The argument for increasing selenium intake

Proceedings of the Nutrition Society - Tập 61 Số 2 - Trang 203-215 - 2002
Margaret P. Rayman1
1Centre for Nutrition and Food Safety, School of Biomedical and Life Sciences, University of Surrey, Guildford GU2 7XH, UK

Tóm tắt

The essential trace mineral, Se, is of fundamental importance to human health. As a constituent of selenoproteins it plays both structural and enzymic roles, in the latter context being best known as an antioxidant and catalyst for the production of active thyroid hormone. While Se-deficiency diseases have been recognised for some time, evidence is mounting that less-overt deficiency can also cause adverse health effects and furthermore, that supra-nutritional levels of Se may give additional protection from disease. In the context of these effects, low or diminishing Se status in some parts of the world, notably in some European countries such as the UK, is giving cause for concern. While deficiency has an adverse effect on immunocompetence, Se supplementation appears to enhance the immune response. Se appears to be a key nutrient in counteracting certain viral infections; thus, in a Se-deficient host the benign coxsackie virus becomes virulent, causing heart damage, the influenza virus causes more serious lung pathology and HIV infection progresses more rapidly to AIDS. Long recognised as essential for successful animal reproduction, Se is required for human sperm maturation and sperm motility and may reduce the risk of miscarriage. Deficiency has been linked to adverse mood states. Findings have been equivocal in linking Se to cardiovascular disease risk, although other conditions involving oxidative stress and inflammation have shown some association with Se status. There is growing evidence that higher Se intakes are associated with reduced cancer risk. While persuasive evidence already exists to suggest that additional Se would be beneficial in some health conditions, results from intervention trials underway or planned have the potential to reinforce or refute the argument for increasing Se intake.

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Tài liệu tham khảo

10.1093/carcin/18.8.1541

10.1079/BJN19930057

10.1007/BF02778982

10.1111/j.1471-0528.1999.tb08146.x

10.1016/S0140-6736(82)91028-5

10.1093/ajcn/57.2.256S

10.1093/humrep/13.8.2172

10.1038/sj.ejcn.1600421

10.1001/jama.1996.03540240035027

10.1016/S0002-9149(99)80344-0

10.1136/bmj.314.7078.387

10.1093/oxfordjournals.aje.a114099

10.1164/ajrccm.164.10.2104061

Peretz, 2001, Selenium supplementation in rheumatoid arthritis investigated in a double blind, placebocontrolled trial, Scandinavian Journal of Rheumatology, 30, 208, 10.1080/030097401316909549

1995, Food Habits of Danes 1995 Main Results

10.1046/j.1432-1327.1999.00012.x

10.1097/00003246-198510000-00009

10.1093/oxfordjournals.aje.a009115

Underwood, 1977, Trace Elements in Human and Animal Nutrition, 305

10.1038/sj.ejcn.1600939

10.1096/fj.00-0721fje

MacPherson, 1997, Trace Elements in Man and Animals-9: Proceedings of the Ninth International Symposium on Trace Elements in Man and Animals, 203

1991, Dietary Reference Values for Food Energy and Nutrients for the UK Report on Health and Social Subjects

Bro, 1990, Intake of essential and toxic trace elements in a random sample of Danish men as determined by the duplicate portion sampling technique, Journal of Trace Elements and Electrolytes in Health and Disease, 4, 147

10.1207/S15327914NC401_9

10.1007/BF02783852

Sanders, 1984, Use of selenium in problem cattle herds, Modern Veterinary Practice, 65, 136

10.1093/ajcn/53.5.1323

10.1016/S0197-0186(96)00123-4

Nicol, 1998, Changes in concentrations of plasma selenium and selenoproteins after minor elective surgery: further evidence for a negative acute phase response, Clinical Chemistry, 44, 1764, 10.1093/clinchem/44.8.1764

10.1146/annurev.nutr.19.1.1

Rayman, 2000, Trace Elements in Man and Animals-10: Proceedings of the Tenth International Symposium on Trace elements in Man and Animals, 575

10.1016/S0022-5347(05)65500-0

Stuart, 1982, Environmental factors in bovine and porcine abortion, Veterinary and Human Toxicology, 24, 435

10.1016/0140-6736(91)93130-2

10.1007/978-1-4615-1609-5_9

10.1146/annurev.bi.65.070196.000503

10.1007/978-1-4615-1609-5_13

Behne, 1997, Two new selenoproteins found in the prostatic glandular epithelium and the spermatid nuclei, Biomedical and Environmental Science, 10, 340

10.1016/0098-2997(94)90005-1

10.1093/oxfordjournals.aje.a116097

10.1007/BF02778987

10.1096/fasebj.12.12.1143

Aro, 1998, Environmental Chemistry of Selenium, 81

Whanger, 1996, Metabolism of sub-toxic levels of selenium in animals and humans, Annals of Clinical Laboratory Science, 26, 99

10.1007/978-1-4757-6494-9_2

Stryer, 1995, Biochemistry, 23

10.1097/00042560-199708150-00007

2000, Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

10.1042/cs0890637

Hasselmark, 1993, Selenium supplementation in intrinsic asthma, Allergy, 48, 30

Halliwell, 1999, Free Radicals in Biology and Medicine, 135

Iwanier, 1995, Selenium supplementation enhances the element concentration in blood and seminal fluid but does not change the spermatozoal quality characteristics in subfertile men, Journal of Andrology, 16, 441, 10.1002/j.1939-4640.1995.tb00561.x

10.1111/j.1749-6632.1990.tb00140.x

10.1093/ajcn/53.1.120

Kuklinsky, 1996, Acute pancreatitis, a free radical disease; reducing the lethality with sodium selenite and other antioxidants, Journal of Nutritional and Environmental Medicine, 6, 393

10.1038/sj.ejcn.1600902

10.1079/BJN2000280

Eurola, 2000, Report of the Selenium Monitoring Programme 1997–1999, 24

10.1007/978-1-4757-6494-9

10.1097/00003246-199909000-00017

10.1002/(SICI)1520-670X(1998)11:1<11::AID-JTRA3>3.0.CO;2-6

10.1073/pnas.93.26.15086

10.1093/oxfordjournals.aje.a114493

10.1016/0021-9150(92)90035-F

Alfthan, 2001, Third International Conference on Natural Antioxidants and Anticarcinogens in Food, Health and Disease, 6

10.1093/ajcn/52.6.1087

10.1023/A:1008977320811

Coppinger, 2001, Its Molecular Biology and Role in Human Health, 219, 10.1007/978-1-4615-1609-5_18

10.1006/jfca.1995.1025

Shaw, 1994, Risk factors for asthma symptoms in Kawerau children, New Zealand Journal of Medicine, 107, 387

10.1093/jnci/90.16.1219

10.1097/00001648-200007000-00007

10.1016/S0163-7258(98)00014-X

10.1093/ajcn/70.5.896

10.1177/174182679600300106

10.1093/rheumatology/31.4.281

10.1016/S0140-6736(00)02490-9

10.1159/000051441

10.1055/s-2008-1073025

10.1046/j.1464-410x.1998.00683.x

10.1053/gast.2000.9521

10.1093/biolreprod/8.5.625

10.1111/j.1532-5415.2000.tb02603.x

10.1093/jnci/90.16.1184

Barrington, 1997, Selenium and recurrent miscarriage, Journal of Obstetrics and Gynaecology, 17, 199, 10.1080/01443619750113870

10.1089/aid.1994.10.1451

10.1007/978-1-4615-1609-5_11

10.1007/BF02917222

1999, Total Diet Study - Aluminium, Arsenic, Cadmium, Chromium, Copper, Lead, Mercury, Nickel, Selenium, Tin and Zinc. Food Surveillance Information Sheet, 191

10.1056/NEJM199810153391604

10.1096/fj.00-0655fje

10.1126/science.279.5347.102

10.1016/0021-9150(88)90109-8

Sunde, 1997, In Handbook of Nutritionally Essential Mineral Elements, 493

10.1530/jrf.0.1060291

10.1093/jnci/82.10.864

Cole, 2000, Concepts in Pig Science 2000, 149

10.1093/oxfordjournals.aje.a009574

10.1016/S0014-5793(99)00073-3

10.1006/abbi.1994.1105

10.1093/oxfordjournals.aje.a010016

10.1016/S0946-672X(02)80002-5

10.1002/(SICI)1098-2744(199912)26:4<213::AID-MC1>3.0.CO;2-Z

10.1007/978-1-4757-6494-9

10.1038/nm0595-433

Benton, 1991, Biological selenium supplementation improves mood in a double-blind crossover trial, Psychopharmacology, 29, 1092

10.1097/00042560-199904150-00015

Taylor, 1999, Chemoprotective mechanisms of selenium in cancer and AIDS: evidence for the involvement of novel selenoprotein genes, InFo Onkologi Suppl, 2, 7

10.1002/biof.5520140117

10.1378/chest.100.6.1619

Ip, 1998, Lessons from basic research in selenium and cancer prevention, Journal of Nutrition, 128, 1845, 10.1093/jn/128.11.1845

10.1111/j.1471-0528.1996.tb09663.x

Gregory, 2000, National Diet and Nutrition Survey: Young People Aged 4 to 18 years, 1

1997, Dietary intake of Selenium Food Surveillance Information Sheet, 126

10.1079/PHN2001143

Combs, 2001, Its Molecular Biology and Role in Human Health, 205, 10.1007/978-1-4615-1609-5_17

10.1385/BTER:73:2:97

10.1126/science.285.5432.1393

10.1016/S0006-2952(97)00103-2

Behne, 2000, Trace Elements in Man and Animals-10: Proceedings of the Tenth International Symposium on Trace elements in Man and Animals, 29

Knekt, 2002, Handbook of Antioxidants, 665

Joffe, 1993, The Thyroid Axis and Psychiatric Illness, 195

Kukreja, 1998, Effect of selenium deficiency and its supplementation on DTH response, antibody forming cells and antibody titre, Indian Journal of Experimental Biology, 36, 203

10.1079/PNS19910037

10.3168/jds.S0022-0302(79)83400-1

10.1016/0006-3223(95)00085-2

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Proceedings of the Nutrition Society

Tập 61 Số 2

203-215

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