The efficacy and safety of direct-acting antiviral drugs in the management of hepatitis C virus-related arthritis

Egyptian Rheumatology and Rehabilitation - Tập 47 - Trang 1-8 - 2020
Samah M. Alian1, Mohamed Othman Wahba2, Ahmed Fathy Gomaa2, Sahar S. Khalil1,3
1Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Physical Medicine and Rehabilitation Department, Dubai Hospital, Dubai, United Arab Emirates

Tóm tắt

Hepatitis C virus (HCV) infection is a worldwide disease. HCV-related arthritis is one of the extrahepatic manifestations of the disease. The treatment of chronic HCV has been revolutionized with the introduction of oral direct-acting antiviral (DAA) drugs. We aim to determine the outcomes of treatment by the combination of sofosbuvir-daclatasvir with or without ribavirin in patients with HCV-related arthritis. Post-therapy, all group I patients had sustained viral response. Significant improvement of the outcome parameters was found 12 weeks post-treatment in group I compared to baseline and group II. Complete and partial remission of articular symptoms in group I patients was observed in 80% and 5%, respectively, while 85% of patients in group II showed no remission. Few mild side effects were encountered with therapy. The combination of sofosbuvir-daclatasvir with or without ribavirin is an effective and safe therapy for eradication of HCV infection and amelioration of HCV-related arthritis.

Tài liệu tham khảo

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