The evolution of depression and suicidality in first episode psychosis

Acta Psychiatrica Scandinavica - Tập 122 Số 3 - Trang 211-218 - 2010
Rachel Upthegrove1, Max Birchwood, Kerry Ross, Kaitlin M. Brunett, Richard McCollum, Lisa Jones
1Birmingham and Solihull Mental Health Foundation Trust, Early Intervention Service, Aston, Birmingham, UK. [email protected]

Tóm tắt

Upthegrove R, Birchwood M, Ross K, Brunett K, McCollum R, Jones L. The evolution of depression and suicidality in first episode psychosis.Objective:  To have a clearer understanding of the ebb and flow of depression and suicidal thinking in the early phase of psychosis, whether these events are predictable and how they relate to the early course of psychotic symptoms.Method:  Ninety‐two patients with first episode psychosis (FEP) completed measures of depression, including prodromal depression, self‐harm and duration of untreated psychosis. Follow‐up took place over 12 months.Results:  Depression occurred in 80% of patients at one or more phases of FEP; a combination of depression and suicidal thinking was present in 63%. Depression in the prodromal phase was the most significant predictor of future depression and acts of self‐harm.Conclusion:  Depression early in the emergence of a psychosis is fundamental to the development of future depression and suicidal thinking. Efforts to predict and reduce depression and deliberate self‐harm in psychosis may need to target this early phase to reduce later risk.

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Tài liệu tham khảo

10.1017/S0033291706008221

10.1053/comp.2001.24577

10.1007/s00406-005-0588-4

10.1192/bjp.177.6.522

10.1176/appi.ajp.157.9.1379

10.1017/S0033291704003745

10.1192/bjp.186.5.364

10.1016/S0140-6736(09)60072-6

10.1001/archpsyc.62.3.247

10.1192/bjp.bp.107.037192

10.1093/oxfordjournals.schbul.a007102

10.1192/bjp.181.43.s98

World Health Organization, 1999, SCAN 2.1: Schedules for Clinical Assessment in Neuropsychiatry

10.1093/schbul/13.2.261

10.1037/1040-3590.18.3.303

10.1093/schbul/22.2.241

10.1192/pb.bp.106.013995

http://www.bnf.org.

Addington D, 1993, Assessing depression in schizophrenia: the Calgary Depression Scale, Br J Psychiatry Suppl, 39, 10.1192/S0007125000292581

10.1016/0920-9964(92)90003-N

Górna K, 2007, Quality of life and depression in schizophrenic patients, Adv Med Sci, 52, 108

10.1176/ajp.150.11.1643

10.1192/bjp.177.6.516

10.1192/bjp.bp.108.053124

10.1192/bjp.bp.108.054239

10.1192/bjp.191.51.s31

10.1111/j.1600-0447.2009.01372.x

10.1007/s00406-005-0582-x

10.1017/S0033291706008774

10.1016/0920-9964(88)90036-9

10.1192/bjp.bp.104.007294

10.1016/j.schres.2006.05.001

10.1176/appi.ajp.159.3.443

10.1348/014466504X19767

10.1093/oxfordjournals.schbul.a033499

10.1016/S0920-9964(02)00167-6

10.1034/j.1600-0447.2003.00059.x

10.1521/suli.35.1.50.59260

10.1176/ajp.2006.163.5.800

10.1111/j.1600-0447.1999.tb10847.x

Nishida A, 2009, Psychotic‐like experiences are associated with suicidal feelings and deliberate self‐harm behaviors in adolescents aged 12–15 years, Acta Psychiatr Scand, 9999

10.1111/j.1600-0447.2008.01338.x

10.1111/j.1440-1614.2006.01860.x

10.1111/j.1600-0447.2009.01344.x