The formation of phosphatidylinositol by acylation of 2‐acyl‐<i>sn</i>‐glycero‐3‐phosphorylinositol in rat liver microsomes

Lipids - Tập 14 Số 6 - Trang 529-532 - 1979
Bruce J. Holub1, J. Piekarski1
1Department of Nutrition, College of Biological Science, University of Guelph, Guelph, Ontario, N1G 2W1, Canada

Tóm tắt

AbstractThe conversion of 2‐acyl‐sn‐glycero‐3‐phosphorylinositol into phosphatidylinositol via acyl‐CoA: 2‐acyl‐sn‐glycero‐3‐phosphorylinositol acyltransferase activity was found to occur in rat liver microsomes. Over a wide range of conditions, stearic acid was preferred over palmitate by the acyltransferase when these acids were presented in mixtures as acyl‐CoA derivatives. The potential importance of this enzyme activity for the entry of stearic acid into the 1‐position of hepatic phosphatidylinositol is further supported by its greater preference for stearate relative to the acyl‐CoA: 2‐acyl‐sn‐glycero‐3‐phosphorylcholine acyltransferase under certain assay conditions.

Từ khóa


Tài liệu tham khảo

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10.1016/S0021-9258(18)69403-7

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Lipids

Tập 14 Số 6

529-532

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