The effects on thermal lesion shape and size from bubble clouds produced by acoustic droplet vaporization

Springer Science and Business Media LLC - 2018
Ying Xin1, Aili Zhang1, Lisa X. Xu1, J. Brian Fowlkes2
1School of Biomedical Engineering, 400 Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China
2Department of Radiology, University of Michigan Health System, Ann Arbor, USA

Tóm tắt

Bubbles formed by acoustic droplet vaporization (ADV) have proven to be an effective method for significant enlargement of the thermal lesions produced by high intensity focused ultrasound (HIFU). We investigated the influences of bubble cloud shape and droplet concentration on HIFU thermal lesions, as these relate to the ADV technique. Unlike previous studies where the droplets were simultaneously vaporized with the HIFU exposure for thermal lesion formation, droplets were vaporized by pulse wave (PW) ultrasound prior to continuous wave (CW) ultrasound heating in this experimental study. Under different experimental conditions, we recorded and quantified by the image processing methods the morphology and size of the bubble clouds created and the corresponding thermal lesions formed. The results demonstrated that different ADV droplet concentrations produced a variety of thermal lesion shapes and sizes. The lesion volume could be increased using PW ultrasound followed by CW exposure, especially for higher droplet concentrations, e.g. 3.41 × 106/mL yielded a tenfold increase over that seen using CW alone. These findings could lead to optimization of HIFU therapy by selecting a bubble forming strategy and droplet concentrations, especially using lower ultrasound powers which is desirable in clinical applications.

Từ khóa


Tài liệu tham khảo

Kennedy J, ter Haar G, Cranston D. High intensity focused ultrasound: surgery of the future? Br J Radiol. 2003;76:590–9.

Napoli A, Anzidei M, Ciolina F, et al. Mr-guided high-intensity focused ultrasound: current status of an emerging technology. Cardiovasc Interv Radiol. 2013;36:1190–203.

Lafon C, Zderic V, Noble ML, et al. Gel phantom for use in high-intensity focused ultrasound dosimetry. Ultrasound Med Biol. 2005;31:1383–9.

Takegami K, Kaneko Y, Watanabe T, et al. Heating and coagulation volume obtained with high-intensity focused ultrasound therapy: comparison of perflutren protein-type a microspheres and mrx-133 in rabbits 1. Radiology. 2005;237:132–6.

Umemura S-I, Kawabata K-I, Sasaki K. In vivo acceleration of ultrasonic tissue heating by microbubble agent. IEEE Trans Ultrason Ferroelectr Freq Control. 2005;52:1690–8.

Tung Y-S, Liu H-L, Wu C-C, et al. Contrast-agent-enhanced ultrasound thermal ablation. Ultrasound Med Biol. 2006;32:1103–10.

Luo W, Zhou X, Ren X, et al. Enhancing effects of sonovue, a microbubble sonographic contrast agent, on high-intensity focused ultrasound ablation in rabbit livers in vivo. J Ultrasound Med. 2007;26:469–76.

Luo W, Zhou X, He G, et al. Ablation of high intensity focused ultrasound combined with sonovue on rabbit vx2 liver tumors: assessment with conventional gray-scale us, conventional color/power doppler us, contrast-enhanced color doppler us, and contrast-enhanced pulse-inversion harmonic us. Ann Surg Oncol. 2008;15:2943–53.

Coussios C, Farny C, Ter Haar G, et al. Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (hifu). Int J Hyperthermia. 2007;23:105–20.

Kripfgans OD, Fowlkes JB, Miller DL, et al. Acoustic droplet vaporization for therapeutic and diagnostic applications. Ultrasound Med Biol. 2000;26:1177–89.

Zhang M, Fabiilli ML, Haworth KJ, et al. Acoustic droplet vaporization for enhancement of thermal ablation by high intensity focused ultrasound. Acad Radiol. 2011;18:1123–32.

Zhu M, Jiang L, Fabiilli ML, et al. Treatment of murine tumors using acoustic droplet vaporization-enhanced high intensity focused ultrasound. Phys Med Biol. 2013;58:6179.

Lo AH, Kripfgans OD, Carson PL, et al. Spatial control of gas bubbles and their effects on acoustic fields. Ultrasound Med Biol. 2006;32:95–106.

Moyer LC, Timbie KF, Sheeran PS, et al. High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles. J Ther Ultrasound. 2015;3:7.

Kripfgans OD, Zhang M, Fabiilli ML, et al. Acceleration of ultrasound thermal therapy by patterned acoustic droplet vaporization. J Acoust Soc Am. 2014;135:537–44.

Commander KW, Prosperetti A. Linear pressure waves in bubbly liquids: comparison between theory and experiments. J Acoust Soc Am. 1989;85:732–46.

Rosnitskiy P, Yuldashev P, Vysokanov B, et al. Setting boundary conditions on the khokhlov–zabolotskaya equation for modeling ultrasound fields generated by strongly focused transducers. Acoust Phys. 2016;62:151–9.

Del Grosso V, Mader C. Speed of sound in pure water. J Acoust Soc Am. 1972;52:1442–6.

Pinkerton J. A pulse method for the measurement of ultrasonic absorption in liquids: results for water. Nature. 1947;160:128–9.

Takegami K, Kaneko Y, Watanabe T, et al. Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound. Ultrasound Med Biol. 2004;30:1419–22.

Ridler T, Calvard S. Picture thresholding using an iterative selection method. IEEE Trans Syst Man Cybern. 1978;8:630–2.

Silver WM. Normalized correlation search in alignment, gauging, and inspection. In: Proceedings of the image pattern recognition: algorithm implementations, techniques, and technology, 1987. International Society for Optics and Photonics.

Hsieh DY, Plesset MS. Theory of rectified diffusion of mass into gas bubbles. J Acoust Soc Am. 1961;33:206–15.

Crum L, Hansen G. Growth of air bubbles in tissue by rectified diffusion. Phys Med Biol. 1982;27:413.

Xin Y, Zhang A, Xu LX, et al. Numerical study of bubble area evolution during acoustic droplet vaporization-enhanced hifu treatment. J Biomech Eng. 2017;139:091004.

Zhang P, Kopechek JA, Porter TM. The impact of vaporized nanoemulsions on ultrasound-mediated ablation. J Ther Ultrasound. 2013;1:2.

Thông tin
Thông tin xuất bản

Springer Science and Business Media LLC

Thông tin tác giả