Vai trò đối lập của IL-2 và IL-15 trong sự sống và cái chết của tế bào lympho: những hệ quả cho liệu pháp miễn dịch trong các bệnh khớp

Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol. 1996, 14: 397-440. 10.1146/annurev.immunol.14.1.397. McInnes IB, al-Mughales J, Field M, Leung BP, Huang FP, Dixon R, Sturrock RD, Wilkinson PC, Liew FY: The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med. 1996, 2: 175-182. McInnes IB, Leung BP, Sturrock RD, Field M, Liew FY: Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nat Med. 1997, 3: 189-195. Harada S, Yamamura M, Okamoto H, Morita Y, Kawahima M, Aita T, Makino Y: Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum. 1999, 42: 1508-1516. 10.1002/1529-0131(199907)42:7<1508::AID-ANR26>3.0.CO;2-L. Kirmar I, Vaener B, Nielsen OH: Interleukin-15 and its role in chronic inflammatory diseases. Inflamm Res. 1998, 47: 285-289. 10.1007/s000110050331. Oppenheimer-Marks N, Brezinschek RI, Mohamadzadeh M, Vita R, Lipsky PE: Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells in vitro and in the SCID mouse-human rheumatoid arthritis model in vivo. J Clin Invest. 1998, 101: 1261-1272. Klimiuk PA, Sierakowski S, Latosiewicz R, Cylioik B, Skowronski J, Chwiecko J: Serum cytokines in different histological variants of rheumatoid arthritis. J Rheumatol. 2001, 28: 1211-1217. McInnes IB, Liew FY: Interleukin 15: A proinflamatory role in rheumatoid arthritis synovitis. Immunol Today. 1998, 19: 75-79. 10.1016/S0167-5699(97)01205-X. Ruchatz H, Leung BP, Wei XQ, McInnes IB, Liew FY: Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunotherapy. J Immunol. 1998, 160: 5654-5660. Kim YS, Maslinski W, Zheng XX, Stevens AC, Li XC, Tesch GH, Kelley VR, Strom TB: Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc γ2a protein blocks delayed-type hypersensitivity. J Immunol. 1998, 160: 5742-5748. Waldmann TA: The interleukin-2 receptor. J Biol Chem. 1991, 266: 2681-2684. Bamford RN, Grant AJ, Burton JD, Peters C, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA: The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci U S A. 1994, 91: 4940-4944. Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M, Johnson L, Alderson MR, Watson JD, Anderson DM, Giri JG: Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science. 1994, 264: 965-968. Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM: Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995, 14: 3654-3663. Zhang X, Sun S, Hwang I, Tough DF, Sprent J: Potent and selective stimulation or memory-phenotype CD8+ T cells in vivo by IL-15. Immunity. 1998, 8: 591-599. Ku CC, Murakami M, Sakamoto A, Kappler J, Marrack P: Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science. 2000, 288: 675-678. 10.1126/science.288.5466.675. Marks-Konczalik J, Dubois S, Losi JM, Sabzevari H, Yamada N, Feigenbaum L, Waldmann TA, Tagaya Y: IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc Natl Acad Sci U S A. 2000, 97: 11445-11450. 10.1073/pnas.200363097. Waldmann TA, Dubois S, Tagaya Y: Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity. 2001, 14: 105-110. 10.1016/S1074-7613(01)00120-0. Waldmann T, Tagaya Y: The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Ann Rev Immunol. 1999, 17: 19-49. 10.1146/annurev.immunol.17.1.19. Lenardo MJ: Fas and the art of lymphocyte maintenance. J Exp Med. 1996, 183: 721-724. Kirman I, Nielsen OH: Increased numbers of interleukin-15 expressing cells in active ulcerative colitis. Am J Gastroenterol. 1996, 91: 1789-1794. Kivisakk P, Matusevicius D, He B, Soderstrom M, Fredrikson S, Link H: IL-15 mRNA expression is up-regulated in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis (MS). Clin Exp Immunol. 1998, 111: 193-197. 10.1046/j.1365-2249.1998.00478.x. Azimi N, Brown K, Bamford RN, Tagaya Y, Siebenlist U, Waldmann TA: Human T cell lymphotropic virus type I Tax protein transactiviates interleukin 15 gene transcription through an NF-kappaB site. Proc Natl Acad Sci U S A. 1998, 95: 2452-2457. 10.1073/pnas.95.5.2452. Azimi N, Jacobson S, Leist T, Waldmann TA: Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15Rβ receptor. J Immunol. 1999, 163: 4064-4072. Burton JD, Bamford RN, Peters C, Grant AJ, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA: A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci U S A. 1994, 91: 4935-4939. Bamford RN, DeFilippis AP, Azimi N, Kurys G, Waldmann TA: The 5' untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control. J Immunol. 1998, 160: 4418-4426. Onu A, Pohl T, Krause H, Bulfone-Paus S: Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms. J Immunol. 1997, 158: 255-262. Kurys G, Tagaya Y, Bamford R, Hanover JA, Waldmann TA: The long signal peptide isoform and its alternative processing direct the intracellular trafficking of IL-15. J Biol Chem. 2000, 275: 30653-30659. 10.1074/jbc.M002373200. Kennedy MK, Park LS: Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex. J Clin Immunol. 1996, 16: 134-143. Inagaki-Ohara K, Nishimura H, Mitani A, Yoshikai Y: Interluekin-15 preferentially promotes the growth of intestinal intraep-ithelial lymphocytes bearing gamma delta T cell receptor in mice. Eur J Immunol. 1997, 27: 2885-2891. Carson WE, Ross ME, Baiocchi RA, Marien MJ, Boiani N, Grab-stein K, Caligiuri MA: Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. J Clin Invest. 1995, 96: 2578-2582. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH: IL-15 has stimulatory activitity for the induction of B cell proliferation and differentiation. J Immunol. 1995, 154: 483-490. Azimi N, Nagai M, Jacobson S, Waldmann T: Interleukin 15 is an essential factor for the persistence of the Tax-specific CD8 cells in HAM/TSP patients. Proc Natl Acad Sci U S A. Sadlack B, Kuhn R, Schorle H, Rajewsky K, Muller W, Horak I: Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and-4. Eur J Immunol. 1994, 24: 281-284. Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW: Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 1995, 3: 521-530. 10.1016/1074-7613(95)90180-9. Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulis T, Trettin S, Ma A: IL-15 receptor maintains lymphoid hemeostatsis by supporting lymphocyte homing and proliferation. Immunity. 1998, 9: 668-676. Kennedy MK, Glaccum M, Brown SN, Butz EA, Viney JL, Embers M, Matsuki N, Charrier K, Sedger L, Willis CR, Brasel K, Morrissey PJ, Stocking K, Schuh JC, Joyce S, Peschon JJ: Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med. 2000, 191: 771-780. 10.1084/jem.191.5.771. Mariner JM, Lantz V, Waldmann TA, Azimi N: Human T cell lymphotropic virus type I Tax protein activates interleukin 15 receptor alpha gene expression through the action of NF-κB. J Immunol. 2001, 166:2: 602-2609. Ziolkowska M, Koc A, Luszczkiewicz G, Ksiezopolska-Pietrzak K, Klimczak E, Chawalinska-Sadowska H, Maslinski W: High levels of IL-17 in rheumatoid arthritis patients; IL-15 triggers in vitro IL-17 production via cydosporin A-sensitive mechanism. J Immunol. 2000, 164: 2832-2838. Waldmann TA, White JD, Goldman CK, Top L, Grant A, Bamford R, Roessler E, Horak ID, Zaknoen S, Kasten-Sportes C, England R, Horak E, Mishra B, Dipre M, Hale P, Fleisher TA, Junghans RP, Jaffe ES, Nelson DL: The interleukin receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia. Blood. 1993, 82: 1701-1712. Shevach EM: Certified professionals: CD4+ CD25+ suppressor T cells. J Exp Med. 2001, 193: F41-F45. 10.1084/jem.193.11.F41. Tinubu SA, Hakimi J, Kondas JA, Bailon P, Familletti PC, Spence C, Crittenden MD, Parenteau GL, Dirbas FM, Tsudo M, Bacher JD, Kasten-Sportès C, Martinucci JL, Goldman CK, Clark RE, Waldmann TA: A humanized antibody directed to the interleukin-2 receptor β chain prolongs primate cardiac allograft survival. J Immunol. 1994, 153: 4330-4338. Tsudo M, Goldman CK, Bongiovanni KF, Chan WC, Winton EF, Yagita M, Grimm EA, Waldmann TA: The p75 peptide is the receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells. Proc Natl Acad Sci U S A. 1987, 84: 5394-5398. Russsell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, Migone TS, Noguchi M, Markert ML, Buckley RH, O'Shea JJ, Leonard WJ: Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science. 1995, 270: 797-800. Macchi P, Villa A, Gillani S, Sacco MG, Frattini A, Porta F, Ugazio AG, Johnston JA, Candotti F, O'Shea JJ, Vezzoni P, Notarangelo LD: Mutations of Jak3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature. 1995, 377: 65-68. Nosaka T, van Deursen JM, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN: Defective lymphoid development in mice lacking Jak3. Science. 1995, 270: 800-802. Migone TS, Lin JX, Cereseto A, Mulloy JC, O'Shea JJ, Franchini G, Leonard WJ: Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-1. Science. 1995, 269: 79-81. Xu X, Kang SH, Heidenreich O, Okerholm M, O'Shea JJ, Nerenberg MI: Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type I (HTLV-1) tax protein or virus-transformed cells. J Clin Invest. 1995, 96: 1548-1555.