The cardiovascular risk profile of middle‐aged women with polycystic ovary syndrome

Clinical Endocrinology - Tập 92 Số 2 - Trang 150-158 - 2020
Cindy Meun1, Marlise N. Gunning2, Yvonne V. Louwers1, Henrike E. Peters3, Jolien W. Roos‐Hesselink4, Antoinette MaassenVanDenBrink5, Oscar L. Rueda‐Ochoa6,7, Christianne J.M. de Groot8, Cornelis B. Lambalk3, Eric Boersma4, Maryam Kavousi6, Bart C.J.M. Fauser2, Joop S.E. Laven1
1Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynaecology Erasmus University Medical Center Rotterdam The Netherlands
2Department of Reproductive Medicine & Gynecology University Medical Center Utrecht, University of Utrecht Utrecht the Netherlands
3Department of Obstetrics and Gynecology Amsterdam UMC – location VUmc Amsterdam The Netherlands
4Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands
5Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
6Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
7School of Medicine, Universidad Industrial de Santander, Bucaramanga, Colombia
8Department of Cardiology, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands

Tóm tắt

AbstractObjectivesContradictory results have been reported regarding the association between polycystic ovary syndrome (PCOS) and cardiovascular disease (CVD). We assessed the cardiometabolic phenotype and prevalence of CVD in middle‐aged women with PCOS, compared with age‐matched controls from the general population, and estimated 10‐year CVD risk and cardiovascular health score.DesignA cross‐sectional study.Participants200 women aged >45 with PCOS, and 200 age‐matched controls.MeasurementsAnthropometrics, insulin, lipid levels, prevalence of metabolic syndrome and type II diabetes. Ten‐year Framingham risk score and the cardiovascular health score were calculated, and carotid intima‐media thickness (cIMT) was measured.ResultsMean age was 50.5 years (SD = 5.5) in women with PCOS and 51.0 years (SD = 5.2) in controls. Increased waist circumference, body mass index and hypertension were more often observed in women with PCOS (P < .001). In women with PCOS, the prevalence of type II diabetes and metabolic syndrome was not significantly increased and lipid levels were not different from controls. cIMT was lower in women with PCOS (P < .001). Calculated cardiovascular health and 10‐year CVD risk were similar in women with PCOS and controls.ConclusionsMiddle‐aged women with PCOS exhibit only a moderately unfavourable cardiometabolic profile compared to age‐matched controls, even though they present with an increased BMI and waist circumference. Furthermore, we found no evidence for increased (10‐year) CVD risk or more severe atherosclerosis compared with controls from the general population. Long‐term follow‐up of women with PCOS is necessary to provide a definitive answer concerning long‐term risk for CVD.

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Clinical Endocrinology

Tập 92 Số 2

150-158

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