The heparan sulphate deficient Hspg2 exon 3 null mouse displays reduced deposition of TGF-β1 in skin compared to C57BL/6 wild type mice

Journal of Molecular Histology - Tập 47 Số 3 - Trang 365-374 - 2016
Cindy Shu1, Susan Smith1, James Melrose1,2,3
1Raymond Purves Bone and Joint Research Laboratory, Institute of Bone and Joint Research, Kolling Institute Northern Sydney Local Health District, The Royal North Shore Hospital, St. Leonards, Australia
2School of Biomedical Engineering, University of New South Wales, Kensington, Australia
3Sydney Medical School, Northern, The University of Sydney, Royal North Shore Hospital, St. Leonards, Australia

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Caterson B (2012) Fell-Muir Lecture: chondroitin sulphate glycosaminoglycans: fun for some and confusion for others. Int J Exp Pathol 93(1):1–10

Coulson-Thomas VJ, Gesteira TF, Esko J, Kao W (2014) Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis. J Biol Chem 289(36):25211–25226

Dawicki W, Marshall JS (2007) New and emerging roles for mast cells in host defence. Curr Opin Immunol 19(1):31–38

Gallagher JT, Turnbull JE (1992) Heparan sulphate in the binding and activation of basic fibroblast growth factor. Glycobiology 2(6):523–580

Hayes AJ, Lord MS, Smith SM, Smith MM, Whitelock JM, Weiss AS, Melrose J (2011a) Colocalization in vivo and association in vitro of perlecan and elastin. Histochem Cell Biol 136(4):437–454. doi: 10.1007/s00418-011-0854-7

Hayes AJ, Smith SM, Gibson MA, Melrose J (2011b) Comparative immunolocalization of the elastin fiber-associated proteins fibrillin-1, LTBP-2, and MAGP-1 with components of the collagenous and proteoglycan matrix of the fetal human intervertebral disc. Spine (Phila Pa 1976) 36(21):E1365–E1372

Hayes AJ, Gibson MA, Shu C, Melrose J (2014) Confocal microscopy demonstrtaes association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix. Tissue Cell 46:185–197

Iozzo RV, Schaefer L (2010) Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans. FEBS J 277(19):3864–3875

Ishijima M, Suzuki N, Hozumi K, Matsunobu T, Kosaki K, Kaneko H, Hassell JR, Arikawa-Hirasawa E, Yamada Y (2012) Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix Biol 31(4):234–245

Isogai Z, Ono RN, Ushiro S, Keene DR, Chen Y, Mazzieri R, Charbonneau NL, Reinhardt DP, Rifkin DB, Sakai LY (2003) Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem 278(4):2750–2757

Jung M, Lord MS, Cheng B, Lyons JG, Alkhouri H, Hughes JM, McCarthy SJ, Iozzo RV, Whitelock JM (2013) Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing. J Biol Chem. doi: 10.1074/jbc.M112.387811

Kitoh A, Nomura T, Kabashima K (2013) TGF-beta 1, an epidermal controller of skin dendritic cell homeostasis. J Invest Dermatol 133:9–11

Knox SM, Whitelock JM (2006) Perlecan: How does one molecule do so many things? Cell Mol Life Sci 63(21):2435–2445

Knox S, Merry C, Stringer S, Melrose J, Whitelock J (2002) Not all perlecans are created equal interactions with fibroblast growth factor (FGF) 2 and FGF receptors. J Biol Chem 277(17):14657–14665

Knox S, Fosang AJ, Last K, Melrose J, Whitelock J (2005) Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan. FEBS Lett 579(22):5019–5023

Kolset SO, Tveit H (2008) Serglycin-structure and biology. Cell Mol Life Sci 65(7–8):1073–1085

Lord MS, Chuang CY, Melrose J, Davies MJ, Iozzo RV, Whitelock JM (2014) The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling. Matrix Biol 35:112–122

Malaviya R, Ikeda T, Ross E, Abraham SN (1996) Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature 381(6577):77–80

Massagué J, Xi Q (2012) TGF-β control of stem cell differentiation genes. FEBS Lett 586(14):1953–1958

Melrose J, Roughley P, Knox S, Smith S, Lord M, Whitelock J (2006) The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages. J Biol Chem 281(48):36905–36914

Melrose J, Hayes AJ, Whitelock JM, Little CB (2008) Perlecan, the “jack of all trades” proteoglycan of cartilaginous weight-bearing connective tissues. BioEssays 30(5):457–469

Melrose J, Isaacs MD, Smith SM, Hughes CE, Little CB, Caterson B, Hayes AJ (2012) Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochem Cell Biol 138(3):461–475

Neill T, Schaefer L, Iozzo RV (2012) Decorin: a guardian from the matrix. Am J Pathol 181(2):380–387

Neill T, Schaefer L, Iozzo RV (2015) Decoding the matrix: instructive roles of proteoglycan receptors. Biochemistry 54(30):4583–4598

Olivera-Martinez I, Viallet JP, Michon F, Pearton DJ, Dhouailly D (2004) The different steps of skin formation in vertebrates. Int J Dev Biol 48:107–115

Rishikaysh P, Dev K, Diaz D, Qureshi WM, Filip S, Mokry J (2014) Signaling involved in hair follicle morphogenesis and development. Int J Mol Sci 15(1):1647–1670

Rossi M, Morita H, Sormunen R, Airenne S, Kreivi M, Wang L, Fukai N, Olsen BR, Tryggvason K, Soininen R (2003) Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney. EMBO J 22(2):236–245

Shu CC, Jackson MT, Smith MM, Smith SM, Penm S, Lord MS, Whitelock JM, Little CB, Melrose J (2015) Perlecan domain I heparan sulfate ablation reduces progressive cartilage degradation, synovitis, and osteophyte size in post-traumatic osteoarthritis. Arthritis Rheumatol. doi: 10.1002/art.39529

Smith MM, Melrose J (2015) Proteoglycans in normal and healing skin. Adv Wound Care (New Rochelle) 4(3):152–173

Sporn MB, Roberts AB (1993) A major advance in the use of growth factors to enhance wound healing. J Clin Invest 92(6):2565–2566

Tanimura S, Tadokoro Y, Inomata K, Binh NT, Nishie W, Yamazaki S, Nakauchi H, Tanaka Y, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK (2011) Hair follicle stem cells provide a functional niche for melanocyte stem cells. Cell Stem Cell 8(2):177–187

Todorovic V, Rifkin DB (2012) LTBPs, more than just an escort service. J Cell Biochem 113(2):410–418

Whitelock J, Melrose J (2011) Heparan sulfate proteoglycans in healthy and diseased systems. Wiley Interdiscip Rev Syst Biol Med 3(6):739–751

Whitelock JM, Melrose J, Iozzo RV (2008) Diverse cell signaling events modulated by perlecan. Biochemistry 47(43):11174–11183

Zhou Z, Wang J, Cao R, Morita H, Soininen R, Chan KM, Liu B, Cao Y, Tryggvason K (2004) Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulphate-deficient mice. Cancer Res 64(14):4699–4702