The bidirectional relationship between host physiology and microbiota and health benefits of probiotics: A review

Abrahamsson, 2007, Probiotics in the prevention of IgE-associated eczema: A double blind randomised placebo-controlled trial, The Journal of Allergy and Clinical Immunology, 119, 10.1016/j.jaci.2006.12.298 Anker, 2018, Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy, Nature Communications, 9, 10.1038/s41467-018-03900-x Ardeshir, 2014, Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems, Science Translational Medicine, 6, 252ra120, 10.1126/scitranslmed.3008791 Arrieta, 2015, Early infancy microbial and metabolic alterations affect risk of childhood asthma, Science Translational Medicine, 7, 10.1126/scitranslmed.aab2271 Atarashi, 2017, Ectopic colonization of oral bacteria in the intestine drives th1 cell induction and inflammation, Science, 358, 359, 10.1126/science.aan4526 Ayeni, 2018, Infant and adult gut microbiome and metabolome in rural Bassa and urban settlers from Nigeria, Cell Reports, 23, 3056, 10.1016/j.celrep.2018.05.018 Bäckhed, 2015, Dynamics and stabilization of the human gut microbiome during the first year of life, Cell Host & Microbe, 17, 690, 10.1016/j.chom.2015.04.004 Badet, 2008, Ecology of lactobacilli in the oral cavity: A review of literature, The Open Microbiology Journal, 2, 38, 10.2174/1874285800802010038 Barbosa-Cesnik, 2003, Lactation mastitis, Jama, 289, 1609, 10.1001/jama.289.13.1609 Bertuccini, 2018, Lactobacilli and lactoferrin: Biotherapeutic effects for vaginal health, Journal of Functional Foods, 45, 86, 10.1016/j.jff.2018.03.033 Bhattacharjee, 2013, Alzheimer's disease and the microbiome, Frontiers in Cellular Neuroscience, 7, 153 Bieber, 2008, Atopic dermatitis, New England Journal of Medicine, 358, 1483, 10.1056/NEJMra074081 Bongaerts, 2016, A reassessment of the propatria study and its implications for probiotic therapy, Nature Biotechnology, 34, 55, 10.1038/nbt.3436 Boutagy, 2016, Metabolic endotoxemia with obesity: Is it real and is it relevant?, Biochimie, 124, 11, 10.1016/j.biochi.2015.06.020 Brandwein, 2016, Microbial biofilms and the human skin microbiome, Npj Biofilms & Microbiomes, 2, 10.1038/s41522-016-0004-z Bravo, 2011, Ingestion of lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve, Proceedings of the National Academy of Sciences of the United States of America, 108, 16050, 10.1073/pnas.1102999108 Brinig, 2003, Prevalence of bacteria of division tm7 in human subgingival plaque and their association with disease, Applied and Environmental Microbiology, 69, 1687, 10.1128/AEM.69.3.1687-1694.2003 Bruno, 2015, Transcriptomic analysis of vulvovaginal candidiasis identifies a role for the nlrp3 inflammasome, Mbio, 6, 10.1128/mBio.00182-15 Carvalho, 2012, Transient inability to manage proteobacteria promotes chronic gut inflammation in tlr5-deficient mice, Cell Host & Microbe, 12, 139, 10.1016/j.chom.2012.07.004 Cassone, 2016, Experimental models of vaginal candidiasis and their relevance to human candidiasis, Infection and Immunity, 84, 10.1128/IAI.01544-15 Cervantes-Barragan, 2017, Lactobacillus reuteri induces gut intraepithelial cd4+cd8αα+ t cells, Science, 357, 806, 10.1126/science.aah5825 Chambers, 2015, Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults, Gut, 64, 1744, 10.1136/gutjnl-2014-307913 Chassaing, 2015, Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome, Nature, 519, 92, 10.1038/nature14232 Chassaing, 2014, Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice, Gastroenterology, 147, 1363, 10.1053/j.gastro.2014.08.033 Cheng, 2013, Regulation of toll-like receptor signaling pathways in innate immune responses, Annals of the New York Academy of Sciences, 1283, 67, 10.1111/j.1749-6632.2012.06786.x Chevalier, 2015, Gut microbiota orchestrates energy homeostasis during cold, Cell, 163, 1360, 10.1016/j.cell.2015.11.004 Collins, 2012, The interplay between the intestinal microbiota and the brain, Nature Reviews Microbiology, 10, 735, 10.1038/nrmicro2876 Costa, 2006, Health-related quality of life in postpartum depressed women, Archives Womens Mental Health, 9, 95, 10.1007/s00737-005-0108-6 Costeloe, 2016, Bifidobacterium breve bbg-001 in very preterm infants: A randomised controlled phase 3 trial, Lancet, 387, 649, 10.1016/S0140-6736(15)01027-2 Cowan, 2016 David, 2014, Diet rapidly and reproducibly alters the human gut microbiome, Nature, 505, 559, 10.1038/nature12820 Dawson, 2016, The importance of diet and gut health to the treatment and prevention of mental disorders, International Review of Neurobiology, 131, 325, 10.1016/bs.irn.2016.08.009 De Vadder, 2014, Microbiota-generated metabolites promote metabolic benefits via gutbrain neural circuits, Cell, 156, 84, 10.1016/j.cell.2013.12.016 De, 2017, Metformin is associated with higher relative abundance of mucin-degrading akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut, Diabetes Care, 40, 54, 10.2337/dc16-1324 Desantis, 2016, Cancer statistics for African Americans, 2016: Progress and opportunities in reducing racial disparities, Ca - a Cancer Journal for Clinicians, 66, 290, 10.3322/caac.21340 Dinan, 2015, The impact of gut microbiota on brain and behaviour: Implications for psychiatry, Current Opinion in Clinical Nutrition and Metabolic Care, 18, 552, 10.1097/MCO.0000000000000221 Dominguez-Bello, 2010, Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats, Proceedings of the National Academy of Sciences of the United States of America, 107, 11971, 10.1073/pnas.1002601107 Duncan, 2002, Growth requirements and fermentation products of fusobacterium prausnitzii, and a proposal to reclassify it as faecalibacterium prausnitzii gen. nov., comb. nov, International Journal of Systematic and Evolutionary Microbiology, 52, 2141 Eckel, 2005, The metabolic syndrome, Lancet, 365, 560, 10.1016/S0140-6736(05)66378-7 Everard, 2013, Cross-talk between akkermansia muciniphila and intestinal epithelium controls diet-induced obesity, Proceedings of the National Academy of Sciences of the United States of America, 110, 9066, 10.1073/pnas.1219451110 Ferreyra, 2014, Gut microbiota-produced succinate promotes c. difficile infection after antibiotic treatment or motility disturbance, Cell Host & Microbe, 16, 770, 10.1016/j.chom.2014.11.003 Floresmireles, 2015, Urinary tract infections: Epidemiology, mechanisms of infection and treatment options, Nature Reviews Microbiology, 13, 269, 10.1038/nrmicro3432 Fujimura, 2016, Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation, Nature Medicine, 22, 1187, 10.1038/nm.4176 García-Rodríguez, 2002, Dynamics of nasopharyngeal colonization by potential respiratory pathogens, Journal of Antimicrobial Chemotherapy, 50, 59, 10.1093/jac/dkf506 Gareau, 2007, Probiotic treatment of rat pups normalizes corticosterone release and ameliorates colonic dysfunction induced by maternal separation, Gut, 56, 1522, 10.1136/gut.2006.117176 Gebhardt, 2008, Probiotic prophylaxis in patients with predicted severe acute pancreatitis: A randomised, double-blind, placebo-controlled trial and informed consent procedure], Lancet, 152, 1591 Geller, 2017, Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine, Science, 357, 1156, 10.1126/science.aah5043 Gevers, 2014, The treatment-naive microbiome in new-onset Crohn's disease, Cell Host & Microbe, 15, 382, 10.1016/j.chom.2014.02.005 Grice, 2010, Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response, Vol. 107, 14799 Haan, 2006, Therapy insight: Type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease, Nature Clinical Practice Neurology, 2, 159, 10.1038/ncpneuro0124 Hamer, 2008, Review article: The role of butyrate on colonic function, Alimentary Pharmacology and Therapeutics, 27, 104, 10.1111/j.1365-2036.2007.03562.x Harach, 2017, Erratum: Reduction of abeta amyloid pathology in appps1 transgenic mice in the absence of gut microbiota, Scientific Reports, 7, 41802, 10.1038/srep41802 Heo, 2016, Gut microbiota modulated by probiotics and garcinia cambogia extract correlate with weight gain and adipocyte sizes in high fat-fed mice, Scientific Reports, 6, 33566, 10.1038/srep33566 Hermanussen, 2006, Obesity, voracity, and short stature: The impact of glutamate on the regulation of appetite, European Journal of Clinical Nutrition, 60, 25, 10.1038/sj.ejcn.1602263 Hill-Burns, 2017, Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome, Movement Disorders, 32, 739, 10.1002/mds.26942 Hill, 2014, Expert consensus document: The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic, Nature Reviews Gastroenterology & Hepatology, 11, 506, 10.1038/nrgastro.2014.66 Homayouni, 2014, Effects of probiotics on the recurrence of bacterial vaginosis: A review, Journal of Lower Genital Tract Disease, 18, 79, 10.1097/LGT.0b013e31829156ec Hooper, 2012, Interactions between the microbiota and the immune system, Science, 336, 1268, 10.1126/science.1223490 Hooper, 2001, Molecular analysis of commensal host-microbial relationships in the intestine, Science, 291, 881, 10.1126/science.291.5505.881 Ibarra, 2012, Optimization and shelf life of a low-lactose yogurt with lactobacillus rhamnosus hn001, Journal of Dairy Science, 95, 3536, 10.3168/jds.2011-5050 Ivanov, 2009, Induction of intestinal th17 cells by segmented filamentous bacteria, Cell, 139, 485, 10.1016/j.cell.2009.09.033 Jernberg, 2007, Long-term ecological impacts of antibiotic administration on the human intestinal microbiota, The ISME Journal, 7, 56, 10.1038/ismej.2007.3 Kenyon, 2010, The genetics of ageing, Nature, 464, 504, 10.1038/nature08980 Kernbauer, 2014, An enteric virus can replace the beneficial function of commensal bacteria, Nature, 516, 94, 10.1038/nature13960 Kinnebrew, 2012, Interleukin 23 production by intestinal cd103cd11b dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense, Immunity, 36, 276, 10.1016/j.immuni.2011.12.011 Konikoff, 2016, Oscillospira: A central, enigmatic component of the human gut microbiota, Trends in Microbiology, 24, 523, 10.1016/j.tim.2016.02.015 Kumar, 2006, Changes in periodontal health status are associated with bacterial community shifts as assessed by quantitative 16s cloning and sequencing, Journal of Clinical Microbiology, 44, 3665, 10.1128/JCM.00317-06 Leone, 2014, Diet, gut microbes, and genetics in immune function: Can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases?, Current Opinion in Immunology, 31, 16, 10.1016/j.coi.2014.08.004 Leone, 2015, Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism, Cell Host & Microbe, 17, 681, 10.1016/j.chom.2015.03.006 Ley, 2006, Microbial ecology: Human gut microbes associated with obesity, Nature, 444, 1022, 10.1038/4441022a Ley, 2008, Worlds within worlds: Evolution of the vertebrate gut microbiota, Nature Reviews Microbiology, 6, 776, 10.1038/nrmicro1978 Ling, 2011, Diversity of cervicovaginal microbiota associated with female lower genital tract infections, Microbial Ecology, 61, 704, 10.1007/s00248-011-9813-z Lin, 2007, Role of bacterial pathogens in atopic dermatitis, Clinical Reviews in Allergy and Immunology, 33, 167, 10.1007/s12016-007-0044-5 Liu, 2017, Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention, Nature Medicine, 23, 859, 10.1038/nm.4358 Liu, 2016, Abrupt suspension of probiotics administration may increase host pathogen susceptibility by inducing gut dysbiosis, Scientific Reports, 6, 23214, 10.1038/srep23214 Lópezlópez, 2017, Health-associated niche inhabitants as oral probiotics: The case of streptococcus dentisani, Frontiers in Microbiology, 8 Lozupone, 2013, Alterations in the gut microbiota associated with hiv-1 infection, Cell Host & Microbe, 14, 329, 10.1016/j.chom.2013.08.006 Lozupone, 2012, Diversity, stability and resilience of the human gut microbiota, Nature, 489, 220, 10.1038/nature11550 Madhur, 2010, Interleukin 17 promotes angiotensin ii-induced hypertension and vascular dysfunction, Hypertension, 55, 500, 10.1161/HYPERTENSIONAHA.109.145094 Magnusson, 2013, A diabetes-predictive amino acid score and future cardiovascular disease, European Heart Journal, 34, 1982, 10.1093/eurheartj/ehs424 Ma, 2018, Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells, Science, 360, 10.1126/science.aan5931 Makino, 2013, Mother-to-infant transmission of intestinal bifidobacterial strains has an impact on the early development of vaginally delivered infant's microbiota, PLoS One, 8, 10.1371/journal.pone.0078331 Mantzourani, 2009, Association between bifidobacteriaceae, and the clinical severity of root caries lesions, Oral Microbiology and Immunology, 24, 32, 10.1111/j.1399-302X.2008.00470.x Manzel, 2014, Role of "western diet" in inflammatory autoimmune diseases, Current Allergy and Asthma Reports, 14, 404, 10.1007/s11882-013-0404-6 Marlowe, 2010, The Hadza: Hunter-gatherers of Tanzania, Origins of human behavior and culture, 3 Messaoudi, 2011, Assessment of psychotropic-like properties of a probiotic formulation (lactobacillus helveticus r0052 and bifidobacterium longum r0175) in rats and human subjects, British Journal of Nutrition, 105, 755, 10.1017/S0007114510004319 Minot, 1907, Vol. 31, 133 Morin, 2015, Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model, Arthritis Research and Therapy, 17, 142, 10.1186/s13075-015-0653-y Mucida, 2013, Transcriptional reprogramming of mature cd4+ helper t cells generates distinct mhc class ii–restricted cytotoxic t lymphocytes, Nature Immunology, 14, 281, 10.1038/ni.2523 Nakamura, 2013, Staphylococcus [dgr]-toxin induces allergic skin disease by activating mast cells, Nature, 503, 397, 10.1038/nature12655 Nicholson, 2012, Host-gut microbiota metabolic interactions, Science, 336, 1262, 10.1126/science.1223813 Norlander, 2016, Interleukin-17a regulates renal sodium transporters and renal injury in angiotensin ii-induced hypertension, Hypertension, 68, 167, 10.1161/HYPERTENSIONAHA.116.07493 O'Toole, 2017, Next-generation probiotics: The spectrum from probiotics to live biotherapeutics, Nature Microbiology, 2, 17057, 10.1038/nmicrobiol.2017.57 Oláh, 2002, Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis, British Journal of Surgery, 89, 1103, 10.1046/j.1365-2168.2002.02189.x Olney, 1969, Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate, Science, 164, 719, 10.1126/science.164.3880.719 Oshima, 2013, Treg induction by a rationally selected mixture of clostridia strains from the human microbiota, Nature, 500, 232, 10.1038/nature12331 Otto, 2009, Staphylococcus epidermidis--the 'accidental' pathogen, Nature Reviews Microbiology, 7, 555, 10.1038/nrmicro2182 Oza, 2015, Neonatal cause-of-death estimates for the early and late neonatal periods for 194 countries: 2000–2013, Bulletin of the World Health Organization, 93, 19, 10.2471/BLT.14.139790 Panigrahi, 2017, A randomized synbiotic trial to prevent sepsis among infants in rural India, Nature, 548, 407, 10.1038/nature23480 Perez, 2007, Bacterial imprinting of the neonatal immune system: Lessons from maternal cells?, Pediatrics, 119, e724, 10.1542/peds.2006-1649 Petrova, 2015, Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health, Frontiers in Physiology, 6, 81, 10.3389/fphys.2015.00081 Pickard, 2014, Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness, Nature, 514, 638, 10.1038/nature13823 Pimplikar, 2014, Neuroinflammation in Alzheimer's disease: From pathogenesis to a therapeutic target, Journal of Clinical Immunology, 34, 64, 10.1007/s10875-014-0032-5 Plaza-Diaz, 2014, Effects of lactobacillus paracasei cncm i-4034, bifidobacterium breve cncm i-4035 and lactobacillus rhamnosus cncm i-4036 on hepatic steatosis in zucker rats, PLoS One, 9, 10.1371/journal.pone.0098401 Prescott, 2007, Probiotics for the prevention or treatment of allergic diseases, The Journal of Allergy and Clinical Immunology, 120, 255, 10.1016/j.jaci.2007.04.027 Qian, 2018, Detection of microbial 16s rRNA gene in the blood of patients with Parkinson ’s disease, Frontiers in Aging Neuroscience, 10, 10.3389/fnagi.2018.00156 Qin, 2014, Alterations of the human gut microbiome in liver cirrhosis, Nature, 513, 59, 10.1038/nature13568 Reyes, 2014, Probiotic effects on late-onset sepsis in very preterm infants, Revista Chilena De Infectologia Organo Oficial De La Sociedad Chilena De Infectologia, 31, 224, 10.4067/S0716-10182014000200017 Ridlon, 2006, Bile salt biotransformations by human intestinal bacteria, Journal of Lipid Research, 47, 241, 10.1194/jlr.R500013-JLR200 Ringel-Kulka, 2011, Probiotic bacteria lactobacillus acidophilus ncfm and bifidobacterium lactis bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: A double-blind study, Journal of Clinical Gastroenterology, 45 Rivera, 2007, Toll-like receptor-4 signaling and kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis, Journal of Hepatology, 47, 571, 10.1016/j.jhep.2007.04.019 Rizzo, 2015, Lactobacillus crispatus mediates anti-inflammatory cytokine interleukin-10 induction in response to chlamydia trachomatis infection in vitro, International Journal of Medical Microbiology, 305, 815, 10.1016/j.ijmm.2015.07.005 Roerig, 2010, Laxative abuse: Epidemiology, diagnosis and management, Drugs, 70, 1487, 10.2165/11898640-000000000-00000 Roselli, 2006, Probiotic bacteria bifidobacterium animalis mb5 and lactobacillus rhamnosus gg protect intestinal caco-2 cells from the inflammation-associated response induced by enterotoxigenic escherichia coli k88, British Journal of Nutrition, 95, 1177, 10.1079/BJN20051681 Round, 2010, Inducible foxp3+ regulatory t-cell development by a commensal bacterium of the intestinal microbiota, Proceedings of the National Academy of Sciences of the United States of America, 107, 12204, 10.1073/pnas.0909122107 Sakamoto, 2007, Barnesiella viscericola gen. nov. sp. nov. a novel member of the family porphyromonadaceae isolated from chicken caecum, International Journal of Systematic and Evolutionary Microbiology, 57, 342, 10.1099/ijs.0.64709-0 Salonen, 2014, Impact of diet on human intestinal microbiota and health, Annual review Food Science and Technology, 5, 239, 10.1146/annurev-food-030212-182554 Sauracalixto, 2010, Proanthocyanidin metabolites associated with dietary fibre from in vitro colonic fermentation and proanthocyanidin metabolites in human plasma, Molecular Nutrition & Food Research, 54, 939, 10.1002/mnfr.200900276 Schneider, 2000, Anaerobic degradation of flavonoids by eubacterium ramulus, Archives of Microbiology, 173, 71, 10.1007/s002030050010 Shin, 2014, An increase in the akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice, Gut, 63, 727, 10.1136/gutjnl-2012-303839 Simpson, 2010, Beyond atopy multiple patterns of sensitization in relation to asthma in a birth cohort study, American Journal of Respiratory and Critical Care Medicine, 181, 1200, 10.1164/rccm.200907-1101OC Sinha, 2015, Role of probiotics vsl#3 in prevention of suspected sepsis in low birthweight infants in India: A randomized controlled trial, BMJ Open, 5, 10.1136/bmjopen-2014-006564 Slykerman, 2017, Effect of lactobacillus rhamnosushn001 in pregnancy on postpartum symptoms of depression and anxiety: A randomized double-blind placebo-controlled trial, Ebiomedicine, 24, 159, 10.1016/j.ebiom.2017.09.013 Sokol, 2008, Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of crohn disease patient, Proceedings of the National Academy of Sciences of the United States of America, 105, 16731, 10.1073/pnas.0804812105 Sonnenburg, 2014, Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates, Cell Metabolism, 20, 779, 10.1016/j.cmet.2014.07.003 Staley, 2017, Interaction of gut microbiota with bile acid metabolism and its influence on disease states, Applied Microbiology and Biotechnology, 101, 47, 10.1007/s00253-016-8006-6 Steed, 2017, The microbial metabolite desaminotyrosine protects from influenza through type I interferon, Science, 357, 498, 10.1126/science.aam5336 Suez, 2014, Artificial sweeteners induce glucose intolerance by altering the gut microbiota, Nature, 70, 181, 10.1038/nature13793 Sujino, 2016, Tissue adaptation of regulatory and intraepithelial CD4(+) cells controls gut inflammation, Science, 352, 1581, 10.1126/science.aaf3892 Taylor, 2007, Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial, The Journal of Allergy and Clinical Immunology, 119, 184, 10.1016/j.jaci.2006.08.036 Thaiss, 2014, Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis, Cell, 159, 514, 10.1016/j.cell.2014.09.048 Theriot, 2015, Antibiotic-induced alterations of the gut microbiota alter secondary bile acid production and allow for clostridium difficile spore germination and outgrowth in the large intestine, mSphere, 1, 1 Thorburn, 2014, Diet, metabolites, and "western-lifestyle" inflammatory diseases, Immunity, 40, 833, 10.1016/j.immuni.2014.05.014 Tropini, 2018, Transient osmotic perturbation causes long-term alteration to the gut microbiota, Cell, 173, 1742, 10.1016/j.cell.2018.05.008 Tumeh, 2014, Pd-1 blockade induces responses by inhibiting adaptive immune resistance, Nature, 515, 568, 10.1038/nature13954 Veiga, 2010, Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes, Vol. 107, 18132 Vieira Colombo, 2016, Periodontal-disease-associated biofilm: A reservoir for pathogens of medical importance, Microbial Pathogenesis, 94, 27, 10.1016/j.micpath.2015.09.009 Wang, 2017, The intestinal microbiota regulates body composition through nfil3 and the circadian clock, Science, 357, 912, 10.1126/science.aan0677 Wang, 2011, Metabolite profiles and the risk of developing diabetes, Nature Medicine, 17, 448, 10.1038/nm.2307 Wang, 2013, Co-evolution of had phosphatase and hotdog-fold thioesterase domain function in the menaquinone-pathway fusion proteins bf1314 and pg1653, FEBS Letters, 587, 2851, 10.1016/j.febslet.2013.07.009 Wang, 2015, Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice, The ISME Journal, 9, 1, 10.1038/ismej.2014.99 Waters, 2011, Aetiology of community-acquired neonatal sepsis in low and middle income countries, Journal of Global Health, 1, 154 Westfall, 2018, Longevity extension in drosophila through gut-brain communication, Scientific Reports, 8, 10.1038/s41598-018-25382-z Wickens, 2008, A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial, The Journal of Allergy and Clinical Immunology, 122, 788, 10.1016/j.jaci.2008.07.011 Wieland, 2015, Systematic review: Microbial dysbiosis and nonalcoholic fatty liver disease, Alimentary Pharmacology and Therapeutics, 42, 1051, 10.1111/apt.13376 Wilck, 2017, Salt-responsive gut commensal modulates th17 axis and disease, Nature, 551, 10.1038/nature24628 Xue, 2017, Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia, Scientific Reports, 7, 45176, 10.1038/srep45176 Xiao, 2017, Diabetes enhances il-17 expression and alters the oral microbiome to increase its pathogenicity, Cell Host & Microbe, 22, 120, 10.1016/j.chom.2017.06.014 Xu, 2015, Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula, The ISME Journal, 9, 552, 10.1038/ismej.2014.177 Yosuke, 2015, Dihomo-γ-linolenic acid prevents the development of atopic dermatitis through prostaglandin d1 production in nc/tnd mice, Journal of Dermatological Science, 79, 30, 10.1016/j.jdermsci.2015.03.010 Yuristdoutsch, 2014, Gastrointestinal microbiota–mediated control of enteric pathogens, Annual Review of Genetics, 48, 361, 10.1146/annurev-genet-120213-092421 Zhang, 2018, Huddling remodels gut microbiota to reduce energy requirements in a small mammal species during cold exposure, Microbiome, 6, 103, 10.1186/s40168-018-0473-9