The X‐box binding protein‐1 transcription factor is required for plasma cell differentiation and the unfolded protein response

Immunological Reviews - Tập 194 Số 1 - Trang 29-38 - 2003
Neal N. Iwakoshi1, Ann–Hwee Lee1, Laurie H. Glimcher1,2
1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
2Department of Medicine, Harvard Medical School, Boston, MA USA

Tóm tắt

Summary:  X‐box binding protein‐1 (XBP‐1) is a transcription factor essential for plasma cell differentiation. XBP‐1 transcripts are found at high levels in plasma cells from rheumatoid synovium and myeloma cell lines. Lymphoid chimeras deficient in XBP‐1 have a profound defect in plasma cell differentiation, with few plasma cells in their periphery and severely reduced serum immunoglobulin levels. When introduced into B‐lineage cells, XBP‐1 initiates plasma cell differentiation. XBP‐1 is also the mammalian homologue of the yeast transcription factor Hac1p, an important component of the unfolded protein response (UPR). The UPR allows cells to tolerate conditions of endoplasmic reticulum (ER) stress caused by misfolded proteins. Studies examining the relationship between plasma cell differentiation, XBP‐1, and the UPR demonstrate that this novel signaling system is vital for plasma cell differentiation. Signals that induce plasma cell differentiation and the UPR cooperate via XBP‐1 to induce terminal B‐cell differentiation. Additionally, XBP‐1 plays an important role in the regulation of interleukin‐6 production, a cytokine essential for plasma cell survival.

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Tài liệu tham khảo

Schwartz RS, 1993, Fundamental Immunology, 1033

Theofilopoulos AN, 1982, Autoimmune diseases: immunopathology and etiopathogenesis, Am J Pathol, 108, 319

10.1126/science.279.5353.1052

10.1038/379346a0

10.1146/annurev.immunol.16.1.421

10.1016/1074-7613(95)90155-8

10.1126/science.2321018

10.1073/pnas.88.10.4309

10.1093/nar/24.10.1855

10.1002/jlb.63.2.139

10.1084/jem.177.6.1821

10.1128/MCB.10.4.1609

10.1002/j.1460-2075.1990.tb07434.x

10.1002/aja.1001970207

10.1093/jb/117.2.303

10.1084/jem.183.2.393

10.1101/gad.4.5.849

10.3109/08830180109056723

10.4049/jimmunol.162.5.3053

10.1073/pnas.90.10.4528

10.1091/mbc.1.1.27

10.1016/0092-8674(94)90321-2

10.1126/science.276.5312.596

10.1016/S1074-7613(02)00335-7

10.4049/jimmunol.163.2.611

10.1006/smim.1998.0115

10.4049/jimmunol.158.7.3197

10.1038/ni1201-1103

10.1126/science.275.5299.540

10.1126/science.276.5312.589

10.1016/S1074-7613(00)80638-X

10.1016/S1074-7613(01)00085-1

10.1016/S0955-0674(00)00219-2

10.1038/332462a0

10.1016/S0092-8674(01)00505-0

10.1016/S0092-8674(01)00612-2

10.1016/S0092-8674(01)00611-0

10.1038/415092a

10.1016/0092-8674(93)90648-A

10.1016/S0092-8674(00)81360-4

10.1101/gad.12.12.1812

10.1038/16729

10.1101/gad.964702

10.1016/S0092-8674(01)00623-7

10.1146/annurev.immunol.17.1.701

10.1038/ni907

10.1182/blood.V74.1.1.1

10.1002/eji.1830181122

10.1182/blood.V74.4.1360.1360

10.1016/0090-1229(89)90175-X

10.1093/rheumatology/34.4.321

10.4049/jimmunol.143.12.3949

Samoilova EB, 1998, IL‐6‐deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL‐6 in the activation and differentiation of autoreactive T cells, J Immunol, 161, 6480, 10.4049/jimmunol.161.12.6480

10.1111/j.1600-065X.1995.tb00093.x

10.1073/pnas.022643999

Wen XY, 1999, Identification of c‐myc promoter‐binding protein and X‐box binding protein 1 as interleukin‐6 target genes in human multiple myeloma cells, Int J Oncol, 15, 173

10.1016/S0065-2776(08)60740-3

10.1038/368339a0

10.1126/science.274.5291.1379

10.1126/science.1061965

10.1038/35085509

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Immunological Reviews

Tập 194 Số 1

29-38

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