Hệ thống renin-angiotensin trung ương và hoạt động dây thần kinh giao cảm trong suy tim mạn tính

Roger, 2011, Heart disease and stroke statistics–2012 update: a report from the American Heart Association, Circulation, 125, e2

Dzau, 1981, Relation of the renin–angiotensin–aldosterone system to clinical state in congestive heart failure, Circulation, 63, 645, 10.1161/01.CIR.63.3.645

Francis, 1989, The relationship of the sympathetic nervous system and the renin–angiotensin system in congestive heart failure, Am. Heart J., 118, 642, 10.1016/0002-8703(89)90291-3

Holtz, 1993, Pathophysiology of heart failure and the renin–angiotensin–system, Basic Res. Cardiol., 88, 183

Bristow, 1992, β-Adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms, J. Clin. Invest., 89, 803, 10.1172/JCI115659

Bristow, 1986, β1- and β2-Adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective β1-receptor down-regulation in heart failure, Circ. Res., 59, 297, 10.1161/01.RES.59.3.297

Freeman, 2001, Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy, J. Clin. Invest., 107, 967, 10.1172/JCI12083

Ljungman, 1990, Role of the kidney in congestive heart failure. Relationship of cardiac index to kidney function, Drugs, 39, 10, 10.2165/00003495-199000394-00004

Sobotka, 2012, The role of renal denervation in the treatment of heart failure, Curr. Cardiol. Rep., 14, 285, 10.1007/s11886-012-0258-x

Felder, 2003, Heart failure and the brain: new perspectives, Am. J. Physiol. Regul. Integr. Comp. Physiol., 284, R259, 10.1152/ajpregu.00317.2002

Francis, 2004, Brain angiotensin-converting enzyme activity and autonomic regulation in heart failure, Am. J. Physiol. Heart Circ. Physiol., 287, H2138, 10.1152/ajpheart.00112.2004

Hegarty, 1996, Influence of circulating angiotensin II and vasopressin on neurons of the nucleus of the solitary tract, Am. J. Physiol. Regul. Integr. Comp. Physiol., 270, R675, 10.1152/ajpregu.1996.270.3.R675

Huang, 2009, The brain renin–angiotensin–aldosterone system: a major mechanism for sympathetic hyperactivity and left ventricular remodeling and dysfunction after myocardial infarction, Curr. Heart Fail. Rep., 6, 81, 10.1007/s11897-009-0013-9

Zucker, 2004, The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxide, Prog. Biophys. Mol. Biol., 84, 217, 10.1016/j.pbiomolbio.2003.11.010

Bains, 1992, Angiotensin II actions in paraventricular nucleus: functional evidence for neurotransmitter role in efferents originating in subfornical organ, Brain Res., 599, 223, 10.1016/0006-8993(92)90395-P

Chen, 2011, AT1 receptors in the paraventricular nucleus mediate the hyperthermia-induced reflex reduction of renal blood flow in rats, Am. J. Physiol. Regul. Integr. Comp. Physiol., 300, R479, 10.1152/ajpregu.00604.2010

Gao, 2005, Sympathoexcitation by central Ang II: roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM, Am. J. Physiol. Heart Circ. Physiol., 288, H2271, 10.1152/ajpheart.00949.2004

Gao, 2008, Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: potential mechanism for sympathetic overactivity in heart failure, Hypertension, 52, 708, 10.1161/HYPERTENSIONAHA.108.116228

Head, 1996, Role of AT1 receptors in the central control of sympathetic vasomotor function, Clin. Exp. Pharmacol. Physiol., 23, S93, 10.1111/j.1440-1681.1996.tb02820.x

Ito, 2002, Ventrolateral medulla AT1 receptors support blood pressure in hypertensive rats, Hypertension, 40, 552, 10.1161/01.HYP.0000033812.99089.92

Kleiber, 2010, Chronic AT1 receptor blockade normalizes NMDA-mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN in rats with heart failure, Am. J. Physiol. Heart Circ. Physiol., 298, H1546, 10.1152/ajpheart.01006.2009

McKinley, 2003, The brain renin–angiotensin system: location and physiological roles, Int. J. Biochem. Cell Biol., 35, 901, 10.1016/S1357-2725(02)00306-0

Patel, 2011, Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion, Am. J. Physiol. Regul. Integr. Comp. Physiol., 300, R311, 10.1152/ajpregu.00246.2010

Wang, 2008, Sex differences in angiotensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla, Am. J. Physiol. Regul. Integr. Comp. Physiol., 295, R1149, 10.1152/ajpregu.90485.2008

Zhu, 2004, Ang II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure, J Appl. Physiol., 97, 1746, 10.1152/japplphysiol.00573.2004

Liu, 1999, Regulation of sympathetic nerve activity in heart failure: a role for nitric oxide and angiotensin II, Circ. Res., 84, 417, 10.1161/01.RES.84.4.417

Zucker, 2001, The regulation of sympathetic outflow in heart failure, Neuro-Cardiovascular Regulation, 431

Gao, 2004, Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase, Circ. Res., 95, 937, 10.1161/01.RES.0000146676.04359.64

Liu, 2008, Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neurons, Circ. Res., 103, 186, 10.1161/CIRCRESAHA.108.179408

Guggilam, 2011, Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxide, Basic Res. Cardiol., 106, 273, 10.1007/s00395-010-0146-8

Huang, 2011, Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone, Exp. Physiol., 96, 1028, 10.1113/expphysiol.2011.059840

Zhu, 2004, AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure, Am. J. Physiol. Heart Circ. Physiol., 287, H1828, 10.1152/ajpheart.01245.2003

Wang, 2012, Angiotensin II, sympathetic nerve activity and chronic heart failure, Heart Fail. Rev.

Yoshimura, 2000, Increased brain angiotensin receptor in rats with chronic high-output heart failure, J. Card. Fail., 6, 66, 10.1016/S1071-9164(00)00013-0

DiBona, 1995, Ang II receptor blockade and arterial baroreflex regulation of renal nerve activity in cardiac failure, Am. J. Physiol. Regul. Integr. Comp. Physiol., 269, R1189, 10.1152/ajpregu.1995.269.5.R1189

Zhang, 1999, Brain renin–angiotensin system and sympathetic hyperactivity in rats after myocardial infarction, Am. J. Physiol. Heart Circ. Physiol., 276, H1608, 10.1152/ajpheart.1999.276.5.H1608

Wang, 2004, Prevention of sympathetic and cardiac dysfunction after myocardial infarction in transgenic rats deficient in brain angiotensinogen, Circ. Res., 94, 843, 10.1161/01.RES.0000120864.21172.5A

Liu, 2006, Neuronal angiotensin II type 1 receptor upregulation in heart failure: activation of activator protein 1 and Jun N-terminal kinase, Circ. Res., 99, 1004, 10.1161/01.RES.0000247066.19878.93

Liu, 2000, Chronic exercise reduces sympathetic nerve activity in rabbits with pacing-induced heart failure: a role for angiotensin II, Circulation, 102, 1854, 10.1161/01.CIR.102.15.1854

Mitra, 2011, Convergence of p38MAPK pathway and nuclear signals involving NFκB/CREB following Ang II stimulation in neurons, FASEB J., 25, 843.16

Kang, 2009, Brain nuclear factor-κB activation contributes to neurohumoral excitation in angiotensin II-induced hypertension, Cardiovasc. Res., 82, 503, 10.1093/cvr/cvp073

Elks, 2009, Chronic NF-κB blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR, Am. J. Physiol. Renal Physiol., 296, F298, 10.1152/ajprenal.90628.2008

Sumners, 1998, Neuronal ion channel signalling pathways: modulation by angiotensin II, Cell. Signal., 10, 303, 10.1016/S0898-6568(97)00133-2

Sumners, 1996, Angiotensin II type 1 receptor modulation of neuronal K+ and Ca2+ currents: intracellular mechanisms, Am. J. Physiol. Cell Physiol., 271, C154, 10.1152/ajpcell.1996.271.1.C154

Zhu, 1997, Modulation of K+ and Ca2+ currents in cultured neurons by an angiotensin II type 1a receptor peptide, Am. J. Physiol. Cell Physiol., 273, C1040, 10.1152/ajpcell.1997.273.3.C1040

Gao, 2010, Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure, Am. J. Physiol. Heart Circ. Physiol., 298, H945, 10.1152/ajpheart.00145.2009

Jin, 2010, KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling, J. Mol. Cell. Cardiol., 48, 1169, 10.1016/j.yjmcc.2009.12.019

Li, 2008, Regulation of Kv4 channel expression in failing rat heart by the thioredoxin system, Am. J. Physiol. Heart Circ. Physiol., 295, H416, 10.1152/ajpheart.91446.2007

Ozgen, 2012, Microtubules and angiotensin II receptors contribute to modulation of repolarization induced by ventricular pacing, Heart Rhythm, 9, 1865, 10.1016/j.hrthm.2012.07.014

Donoghue, 2000, A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9, Circ. Res., 87, E1, 10.1161/01.RES.87.5.e1

Ferrario, 1988, A hypothesis regarding the function of angiotensin peptides in the brain, Clin. Exp. Hypertens. A, 10, 107

Ferreira, 2012, New cardiovascular and pulmonary therapeutic strategies based on the angiotensin-converting enzyme 2/angiotensin-(1–7)/mas receptor axis, Int. J. Hypertens., 2012, 147825

Feng, 2009, Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension, Circ. Res., 106, 373, 10.1161/CIRCRESAHA.109.208645

Xia, 2009, Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice, Hypertension, 53, 210, 10.1161/HYPERTENSIONAHA.108.123844

Shenoy, 2011, ACE2, a promising therapeutic target for pulmonary hypertension, Curr. Opin. Pharmacol., 11, 150, 10.1016/j.coph.2010.12.002

Zimmerman, 2012, Angiotensin-(1–7) in kidney disease: a review of the controversies, Clin. Sci., 123, 333, 10.1042/CS20120111

Qian, 2013, Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition, Oncol. Rep., 29, 2408, 10.3892/or.2013.2370

Gallagher, 2004, Inhibition of human lung cancer cell growth by angiotensin-(1–7), Carcinogenesis, 25, 2045, 10.1093/carcin/bgh236

Krishnan, 2013, Angiotensin-(1–7) attenuates metastatic prostate cancer and reduces osteoclastogenesis, Prostate, 73, 71, 10.1002/pros.22542

Doobay, 2007, Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system, Am. J. Physiol. Regul. Integr. Comp. Physiol., 292, R373, 10.1152/ajpregu.00292.2006

Hamming, 2004, Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis, J. Pathol., 203, 631, 10.1002/path.1570

Xiao, 2011, Brain-selective overexpression of angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failure, Hypertension, 58, 1057, 10.1161/HYPERTENSIONAHA.111.176636

Zheng, 2011, Angiotensin-converting enzyme 2 overexpression improves central nitric oxide-mediated sympathetic outflow in chronic heart failure, Am. J. Physiol. Heart Circ. Physiol., 301, H2402, 10.1152/ajpheart.00330.2011

Sharma, 2012, Nitric oxide inhibits the expression of AT1 receptors in neurons, Am. J. Physiol. Cell Physiol., 302, C1162, 10.1152/ajpcell.00258.2011

Potts, 2000, The cardiovascular effects of angiotensin-(1–7) in the rostral and caudal ventrolateral medulla of the rabbit, Brain Res., 877, 58, 10.1016/S0006-8993(00)02626-3

Silva, 2005, Blockade of endogenous angiotensin-(1–7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone, Hypertension, 46, 341, 10.1161/01.HYP.0000179216.04357.49

Xia, 2011, ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function, PLoS ONE, 6, e22682, 10.1371/journal.pone.0022682

Diz, 2008, Angiotensin-(1–7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats, J. Cardiovasc. Pharmacol., 51, 542, 10.1097/FJC.0b013e3181734a54

Kar, 2011, Central angiotensin (1–7) enhances baroreflex gain in conscious rabbits with heart failure, Hypertension, 58, 627, 10.1161/HYPERTENSIONAHA.111.177600

Pina, 2003, Exercise and heart failure: a statement from the American Heart Association Committee on exercise, rehabilitation, and prevention, Circulation, 107, 1210, 10.1161/01.CIR.0000055013.92097.40

Belardinelli, 1998, Effects of moderate exercise training on thallium uptake and contractile response to low-dose dobutamine of dysfunctional myocardium in patients with ischemic cardiomyopathy, Circulation, 97, 553, 10.1161/01.CIR.97.6.553

Belardinelli, 1999, Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome, Circulation, 99, 1173, 10.1161/01.CIR.99.9.1173

Georgiou, 2001, Cost-effectiveness analysis of long-term moderate exercise training in chronic heart failure, Am. J. Cardiol., 87, 984, 10.1016/S0002-9149(01)01434-5

Belardinelli, 2001, Exercise training intervention after coronary angioplasty: the ETICA trial, J. Am. Coll. Cardiol., 37, 1891, 10.1016/S0735-1097(01)01236-0

Kitzman, 2010, Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial, Circ. Heart Fail., 3, 659, 10.1161/CIRCHEARTFAILURE.110.958785

Brubaker, 2009, Endurance exercise training in older patients with heart failure: results from a randomized, controlled, single-blind trial, J. Am. Geriatr. Soc., 57, 1982, 10.1111/j.1532-5415.2009.02499.x

Mousa, 2008, Exercise training enhances baroreflex sensitivity by an angiotensin II-dependent mechanism in chronic heart failure, J. Appl. Physiol., 104, 616, 10.1152/japplphysiol.00601.2007

Liu, 2002, Exercise training enhances baroreflex control of heart rate by a vagal mechanism in rabbits with heart failure, J. Appl. Physiol., 92, 2403, 10.1152/japplphysiol.00039.2002

Haack, 2012, Parallel changes in neuronal AT1R and GRK5 expression following exercise training in heart failure, Hypertension, 60, 354, 10.1161/HYPERTENSIONAHA.112.195693

Roveda, 2003, The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial, J. Am. Coll. Cardiol., 42, 854, 10.1016/S0735-1097(03)00831-3

Antunes-Correa, 2010, Impact of gender on benefits of exercise training on sympathetic nerve activity and muscle blood flow in heart failure, Eur. J. Heart Fail., 12, 58, 10.1093/eurjhf/hfp168

de Mello Franco, 2006, Effects of home-based exercise training on neurovascular control in patients with heart failure, Eur. J. Heart Fail., 8, 851, 10.1016/j.ejheart.2006.02.009

Fraga, 2007, Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol, Eur. J. Heart Fail., 9, 630, 10.1016/j.ejheart.2007.03.003

Zheng, 2012, Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: role of angiotensin II, Am. J. Physiol. Regul. Integr. Comp. Physiol., 303, R387, 10.1152/ajpregu.00046.2012

Bertagnolli, 2008, Exercise training reduces sympathetic modulation on cardiovascular system and cardiac oxidative stress in spontaneously hypertensive rats, Am. J. Hypertens., 21, 1188, 10.1038/ajh.2008.270

Gao, 2007, Exercise training normalizes sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failure, Circulation, 115, 3095, 10.1161/CIRCULATIONAHA.106.677989

Kishi, 2012, Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats, Clin. Exp. Hypertens., 34, 278, 10.3109/10641963.2012.681084

Wang, 2013, Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems, Curr. Neurovasc. Res., 10, 81, 10.2174/156720213804805963

Coats, 1992, Controlled trial of physical training in chronic heart failure. Exercise performance, hemodynamics, ventilation, and autonomic function, Circulation, 85, 2119, 10.1161/01.CIR.85.6.2119

Kar, 2010, Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure, J. Appl. Physiol., 108, 923, 10.1152/japplphysiol.00840.2009

Evangelista, 2003, Duration-controlled swimming exercise training induces cardiac hypertrophy in mice, Braz. J. Med. Biol. Res., 36, 1751, 10.1590/S0100-879X2003001200018

Fernandes, 2011, Aerobic exercise training-induced left ventricular hypertrophy involves regulatory microRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1–7), Hypertension, 58, 182, 10.1161/HYPERTENSIONAHA.110.168252

Yang, 2011, Angiotensin-(1–7) increases neuronal potassium current via a nitric oxide-dependent mechanism, Am. J. Physiol. Cell Physiol., 300, C58, 10.1152/ajpcell.00369.2010

Xiao, 2013, Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling, Am. J. Physiol. Cell Physiol., 304, C1073, 10.1152/ajpcell.00364.2012

Burrell, 2012, Chronic kidney disease: cardiac and renal angiotensin-converting enzyme (ACE) 2 expression in rats after subtotal nephrectomy and the effect of ACE inhibition, Exp. Physiol., 97, 477, 10.1113/expphysiol.2011.063156

Sriramula, 2013, Inhibition of TNF in the brain reverses alterations in RAS components and attenuates angiotensin II-induced hypertension, PLoS ONE, 8, e63847, 10.1371/journal.pone.0063847

Wakahara, 2007, Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio, Endocrinology, 148, 2453, 10.1210/en.2006-1287

Zhang, 2009, Role of HIF-1alpha in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells, Am. J. Physiol. Lung Cell. Mol. Physiol., 297, L631, 10.1152/ajplung.90415.2008

Higuchi, 2007, Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology, Clin. Sci., 112, 417, 10.1042/CS20060342

Oppermann, 1996, Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C, J. Biol. Chem., 271, 13266, 10.1074/jbc.271.22.13266

Kim, 2005, Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling, Proc. Natl. Acad. Sci. U.S.A., 102, 1442, 10.1073/pnas.0409532102

Grobe, 2008, An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy, Physiology, 23, 187, 10.1152/physiol.00002.2008

Mueller, 2007, Exercise training and sympathetic nervous system activity: evidence for physical activity dependent neural plasticity, Clin. Exp. Pharmacol. Physiol., 34, 377, 10.1111/j.1440-1681.2007.04590.x