The association of variable number of tandem repeats of the insulin gene with susceptibility to type 1 diabetes among Korean subjects

Diabetes/Metabolism Research and Reviews - Tập 26 Số 6 - Trang 474-480 - 2010
Hye Rim Chung1, Sei Won Yang2, Choong Ho Shin2, Kyong Soo Park3, Young Ah Lee2, Jae Hyun Kim4, Sun Hee Lee5, Ji Hyun Kim6
1Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
2Department of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of Korea
3Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
4Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Republic of Korea
5Department of Pediatrics, Inje University Pusan Paik Hospital, Pusan, Republic of Korea
6Department of Pediatrics, Pohang St Mary's Hospital, Pohang, Republic of Korea

Tóm tắt

AbstractBackgroundThere is ethnic variation in the variable number of tandem repeats of the insulin gene (INS VNTR), one of the susceptibility loci for developing type 1 diabetes (T1D). We evaluated the influence of the genotypes and subdivisions of INS VNTR on the development of T1D in Korean subjects.MethodsThe study included 352 Korean patients, under the age of 18 years who were diagnosed as having T1D, and 356 control subjects. The insulin − 23HphI A/T single nucleotide polymorphism was used as a marker of class I and III alleles. Surrounding polymorphisms at nucleotide positions + 1127, + 1140, + 2331 and + 2336 were determined as subdivisions of INS VNTR.ResultsClasses I/I, I/III and III/III were observed at frequencies of 95.8, 4.2 and 0% among all subjects, respectively. Class I/III genotype was significantly less frequent in patients with T1D than in controls (2.56 versus 5.90%; odds ratio 0.419; P = 0.039). In a subdivision analysis, the ID/ID genotype was decreased among patients (P = 0.017, adjusted P = 0.085) and the IC allele tended to increase. The frequency of the class I/III genotype was significantly lower among patients who were diagnosed when younger than 7 years of age than in controls (odds ratio 0.115; P = 0.011).ConclusionsINS VNTR has predominance of class I over class III alleles and is associated with susceptibility to T1D in Koreans. In addition, INS VNTR shows distinctive susceptibility according to the age at the onset of T1D. Copyright © 2010 John Wiley & Sons, Ltd.

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Diabetes/Metabolism Research and Reviews

Tập 26 Số 6

474-480

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