal_title=Biochem J; citation_title=Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity; citation_author=AJ Bardwell, M Abdollahi, L Bardwell; citation_volume=370; citation_publication_date=2003; citation_pages=1077-85; citation_doi=10.1042/bj20021806; citation_id=CR62 citation_journal_title=Biochemistry; citation_title=Dimerization is crucial for the function of the Na+/H+ exchanger NHE1; citation_author=T Hisamitsu, YB Ammar, TY Nakamura, S Wakabayashi; citation_volume=45; citation_publication_date=2006; citation_pages=13346-55; citation_doi=10.1021/bi0608616; citation_id=CR63 citation_journal_title=PLoS One; citation_title=Interface analysis of the complex between ERK2 and PTP-SL; citation_author=MC Balasu, LN Spiridon, S Miron, CT Craescu, AJ Scheidig, AJ Petrescu; citation_volume=4; citation_publication_date=2009; citation_pages=e5432; citation_doi=10.1371/journal.pone.0005432; citation_id=CR64 citation_journal_title=Proc Natl Acad Sci U S A; citation_title=A quantitative atlas of mitotic phosphorylation; citation_author=N Dephoure, C Zhou, J Villen, SA Beausoleil, CE Bakalarski, SJ Elledge; citation_volume=105; citation_publication_date=2008; citation_pages=10762-7; citation_doi=10.1073/pnas.0805139105; citation_id=CR65 citation_journal_title=Mol Cell Biol; citation_title=Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization; citation_author=AR Khaled, AN Moor, A Li, K Kim, DK Ferris, K Muegge; citation_volume=21; citation_publication_date=2001; citation_pages=7545-57; citation_doi=10.1128/MCB.21.22.7545-7557.2001; citation_id=CR66 citation_journal_title=Am J Physiol Cell Physiol; citation_title=Apoptosis-induced alkalinization by the Na+/H+ exchanger isoform 1 is mediated through phosphorylation of amino acids Ser726 and Ser729; citation_author=AL Grenier, K Abu-Ihweij, G Zhang, SM Ruppert, R Boohaker, ER Slepkov; citation_volume=295; citation_publication_date=2008; citation_pages=C883-96; citation_doi=10.1152/ajpcell.00574.2007; citation_id=CR67 citation_journal_title=Am J Physiol Renal Physiol; citation_title=Acidosis-mediated regulation of the NHE1 isoform of the Na+/H+ exchanger in renal cells; citation_author=A Odunewu, L Fliegel; citation_volume=305; citation_publication_date=2013; citation_pages=F370-81; citation_doi=10.1152/ajprenal.00598.2012; citation_id=CR68 citation_journal_title=PLoS One; citation_title=Phosphorylation and activation of the plasma membrane Na+/H+ exchanger (NHE1) during osmotic cell shrinkage; citation_author=RR Rigor, C Damoc, BS Phinney, PM Cala; citation_volume=6; citation_publication_date=2011; citation_pages=e29210; citation_doi=10.1371/journal.pone.0029210; citation_id=CR69 citation_journal_title=Nat Struct Mol Biol; citation_title=In situ observation of protein phosphorylation by high-resolution NMR spectroscopy; citation_author=P Selenko, DP Frueh, SJ Elsaesser, W Haas, SP Gygi, G Wagner; citation_volume=15; citation_publication_date=2008; citation_pages=321-9; citation_doi=10.1038/nsmb.1395; citation_id=CR70 citation_journal_title=Protein Sci; citation_title=Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II?; citation_author=M Kjaergaard, AB Norholm, R Hendus-Altenburger, SF Pedersen, FM Poulsen, BB Kragelund; citation_volume=19; citation_publication_date=2010; citation_pages=1555-64; citation_doi=10.1002/pro.435; citation_id=CR71 citation_journal_title=Nucleic Acids Res; citation_title=Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs; citation_author=JC Obenauer, LC Cantley, MB Yaffe; citation_volume=31; citation_publication_date=2003; citation_pages=3635-41; citation_doi=10.1093/nar/gkg584; citation_id=CR72 citation_journal_title=Mol Syst Biol; citation_title=Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega; citation_author=F Sievers, A Wilm, D Dineen, TJ Gibson, K Karplus, W Li; citation_volume=7; citation_publication_date=2011; citation_pages=539; citation_doi=10.1038/msb.2011.75; citation_id=CR73 citation_journal_title=Biochim Biophys Acta; citation_title=PONDR-FIT: a meta-predictor of intrinsically disordered amino acids; citation_author=B Xue, RL Dunbrack, RW Williams, AK Dunker, VN Uversky; citation_volume=1804; citation_publication_date=2010; citation_pages=996-1010; citation_doi=10.1016/j.bbapap.2010.01.011; citation_id=CR74 citation_journal_title=Bioinformatics; citation_title=The DISOPRED server for the prediction of protein disorder; citation_author=JJ Ward, LJ McGuffin, K Bryson, BF Buxton, DT Jones; citation_volume=20; citation_publication_date=2004; citation_pages=2138-9; citation_doi=10.1093/bioinformatics/bth195; citation_id=CR75 citation_journal_title=J Biomol NMR; citation_title=NMRPipe: a multidimensional spectral processing system based on UNIX pipes; citation_author=F Delaglio, S Grzesiek, GW Vuister, G Zhu, J Pfeifer, A Bax; citation_volume=6; citation_publication_date=1995; citation_pages=277-93; citation_doi=10.1007/BF00197809; citation_id=CR76 citation_journal_title=Proteins; citation_title=The CCPN data model for NMR spectroscopy: development of a software pipeline; citation_author=WF Vranken, W Boucher, TJ Stevens, RH Fogh, A Pajon, M Llinas; citation_volume=59; citation_publication_date=2005; citation_pages=687-96; citation_doi=10.1002/prot.20449; citation_id=CR77 citation_journal_title=Anal Chem; citation_title=A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies; citation_author=F Sobott, H Hernandez, MG McCammon, MA Tito, CV Robinson; citation_volume=74; citation_publication_date=2002; citation_pages=1402-7; citation_doi=10.1021/ac0110552; citation_id=CR78 citation_journal_title=Nat Protoc; citation_title=Determining the stoichiometry and interactions of macromolecular assemblies from mass spectrometry; citation_author=H Hernandez, CV Robinson; citation_volume=2; citation_publication_date=2007; citation_pages=715-26; citation_doi=10.1038/nprot.2007.73; citation_id=CR79 citation_journal_title=Acta Crystallogr D Biol Crystallogr; citation_title=Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase; citation_author=G Gogl, I Toro, A Remenyi; citation_volume=69; citation_publication_date=2013; citation_pages=486-9; citation_doi=10.1107/S0907444912051062; citation_id=CR80 citation_journal_title=Methods Enzymol; citation_title=Modeller: generation and refinement of homology-based protein structure models; citation_author=A Fiser, A Sali; citation_volume=374; citation_publication_date=2003; citation_pages=461-91; citation_doi=10.1016/S0076-6879(03)74020-8; citation_id=CR81 citation_journal_title=J Biol Chem; citation_title=NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity; citation_author=SF Pedersen, SA King, EB Nygaard, RR Rigor, PM Cala; citation_volume=282; citation_publication_date=2007; citation_pages=19716-27; citation_doi=10.1074/jbc.M701637200; citation_id=CR82