The global distribution and spread of the mobilized colistin resistance gene mcr-1

Nature Communications - Tập 9 Số 1
Ruobing Wang1, Lucy van Dorp2, Liam P. Shaw2, Phelim Bradley3, Qi Wang1, Xiaojuan Wang1, Longyang Jin1, Qing Zhang4, Yuqing Liu4, Adrien Rieux5, Thamarai Schneiders6, Lucy A. Weinert7, Zamin Iqbal8, Xavier Didelot9, Hui Wang1, François Balloux2
1Department of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, China
2UCL Genetics Institute, University College London, Gower Street, London WC1E 6BT, UK
3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
4Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Shandong Province, Jinan, 250100, China
5UMR PVBMT, CIRAD, 97410, St Pierre, Reunion, France
6Division of Infection and Pathway Medicine, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
7Department of Veterinary Medicine, Cambridge, CB3 0ES, UK
8European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge CB10 1SD, UK
9Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place 21, London, W2 1PG, UK

Tóm tắt

AbstractColistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.

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Tập 9 Số 1

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