Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Phản ứng cấp tính của homocysteine sau bữa ăn đối với việc bổ sung vitamin và khoáng chất đa dạng với bữa ăn tiêu chuẩn không bị suy giảm ở người lớn tuổi so với người trẻ tuổi
Tóm tắt
Vitamin nhóm B là cần thiết cho việc điều chỉnh phức tạp của homocysteine và chuyển hóa một carbon (1C). Các bổ sung dinh dưỡng thường được người lớn tuổi sử dụng để đối phó với sự thiếu hụt dinh dưỡng. Tuy nhiên, việc sử dụng vitamin nhóm B từ các bổ sung trong chuyển hoá 1C sau bữa ăn có thể bị thay đổi theo độ tuổi do sự hấp thụ dinh dưỡng và điều chỉnh chuyển hóa bị suy giảm. Mặc dù có ảnh hưởng đến sức khỏe và tình trạng dinh dưỡng, nhưng phản ứng của các chất chuyển hóa 1C sau bữa ăn chưa được đặc trưng ở người lớn tuổi. Những người tham gia khỏe mạnh ở độ tuổi lớn hơn (n = 20, 65–76 tuổi) và trẻ hơn (n = 20, 19–30 tuổi) đã được tuyển mộ thông qua các quảng cáo trực tuyến và in ấn tại Auckland, New Zealand. Những người tham gia đã tiêu thụ một loại vitamin và khoáng chất đa dạng cùng với một bữa sáng tiêu chuẩn. Mẫu máu được thu thập tại thời điểm cơ bản và hàng giờ trong 4 giờ sau khi tiêu thụ. Các chất chuyển hóa 1C trong huyết tương (betaine, choline, cysteine, dimethylglycine, glycine, methionine, serine) đã được định lượng bằng phương pháp sắc ký lỏng ghép nối với phổ khối. Homocysteine huyết thanh, folate và vitamin B12 được định lượng trên máy phân tích tự động Cobas e411. Người lớn tuổi có nồng độ homocysteine lúc đói cao hơn (người lớn tuổi: 14.0 ± 2.9 µmol/L; người trẻ: 12.2 ± 2.5 µmol/L; p = 0.036) mặc dù có nồng độ folate cao hơn (người lớn tuổi: 36.7 ± 17.4 nmol/L; người trẻ: 21.6 ± 7.6 nmol/L; p < 0.001) và nồng độ vitamin B12 tương tự (p = 0.143) so với người trẻ. Tuy nhiên, một sự giảm sút sau bữa ăn tương tự về homocysteine đã được tìm thấy ở cả hai nhóm tuổi là người lớn và người trẻ đối với bữa ăn kết hợp và bổ sung. Ngoại trừ sự giảm nhanh hơn của cystathionine ở người lớn tuổi (p = 0.003), phản ứng sau bữa ăn của các chất chuyển hóa 1C khác là tương tự giữa người trẻ và người lớn tuổi. Người lớn tuổi khỏe mạnh dường như duy trì khả năng phản ứng sau bữa ăn của chuyển hóa 1C tương tự như ở người trẻ tuổi, được hỗ trợ bởi sự giảm tương tự về nồng độ homocysteine sau bữa ăn.
Từ khóa
#Vitamin B #chuyển hóa homocysteine #người lớn tuổi #chất chuyển hóa một carbon #bổ sung dinh dưỡngTài liệu tham khảo
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