The effect of antioxidant deficiency on tissue lipid composition in the rat. I. Gastrocnemius and quadriceps muscle

Lipids - 1967
Lloyd A. Witting1, M. K. Horwitt1
1L. B. Mendel Research Laboratory, Elgin State Hospital, Elgin, Illinois

Tóm tắt

AbstractThe gastrocnemius and quadriceps muscle phospholipids of the antioxidant‐deficient rat fed a source of both linoleate and linolenate showed a progressive net increase in arachidonate, a progressive net decrease in all other polyunsaturated fatty acids, and there was a concomitant accumulation of fluorescent pigment of the lipofuscin or ceroid type in the tissue. An increased incorporation of intraperitoneally injected, isotopically labeled acetate into not only arachidonate but also the other higher polyunsaturated fatty acids, was observed. The net loss of the higher polyunsaturated fatty acids from the membrane lipids (presumably via lipid peroxidation) apparently was partially compensated by a homeostatic mechanism which involved conversion of the available precursors, linoleate and linolenate, to the higher polyunsaturated fatty acids. The rates of decrease of the polyunsaturated fatty acids in the muscle phospholipids and accumulation of fluorescent pigment in the tissue were correlated with the rate of production of creatinuria.

Từ khóa


Tài liệu tham khảo

10.1093/jn/82.1.19

10.1093/jn/84.4.351

Witting L. A., 1965, Federation Proc., 24, 912

10.1007/BF02632443

10.1093/jn/56.2.173

10.1002/hlca.19630460534

Horwitt M. K., 1965, Federation Proc., 24, 68

10.1002/ar.1090920104

10.1002/ar.1090940305

Century B., 1965, Federation Proc., 24, 906

10.1016/S0021-9258(19)51334-5

10.1093/geronj/14.4.430

10.1016/S0022-2275(20)40488-2

Zilversmit D. B., 1950, J. Lab. Clin. Med., 35, 155

10.1007/BF02633061

10.1016/S0022-2275(20)40299-8

Clayton M. M., 1959, Clin. Med., 5, 426

10.1007/BF02530906

10.1007/BF02530906

10.1007/BF02530908

Youden W. J., 1951, Statistical Methods for Chemists

Woodman A. G., 1941, Food Analysis, 185

10.1093/ajcn/18.4.243

10.1016/S0021-9258(18)70021-5

Hartroft W. S., 1963, Federation Proc., 22, 250

10.1126/science.113.2946.673

Endicott K. M., 1944, Arch. Pathol., 37, 49

10.1084/jem.94.6.549

10.1016/0003-9861(55)90039-4

Thông tin
Thông tin xuất bản

Lipids

Thông tin tác giả