The bitter Asteraceae: An interesting approach to delay the metabolic syndrome progression

NFS Journal - Tập 18 - Trang 29-38 - 2020
Abdulmonem Awwad1, Patrick Poucheret1, Arezki Yanis Idres1, Luc Bidel2, Didier Tousch1
1University Montpellier, UMR 95 Qualisud, CIRAD, SupAgro Montpellier, University of Avignon, University of the Reunion, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France
2INRA, UMR AGAP, CIRAD, SupAgro, 2 Place Pierre Viala, 34060 Montpellier, France

Tài liệu tham khảo

Alberti, 2006, Metabolic syndrome—a new world-wide definition. A Consensus Statement from the International Diabetes Federation, Diabet. Med., 23, 469, 10.1111/j.1464-5491.2006.01858.x Kaur, 2014, Comprehensive review on metabolic syndrome, Cardiol. Res. Pract., 2014, 10.1155/2014/943162 Aguilar, 2015, Prevalence of the metabolic syndrome in the United States, 2003-2012, JAMA., 313, 1973, 10.1001/jama.2015.4260 Reaven, 1993, Role of insulin resistance in human disease (syndrome X): an expanded definition, Annu. Rev. Med., 44, 121, 10.1146/annurev.me.44.020193.001005 Chen, 2015, Mechanisms linking inflammation to insulin resistance, Int. J. Endocrinol., 2015, 508409, 10.1155/2015/508409 Shoelson, 2007, Obesity, inflammation, and insulin resistance, Gastroenterology., 132, 2169, 10.1053/j.gastro.2007.03.059 McArdle, 2013, Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies, Front Endocrinol (Lausanne)., 52, 1 Bastard, 2006, Recent advances in the relationship between obesity, inflammation, and insulin resistance, Eur. Cytokine Netw., 17, 4 Furukawa, 2004, Increased oxidative stress in obesity and its impact on metabolic syndrome, J. Clin. Invest., 114, 1752, 10.1172/JCI21625 Whaley-Connell, 2011, The role of oxidative stress in the metabolic syndrome, Rev. Cardiovasc. Med., 12, 21, 10.3909/ricm0555 Fabricatore, 2003, Treatment of obesity: an overview, Clinical Diabetes., 21, 67, 10.2337/diaclin.21.2.67 Beidokhti, 2017, Review of antidiabetic fruits, vegetables, beverages, oils and spices commonly consumed in the diet, J. Ethnopharmacol., 201, 26, 10.1016/j.jep.2017.02.031 Baspinar, 2017, How coffee affects metabolic syndrome and its components, Food Funct., 8, 2089, 10.1039/C7FO00388A Meng, 2013, Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review, Evid Based Complement Altern Med., 2013, 10.1155/2013/801457 Rochlani, 2017, Metabolic syndrome: pathophysiology, management, and modulation by natural compounds, Ther. Adv. Cardiovasc. Dis., 11, 215, 10.1177/1753944717711379 Cherniack, 2011, Polyphenols: planting the seeds of treatment for the metabolic syndrome, Nutrition., 27, 617, 10.1016/j.nut.2010.10.013 Williamson, 2017, The role of polyphenols in modern nutrition, Nutr. Bull., 42, 226, 10.1111/nbu.12278 Vinholes, 2015, Hydroxycinnamic acids (HCAs): Structure, biological properties and health effects, Adv Med Biol., 88 Alam, 2016, Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity, Nutr Metab (Lond), 13 Fraisse, 2011, Caffeoyl Derivatives: Major Antioxidant Compounds of Some Wild Herbs of the Asteraceae Family, Food Nutr Sci., 2, 181 Tang, 2014, Cardioprotective effect of protocatechuic acid on myocardial ischemia/reperfusion injury, J. Pharmacol. Sci., 125, 176, 10.1254/jphs.13247FP Basnet, 1996, Four di-O-caffeoyl quinic acid derivatives from propolis. Potent hepatoprotective activity in experimental liver injury models, Biol. Pharm. Bull., 19, 1479, 10.1248/bpb.19.1479 Madrigal-Santillán, 2014, Review of natural products with hepatoprotective effects, World J. Gastroenterol., 28, 14787, 10.3748/wjg.v20.i40.14787 Zhao, 2012, Antihypertensive effects and mechanisms of chlorogenic acids, Hypertens. Res., 35, 370, 10.1038/hr.2011.195 Park, 2009, The anti-oxidative and anti-inflammatory effects of caffeoyl derivatives from the roots of Aconitum koreanum R. RAYMOND, Biol. Pharm. Bull., 32, 2029, 10.1248/bpb.32.2029 Bessada, 2015, Asteraceae species with most prominent bioactivity and their potential applications: a review, Ind. Crop. Prod., 76, 604, 10.1016/j.indcrop.2015.07.073 Jung, 2006, Antihyperglycemic and antioxidant properties of Caffeic acid in db/db mice, J. Pharmacol. Exp. Ther., 318, 476, 10.1124/jpet.106.105163 Azay-Milhau, 2013, Antihyperglycemic effect of a natural chicoric acid extract of chicory (Cichorium intybus L.): a comparative in vitro study with the effects of caffeic and ferulic acids, J Ethnopharmacol., 150, 755, 10.1016/j.jep.2013.09.046 Adisakwattana, 2017, Cinnamic acid and its derivatives: mechanisms for prevention and management of diabetes and its complications, Nutrients., 9, 163, 10.3390/nu9020163 Spínola, 2017, Evaluation of Asteraceae herbal extracts in the management of diabetes and obesity. Contribution of caffeoylquinic acids on the inhibition of digestive enzymes activity and formation of advanced glycation end-products (in vitro), Phytochemistry, 143, 29, 10.1016/j.phytochem.2017.07.006 Valussi, 2012, Functional foods with digestion-enhancing properties, Int. J. Food Sci. Nutr., 63, 82, 10.3109/09637486.2011.627841 Asija, 2016, Comprehensive Review on Antihyperlipidemic Activity of Various Medicinal Plants, Int. J. Curr. Pharm. Rev. Res., 7, 407 Salaponic, 2013, Quantification of sesquiterpene lactones in Asteraceae plant extracts: evaluation of their allergic potential, Sci. Pharm., 81, 807, 10.3797/scipharm.1306-17 Elsharkawy, 2014, Anti-inflammatory and chemical Composition of two plants family Asteraceae growing in Saudi Arabia, J Chem Chem Eng., 8, 157 Behara, 2011, Pharmacological studies on artichoke leaf extract - an edible herb of Mediterranean origin, J. Pharm. Biomed. Sci., 11, 1 Jiménez-Escrig, 2003, Vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats, J. Agric. Food Chem., 51, 5540, 10.1021/jf030047e Bekheet, 2019, Biodiversity and medicinal uses of globe artichoke (Cynara scolymus L.) plant, J. Biodivers. Conserv. Bioresour. Manag., 5, 39, 10.3329/jbcbm.v5i1.42184 Ben Salem, 2017, Chemicals compositions, antioxidant and anti-inflammatory activity of Cynara scolymus leaves extracts, and analysis of major bioactive polyphenols by HPLC, Evid. Based Complement. Alternat. Med., 2017, 10.1155/2017/4951937 Hosseini, 2015, Effect of hydro alcoholic extract of artichoke on diabetes treatment and liver enzymes in diabetic adult male rats, Adv. Herb. Med., 1, 17 Egharevba, 2014, Significance of bitter leaf (Vernonia Amagdalina) in tropical diseases and beyond: a review, Malaria Chemotherapy Control & Elimination, 3, 1, 10.4172/2090-2778.1000120 Erasto, 2007, Antioxidant constituents in Vernonia amygdalina. Leaves, J Pharmaceutical Biology., 45, 195, 10.1080/13880200701213070 Erasto, 2009, Effect of leaf extracts of Vernonia amygdalina on glucose utilization in chang-liver, C2C12 muscle and 3T3-L1 cells, Pharm. Biol., 47, 175, 10.1080/13880200802436927 Ibrahim, 2001, Elemental analysis of the leaves of Vernonia amygdalina and its biological evaluation rats, Niger J Nat Prod Med., 5, 13 Ong, 2011, Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects instreptozotocin-induced diabetic rats, J. Ethnopharmacol., 133, 598, 10.1016/j.jep.2010.10.046 Al-Snafi, 2016, The constituents and pharmacology of Cnicus Benedictus. A review, Pharm. Chem. J., 3, 129 Sahan, 2013, Antioxidant properties and their bioaccessibility of Blessed Thistle under different processed treatments, FASEB Journal, 27 Tousch, 2014, Chemical analysis and antihyperglycemic activity of an original extract from burdock root (Arctium lappa), J. Agric. Food Chem., 62, 7738, 10.1021/jf500926v Lou, 2010, Antioxidant activity and chemical composition of the fractions from burdock leaves, J. Food Sci., 75, 413 Lin, 1996, Anti-inflammatory and radical scavenge effects of Arctium lappa, Am. J. Chin. Med., 24, 127, 10.1142/S0192415X96000177 Cao, 2012, Antidiabetic effect of burdock (Arctium lappa L.) root ethanolic extract on streptozotocin-induced diabetic rats, Afr. J. Biotechnol., 11, 9079 Carnat, 2004, The aromatic and polyphenolic composition of Roman camomile tea, Fitoterapia., 75, 32, 10.1016/j.fitote.2003.07.007 Srivastava, 2009, Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity, Life Sci., 85, 663, 10.1016/j.lfs.2009.09.007 Weidner, 2013, Antidiabetic effects of chamomile flowers extract in obese mice through transcriptional stimulation of nutrient sensors of the peroxisome proliferator-activated receptor (PPAR) family, PLoS One, 8, 10.1371/journal.pone.0080335 Chandra, 2016, Therapeutic potential of chicorium intybus in lifestyle disorders: a review, Asian J Pharm Clin Res., 9, 20 Street, 2013, Cichorium intybus: traditional uses, phytochemistry, pharmacology, and toxicology, Evid Based Complement Alternat Med., 2013, 579319, 10.1155/2013/579319 Pushparaj, 2007, Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats, J. Ethnopharmacol., 111, 430, 10.1016/j.jep.2006.11.028 Ghamarian, 2012, Effect of chicory seed extract on glucose tolerance test (GTT) and metabolic profile in early and late stage diabetic rats, Daru., 20, 56, 10.1186/2008-2231-20-56 Choi, 2010, Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits, Int. J. Mol. Sci., 11, 67, 10.3390/ijms11010067 Jeon, 2008, Anti-inflammatory activity of Taraxacum officinale, J Ethnopharmacol., 115, 82, 10.1016/j.jep.2007.09.006 Amin Mir, 2015, In-vitro antidiabetic studies of various extracts of Taraxacum officinale, Pharma Innov., 4, 61 Iddrisu, 2015, Anti-diabetic effect of dandelion leaves and roots in type two diabetic patients: a systematic review, Nutrition & Food Science., 45, 479, 10.1108/NFS-01-2015-0001 Clare, 2009, The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day, J. Altern. Complement. Med., 15, 929, 10.1089/acm.2008.0152 Gökbulut, 2013, Antioxidant and antimicrobial activities, and phenolic compounds of selected Inula species from Turkey, Nat Prod Commun., 8, 475 Park, 2013, Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice, Food Chem. Toxicol., 55, 386, 10.1016/j.fct.2012.12.027 Marles, 1995, Antidiabetic plants and their active constituents, Phytomedicine., 2, 137, 10.1016/S0944-7113(11)80059-0 Antunes Viegas, 2014, Helichrysum italicum: from traditional use to scientific data, J. Ethnopharmacol., 151, 54, 10.1016/j.jep.2013.11.005 De la Garza, 2013, Helichrysum and grapefruit extracts inhibit carbohydrate digestion and absorption, improving postprandial glucose levels and hyperinsulinemia in rats, J Agric Food Chem., 61, 12012, 10.1021/jf4021569 Sala, 2002, Anti-inflammatory and antioxidant properties of Helichrysum italicum, J. Pharm. Pharmacol., 54, 365, 10.1211/0022357021778600 MacKaya, 2013, Cytotoxic activity of extracts from Hypochaeris radicata, Toxicon X., 70, 194, 10.1016/j.toxicon.2013.04.023 El-Hage, 2019, Pasture-associated stringhalt: contemporary appraisal of an enigmatic syndrome, Equine Vet Educ., 31, 154, 10.1111/eve.12751 Jamuna, 2015, Confertin and scopoletin from leaf and root extracts of Hypochaeris radicata have anti-inflammatory and antioxidant activities, Ind. Crop. Prod., 70, 221, 10.1016/j.indcrop.2015.03.039 Al-Snafi, 2017, Chemical constituents, pharmacological and therapeutic effects of Eupatorium Cannabinum- a review, Indo Am. J. Pharma. Sci., 4, 160 Gray, 1998, Actions of the traditional anti-diabetic plant, agrimony eupatoria (agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion, Br. J. Nutr., 80, 109, 10.1017/S0007114598001834 Ivanova, 2013, Agrimonia eupatoria tea consumption in relation to markers of inflammation, oxidative status and lipid metabolism in healthy subjects, Arch Physiol Biochem., 119, 32, 10.3109/13813455.2012.729844 Fu, 2002, Pyrrolizidine alkaloids -tumorigenic components in Chinese herbal medicines and dietary supplements, J. Food Drug Anal., 10, 198 Janbaz, 2013, Pharmacological effects of Lactuca serriola L, in experimental model of gastrointestinal, respiratory, and vascular ailments, Evid Based Complement Alternat Med., 2013, 10.1155/2013/304394 Kim, 2001, Antioxidative components from the aerial parts of Lactuca scariola L, Arch Pharm Res., 24, 427, 10.1007/BF02975189 Llorach, 2004, Lettuce and chicory Byproducts as a source of antioxidant phenolic extracts, J. Agric. Food Chem., 52, 5109, 10.1021/jf040055a Chadchan, 2016, Anti-diabetic effects of aqueous prickly lettuce (Lactuca scariola Linn.) leaves extract in alloxan-induced male diabetic rats treated with nickel (II), J Basic Clin Physiol Pharmacol., 27, 49, 10.1515/jbcpp-2015-0038 Jacobs, 2002, Milk thistle for the treatment of liver disease: a systematic review and meta-analysis, Am. J. Med., 113, 506, 10.1016/S0002-9343(02)01244-5 Karimi, 2011, "Silymarin", a promising pharmacological agent for treatment of diseases, Iran J Basic Med Sci., 14, 308 Kazazis, 2014, The therapeutic potential of milk thistle in diabetes, Rev. Diabet. Stud., 11, 167, 10.1900/RDS.2014.11.167 Petrovic, 1999, Taraxasterol derivate and compounds from Hieracium gymnocephalum, Phytochemistry., 50, 293, 10.1016/S0031-9422(98)00536-6 Stanojević, 2009, Antioxidant activity and Total phenolic and flavonoid contents of Hieracium pilosella L, Extracts. Sensors (Basel)., 9, 5702, 10.3390/s90705702 Stanojevic, 2008, Anti-oxidative and antimicrobial activities of Hieracium pilosella L. extracts, J Serb Chem Soc., 73, 531, 10.2298/JSC0805531S Mishima, 2004, Antioxidant and immuno-enhancing effects of Echinacea purpurea, Biol. Pharm. Bull., 27, 1004, 10.1248/bpb.27.1004 Christensen, 2010, Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.), J Ethnopharmacol., 132, 127, 10.1016/j.jep.2010.07.054 Zhu, 2015, Cichoric acid reverses insulin resistance and suppresses inflammatory responses in the glucosamine-induced HepG2 cells, J. Agric. Food Chem., 63, 10903, 10.1021/acs.jafc.5b04533 Tahraoni, 2007, Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Marocco (Errachidia province), J. Ethnopharmacol., 110, 105, 10.1016/j.jep.2006.09.011 Akrout, 2012, Chemical composition and antioxidant activity of aqueous extracts of some wild medicinal plant in southern Tunisia, International Journal of Life Science and Medical Research., 2, 1, 10.5963/LSMR0201001 Mohamed, 2010, Chemical constituents and biological activities of Artemisia herba-alba, Rec. Nat. Prod., 4, 1 Awad, 2012, Hypoglycemic activity of artemisia herba-alba (Asso.) used in egyptian traditional medicine as hypoglycemic remedy, J. Appl. Pharm. Sci., 3, 30 Abid, 2007, Artemisia herba-alba Asso (Asteraceae) has equivalent effects to green and black tea decoctions on antioxidant process and some metabolic parameters in rats, Ann. Nutr. Metab., 51, 216, 10.1159/000104140 Kordali, 2005, J. Agric. Food Chem., 53, 9452, 10.1021/jf0516538 Eidi, 2016, Antinociceptive and anti-inflammatory effects of the aerial parts of Artemisia dracunculus in mice, Pharm. Biol., 54, 549, 10.3109/13880209.2015.1056312 Ribnicky, 2006, Antihyperglycemic activity of Tarralin, an ethanolic extract of Artemisia dracunculus L, Phytomedicine., 13, 550, 10.1016/j.phymed.2005.09.007 Wanga, 2008, Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture, Metabolism, 57, S58, 10.1016/j.metabol.2008.04.003 Graf, 2010, Plant-derived therapeutics for the treatment of metabolic syndrome, Curr. Opin. Investig. Drugs, 11, 1107 Masoudi, 2017, A review study of ethnopharmacology, phytochemistry and anti-inflammatory, antioxidant and anti-microbial effect of Artemisia absinthium, Pharm. Lett., 9, 155 Daradka, 2014, Antidiabetic effect of Artemisia absinthium extracts on alloxan-induced diabetic rats, Comp Clin Path., 6, 1733, 10.1007/s00580-014-1963-1 Chadwick, 2013, Sesquiterpenoids lactones: benefits to plants and people, Int. J. Mol. Sci., 14, 12780, 10.3390/ijms140612780 Giordano, 1990, The gastric cytoprotective effect of several sesquiterpene lactones, J. Nat. Prod., 53, 803, 10.1021/np50070a004 Ramana, 2004, Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase, Diabetes, 53, 2910, 10.2337/diabetes.53.11.2910 Siedle, 2004, Quantitative structure-activity relationship of sesquiterpene lactone as inhibitors of the transcription factor NF-kB, J. Med. Chem., 47, 6042, 10.1021/jm049937r Jia, 2013, Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1expression in rat mesangial cells, Molecules, 18, 13061, 10.3390/molecules181013061 Ripoll, 2007, Anti-inflammatory effects of a sesquiterpene lactone extract from chicory (Cichorium intybus L.) roots, Nat Prod Commun., 2, 717 Pandey, 2009, Plant polyphenols as dietary antioxidants in human health and disease, Oxidative Med. Cell. Longev., 2, 270, 10.4161/oxim.2.5.9498 Jaiswal, 2011, Determination of the hydroxycinnamate profile of 12 members of the Asteraceae family, Phytochemistry, 72, 781, 10.1016/j.phytochem.2011.02.027 Qing, 2010, Rapid determination of caffeoylquinic acid derivatives in Cynara scolymus L. by ultrafast liquid chromatography/tandem mass spectrometry based on a fused core C18 column, J Sep Sci., 33, 3152, 10.1002/jssc.201000397 Johnson, 2011, Identification of the phenolic components of Vernonia amygdalina and Russelia equisetiformis, J. Nat. Prod., 4, 57 Singh, 2011, Manoj Kumar Srivastava, Chamomile (Matricaria chamomilla L.): An overview, Pharmacogn Rev., 5, 82, 10.4103/0973-7847.79103 Haghi, 2014, Analysis of phenolic compounds in Matricaria chamomilla and its extracts by UPLC-UV, Res Pharm Sci., 9, 31 Ferrare, 2018, Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect, Journal of Ethnopharmacology, 215, 241, 10.1016/j.jep.2017.12.035 Lee, 2013, Chicoric acid: chemistry, distribution, and production, Front Chem., 1 Schütz, 2005, Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry, Rapid Commun. Mass Spectrom., 19, 179, 10.1002/rcm.1767 Scognamiglio, 2015, Chemical composition and seasonality of aromatic mediterranean plant species by NMR-based, metabolomics hindawi publishing corporation, Journal of Analytical Methods in Chemistry, 258570 Zapesochnaya, 1990, Phenolic compounds of Helichrysum italicum, Chem. Nat. Compd., 26, 342, 10.1007/BF00597869 Og-Yim, 2005, Composition of phenolic compounds in Hypochaeris radica L. Extracts and their Allelopathic Effects on Gramineous Forage Crops, Korean Journal of Environmental Agriculture, 24, 391, 10.5338/KJEA.2005.24.4.391 Ionita, 2013, Pharmacological activity of an Eupatorium cannabinum L. extract, Rom. Biotechnol. Lett., 18, 8779 Meddeb, 2017, Tunisian Milk thistle: an investigation of the chemical Composition and the characterization of its cold-pressed seed oils, Int. J. Mol. Sci., 18, 2582, 10.3390/ijms18122582 Borisova-Jan, 2017, Liquid chromatographic method for the determination of caffeoylquinic acid derivates inHieracium pilosella L, Phytochem. Anal., 28, 550, 10.1002/pca.2704 Erenler, 2015, Chemical constituents, quantitative analysis and antioxidant activities of Echinacea purpurea (L.) Moench and Echinacea pallida (Nutt.) Nutt, Food Biochem, 39, 622, 10.1111/jfbc.12168 Seddik, 2010, Antioxidant and antibacterial activities of extracts from Artemisia herba albaAsso. leaves and some phenoliccompounds, J. Med. Plant Res., 4, 1273 Souhila, 2019, Identification and quantification of phenolic compounds of Artemisia herba-alba at three harvest time by HPLC–ESI–Q-TOF–MS, Int. J. Food Prop., 22, 843, 10.1080/10942912.2019.1614051 Obolskiy, 2011, Nikolay Glotov, M. Heinrich, Artemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical Composition, pharmacology, and safety, J. Agric. Food Chem., 59, 11367, 10.1021/jf202277w Msaada, 2015, Chemical composition and antioxidant and antimicrobial activities of wormwood (Artemisia absinthium L.) essential oils and phenolics, J Chem, 2015, 10.1155/2015/804658 Ivanescu, 2016, HPLC analysis of phenolic compounds from Artemisia species, Eur. Chem. Bull., 5, 119 Clifford, 2000, Chlorogenic acids and other cinnamates-nature, occurrence, dietary burden, absorption and metabolism, J. Sci. Food Agric., 80, 1033, 10.1002/(SICI)1097-0010(20000515)80:7<1033::AID-JSFA595>3.0.CO;2-T Bocco, 2016, Combinated treatment with caffeic and ferulic acid rom Baccharis uncinella C. DC. (Asteraceae) protect against metabolic syndrome in mice, Braz J Med Res, 49, 10.1590/1414-431X20155003 Narasimhan, 2015, Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat, Appl Physiol Nutr Metab., 40, 769, 10.1139/apnm-2015-0002 Casanova, 2014, Identification of chicoric acid as a hypoglycemic agent from Ocimum gratissimum leaf extract in a biomonitoring in vivo study, Fitoterapia, 93, 132, 10.1016/j.fitote.2013.12.024 De Oliveira Silva, 2017, Ferulic acid and naturally occurring compounds bearing a Feruloyl moiety: a review on their structures, occurrence, and potential health benefits, Compr. Rev. Food Sci. Food Saf., 16, 580, 10.1111/1541-4337.12266 Rice Evans, 1996, Structure-antioxidant activity relationships of flavonoids and phenolic acids, Free Radical Bio. Med., 20, 933, 10.1016/0891-5849(95)02227-9 Schlernitzauer, 2013, Chicoric acid is an antioxidant molecule that stimulates AMP kinase pathway in L6 myotubes and extends lifespan in Caenorhabditis elegans, PLoS ONE, 8, 10.1371/journal.pone.0078788 Olayinka, 2017, Ameliorative effect of caffeic acid on capecitabine-Induced hepatic and renal dysfunction: Involvement of the antioxidant defence System, Medicines (Basel), 4 Yilmaz, 2004, Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver, J. Biochem. Mol. Toxicol., 18, 234, 10.1002/jbt.20028 Xi, 2017, Effects of chlorogenic acid on capacity of free radicals scavenging and proteomic changes in postharvest fruit of nectarine, PLoS ONE, 12, 10.1371/journal.pone.0182494 Zhang, 2014, Caffeic acid reduces cutaneous tumor necrosis factor alpha (TNF-α), IL-6 and IL-1β levels and ameliorates skin Edema in acute and chronic model of cutaneous inflammation in mice, Biol. Pharm. Bull., 37, 347, 10.1248/bpb.b13-00459 Hwang, 2014, Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells, Inflamm. Res., 63, 81, 10.1007/s00011-013-0674-4 Bezerra, 2012, Caffeic acid phenethyl ester reduces the activation of the nuclear factor κB pathway by high-fat diet-induced obesity in mice, Metab. Clin. Exp., 61, 1606, 10.1016/j.metabol.2012.04.006 Liu, 2017, Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB, FASEB J., 31, 1494, 10.1096/fj.201601071R Bermúdez, 2010, PPAR-gamma agonists and their role in type 2 diabetes mellitus management, Am. J. Ther., 17, 274, 10.1097/MJT.0b013e3181c08081 Kim, 2013, PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells, PLoS ONE, 8, 10.1371/journal.pone.0050128 Lee, 2007, CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells, Biochem. Biophys. Res. Commun., 361, 854, 10.1016/j.bbrc.2007.07.068 Tousch, 2008, Chicoric acid, a new compound able to enhance insulin release and glucose uptake, Biochem. Biophys. Res. Commun., 377, 131, 10.1016/j.bbrc.2008.09.088 Hemmerle, 1997, Chlorogenic acid and synthetic chlorogenic acid derivatives: novel 531 inhibitors of hepatic glucose-6-phosphate translocase, J. Med. Chem., 40, 137, 10.1021/jm9607360 Ong, 2013, Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation, Biochem. Pharmacol., 85, 1341, 10.1016/j.bcp.2013.02.008 Baskaran, 2012, Molecular dynamics approach to probe the allosteric inhibition of PTP1B by chlorogenic and cichoric acid, J. Chem. Inf. Model., 52, 2004, 10.1021/ci200581g Kenner, 1996, Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling, Biol. Chem., 271, 19810, 10.1074/jbc.271.33.19810 Koren, 2007, Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus, Best Pract. Res. Clin. Endocrinol. Metab., 21, 621, 10.1016/j.beem.2007.08.004 Wirngo, 2016, The physiological effects of dandelion (Taraxacum Officinale) in type 2 diabetes, Rev. Diabet. Stud., 13, 113, 10.1900/RDS.2016.13.113