The amygdala and ventromedial prefrontal cortex: functional contributions and dysfunction in psychopathy

Philosophical Transactions of the Royal Society B: Biological Sciences - Tập 363 Số 1503 - Trang 2557-2565 - 2008
James Blair1
1Mood & Anxiety Program, National Institute of Mental Health, National Institutes of Health15k North Drive, Bethesda, MD 20892, USA

Tóm tắt

The current paper examines the functional contributions of the amygdala and ventromedial prefrontal cortex (vmPFC) and the evidence that the functioning of these systems is compromised in individuals with psychopathy. The amygdala is critical for the formation of stimulus–reinforcement associations, both punishment and reward based, and the processing of emotional expressions. vmPFC is critical for the representation of reinforcement expectancies and, owing to this, decision making. Neuropsychological and neuroimaging data from individuals with psychopathy are examined. It is concluded that these critical functions of the amygdala and vmPFC, and their interaction, are compromised in individuals with the disorder. It is argued that these impairments lead to the development of psychopathy.

Từ khóa


Tài liệu tham khảo

10.1016/S0959-4388(02)00301-X

10.1038/nature03086

Amaral D.G, 1992, The amygdala: neurobiological aspects of emotion, memory, and mental dysfunction, 1

10.1523/JNEUROSCI.23-29-09632.2003

10.1523/JNEUROSCI.21-18-j0001.2001

10.1523/JNEUROSCI.19-13-05473.1999

10.1093/brain/123.11.2189

10.1001/archpsyc.62.7.799

10.1098/rstb.2002.1220

10.1016/S0278-2626(03)00276-8

10.1196/annals.1401.017

10.1093/brain/122.5.883

10.1023/A:1012277125119

10.1016/j.paid.2003.12.001

Blair R.J.R Mitchell D.G.V& Blair K.S The psychopath: emotion and the brain. 2005 Oxford UK:Blackwell.

10.1016/j.paid.2005.11.031

10.1523/JNEUROSCI.1640-06.2006

10.1016/j.neuroimage.2006.11.048

10.1016/j.tics.2004.10.003

10.1016/S0959-4388(00)00078-7

10.1111/j.1469-7610.2004.00398.x

10.1037/0021-843X.115.3.552

10.1016/j.neuroimage.2006.08.060

Burdach K. F. 1819–1822 Vom baue und Leben des Gehirns . Leipzig.

10.1016/0191-8869(95)00220-0

10.1038/74783

10.1523/JNEUROSCI.22-11-04563.2002

10.1037/0022-006X.64.4.783

10.1192/bjp.bp.105.018150

Davis M, 2000, The amygdala: a functional analysis, 289

10.1192/bjp.bp.106.021410

10.1038/380069a0

10.3758/CABN.5.4.388

10.1016/j.neuron.2006.07.029

10.1111/j.1749-6632.2003.tb07085.x

10.1093/brain/awg180

10.1001/archpsyc.65.5.586

10.1016/j.neuroimage.2005.11.003

Frick P.J, 1995, Callous-unemotional traits and conduct problems: a two-factor model of psychopathy in children, Issues Criminological Legal Psychol, 24, 47

10.1023/A:1023899703866

10.1037/0021-843X.115.4.815

10.1016/j.biopsych.2004.06.030

10.1523/JNEUROSCI.22-24-10829.2002

10.1016/0028-3932(81)90049-X

10.1523/JNEUROSCI.1010-06.2006

Hare R.D Psychopathy: theory and research. 1970 New York NY:Wiley.

Hare R.D The Hare Psychopathy Checklist-Revised. 1991 Toronto Canada:Multi-Health Systems.

Hare R.D Hare Psychopathy Checklist-Revised (PCL-R). 2nd edn. 2003 Toronto Canada:Multi Health Systems.

10.1111/j.1469-8986.1978.tb01356.x

10.1037/0022-006X.56.5.741

10.1038/nn1238

10.1523/JNEUROSCI.3048-05.2006

10.1007/BF00237911

10.1523/JNEUROSCI.1921-04.2004

10.1002/cne.900350502

10.1016/S0006-3223(01)01222-7

10.1097/01.wco.0000173463.24758.f6

10.1037/1528-3542.2.4.398

10.1016/j.neuroimage.2005.07.060

10.1016/S1053-8119(03)00393-8

10.1093/cercor/13.10.1023

LeDoux J The emotional brain. 1998 New York NY:Weidenfeld & Nicolson.

10.1037/0021-843X.109.3.373

10.1037/1528-3542.2.2.91

10.1037/h0047232

10.1037/0021-843X.116.1.155

10.1016/j.neubiorev.2007.08.003

10.1016/j.neuroimage.2006.11.044

10.1176/appi.ajp.2007.07071145

10.1016/S0028-3932(02)00056-8

10.1037/0021-843X.115.3.559

10.1016/j.neuroimage.2006.10.012

10.1016/S0896-6273(02)00974-1

10.1016/j.paid.2004.02.008

10.1038/383812a0

10.3758/CABN.3.3.207

10.1016/j.neuroimage.2006.02.022

10.1037/0021-843X.95.3.252

10.1037/0021-843X.96.2.145

10.1523/JNEUROSCI.23-21-07931.2003

10.1016/j.neuroimage.2005.08.047

10.1038/nature04676

Patrick C.J. 2006 New York NY:Guilford Press.

10.1037/0021-843X.102.1.82

10.1016/S0079-6123(03)14412-3

10.1038/nn1463

10.1038/86110

10.1016/S0006-3223(03)00171-9

10.1111/j.1749-6632.2003.tb07070.x

10.1016/j.biopsych.2006.06.004

10.1016/j.biopsych.2006.07.021

10.1523/JNEUROSCI.23-35-11054.2003

10.1016/j.tics.2007.01.004

10.1016/j.neuron.2005.07.018

10.1016/S0896-6273(03)00474-4

10.1097/00001756-200206120-00009

10.1111/1467-8721.ep10836912

10.1016/S0006-3223(98)00251-0

10.1111/j.1469-8986.1991.tb02192.x

10.1016/S1053-8119(03)00303-3

10.1037/0022-006X.65.2.292.b