The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide‐induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities

Journal of Biochemical and Molecular Toxicology - Tập 33 Số 6 - 2019
Parham Taslimi1, Fatih Mehmet Kandemir2, Yeliz Demir1, Mustafa İleritürk2, Yusuf Temel3, Cüneyt Çağlayan4, İlhami Gülçın1
1Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey
2Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey
3Department of Solhan School of Health Services, Bingol University, Bingol, Turkey
4Department of Biochemistry, Faculty of Veterinary Medicine, Bingol University, Bingol, Turkey

Tóm tắt

AbstractChrysin (CH) or 5,7‐dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes including carbonic anhydrase, aldose reductase, paraoxonase‐1, α‐glycosidase, acetylcholinesterase, and butyrylcholinesterase enzyme activities in the brain, heart, testis, liver, and kidney tissues of rats. Thirty‐five adult male Wistar rats were used. The animals were pretreated with CH (25 and 50 mg/kg b.w.) for seven days before administering a single dose of CYP (200 mg/kg b.w.) on the seventh day. In all the tissues, the treatment of CH significantly regulated these enzyme activities in CYP‐induced rats. These results showed that CH exhibited an ameliorative effect against CYP‐induced brain, heart, liver, testis, and kidney toxicity.

Từ khóa


Tài liệu tham khảo

10.1016/j.cbi.2015.02.021

10.1007/s11356-018-2242-5

10.3109/19390211.2015.1103827

10.1111/jfbc.12398

10.1016/j.biopha.2018.06.161

10.1002/jbt.22030

10.1016/j.biopha.2018.03.119

10.1002/jbt.21960

10.3390/scipharm85010004

10.1007/s11010-013-1830-4

10.1002/jbt.21935

10.1002/jbt.21889

10.3906/kim-1501-51

10.1002/jbt.22010

10.1111/jfbc.12720

10.1002/slct.201801019

10.1080/13543776.2018.1487400

10.1111/jfbc.12516

10.1111/cbdd.13149

Rezai M., 2018, Turk. J. Chem, 42, 808

10.1080/13813455.2017.1360914

10.1016/j.molstruc.2018.05.077

10.1002/jbt.22009

10.1002/jbt.22006

10.1016/j.bioorg.2017.08.012

10.1016/j.molstruc.2017.11.079

10.1002/jbt.21995

10.1002/ardp.201700314

10.1002/jbt.22042

10.3109/13880209.2014.908399

Türkan F., 2018, Arch. Physiol. Biochem, 1

10.1002/jbt.22041

10.1111/cbdd.12746

10.1021/jm00161a033

10.1002/jbt.21971

10.1080/14756366.2017.1368019

10.1002/jbt.21931

10.1016/j.foodchem.2010.03.088

10.1002/jbt.22191

10.1002/ardp.201700045

10.1080/14756366.2016.1198901

10.1080/14756366.2016.1244533

10.1016/j.bioorg.2017.07.010

10.1002/jbt.21897

10.1002/bmc.2761

10.1002/jbt.21956

10.1016/j.foodchem.2009.01.042

10.1517/14740338.6.2.183

10.1007/s00204-011-0774-2

10.1080/10942912.2016.1168438

10.1016/j.cbi.2008.05.003

10.3109/14756366.2011.604318

10.15666/aeer/1503_16851696

10.1089/jmf.2010.0197

10.1080/13813455.2018.1470646

10.1016/j.etap.2015.11.024

10.1016/j.cbi.2017.01.021

10.1016/j.ijbiomac.2018.08.001

10.1016/j.ijbiomac.2018.08.004

10.1016/j.bmcl.2010.12.077

10.1111/j.1365-2362.1994.tb02253.x

10.1016/S1262-3636(07)70268-9

10.1016/j.bmc.2015.04.019

10.1080/14756366.2016.1189422

10.1002/jbt.22031

Thông tin
Thông tin xuất bản

Journal of Biochemical and Molecular Toxicology

Tập 33 Số 6

Thông tin tác giả