The Traditional Japanese Herbal Medicine Hachimijiogan Elicits Neurite Outgrowth Effects in PC12 Cells and Improves Cognitive in AD Model Rats via Phosphorylation of CREB

Ayer-LeLievre, 1988, Expression of the beta-nerve growth factor gene in hippocampal neurons., Science, 240, 1339, 10.1126/science.2897715

Canu, 2017, The intersection of NGF/TrkA signaling and amyloid precursor protein processing in Alzheimer’s disease neuropathology., Int. J. Mol. Sci., 18, 10.3390/ijms18061319

Carlezon, 2005, The many faces of CREB., Trends Neurosci., 28, 436, 10.1016/j.tins.2005.06.005

Frankland, 2005, The organization of recent and remote memories., Nat. Rev. Neurosci., 6, 119, 10.1038/nrn1607

Gong, 2004, Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment., J. Clin. Invest., 114, 1624, 10.1172/JCI22831

Hirokawa, 1994, Effect of hachimijiogan, an oriental herbal medicinal mixture, on experimental amnesia in mice., Biol. Pharm. Bull., 17, 1182, 10.1248/bpb.17.1182

Hirokawa, 1996, Effect of Hachimi-jio-gan on scopolamine-induced memory impairment and on acetylcholine content in rat brain., J. Ethnopharmacol., 50, 77, 10.1016/0378-8741(95)01332-6

Ikeda, 2001, Selective and long-term learning impairment following neonatal hypoxic-ischemic brain insult in rats., Behav. Brain Res., 118, 17, 10.1016/S0166-4328(00)00287-4

Iwasaki, 2004, A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine “ba wei di huang wan” in the treatment of dementia., J. Am. Geriatr. Soc., 52, 1518, 10.1111/j.1532-5415.2004.52415.x

Jonhagen, 2000, Nerve growth factor treatment in dementia., Alzheimer Dis. Assoc. Disord., 14, S31, 10.1097/00002093-200000001-00006

Kaplan, 2000, Neurotrophin signal transduction in the nervous system., Curr. Opin. Neurobiol., 10, 381, 10.1016/S0959-4388(00)00092-1

Kubota, 2013, Yokukansan, a traditional Japanese herbal medicine, promotes neurite outgrowth in PC12 cells through the activation of extracellular signal regulated kinase 1/2 and phosphatidylinositol 3-kinase/Akt., J. Tradit. Med., 30, 102

Lonze, 2002, Function and regulation of CREB family transcription factors in the nervous system., Neuron, 35, 605, 10.1016/S0896-6273(02)00828-0

Manning, 2017, Reward network immediate early gene expression in mood disorders., Front. Behav. Neurosci., 11, 10.3389/fnbeh.2017.00077

McGirr, 2016, Specific inhibition of phosphodiesterase-4B results in anxiolysis and facilitates memory acquisition., Neuropsychopharmacology, 41, 1080, 10.1038/npp.2015.240

Medina, 2011, Therapeutic utility of phosphodiesterase type I inhibitors in neurological conditions., Front. Neurosci., 18, 10.3389/fnins.2011.00021

Menniti, 2006, Phosphodiesterases in the CNS: targets for drug development., Nat. Rev. Drug Discov., 5, 660, 10.1038/nrd2058

Monnet, 2005, Transcription and neurotrophic factors in affective disorders: new trends in understanding the action of antidepressant drugs., Curr. Psychiatry Rev., 1, 313, 10.2174/157340005774575082

Moriyama, 2017, Effect of hachimijiogan on memory impairment induced by beta-amyloid combined with cerebral ischemia in rats., Tradit. Kampo Med., 4, 51, 10.1002/tkm2.1069

Morris, 1981, Spatial localization does not require the presence of local cues., Learn. Motiv., 12, 239, 10.1016/0023-9690(81)90020-5

Nakagawa, 2002, Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein., J. Neurosci., 22, 3673, 10.1523/JNEUROSCI.22-09-03673.2002

Nogami, 2013, Effect of Yokukansan on memory disturbance in an animal model of cerebrovascular dementia., J. Tradit. Med., 30, 164

Obara, 2002, The signaling pathway of neurotrophic factor biosynthesis., Drug News Perspect., 15, 290, 10.1358/dnp.2002.15.5.840042

O’Donnell, 2004, Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)., Trends Pharmacol. Sci., 25, 158, 10.1016/j.tips.2004.01.003

Phillips, 1991, BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer’s disease., Neuron, 7, 695, 10.1016/0896-6273(91)90273-3

Pollack, 2002, Small molecule Trk receptor agonists and other neurotrophic factor mimetics., Curr. Drug Targets CNS Neurol. Disord., 1, 59, 10.2174/1568007023339490

Rahimi, 2010, A review of the herbal phosphodiesterase inhibitors; future perspective of new drugs., Cytokine, 49, 123, 10.1016/j.cyto.2009.11.005

Skaper, 2008, The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors., CNS Neurol..Disord..Drug Targets, 7, 46, 10.2174/187152708783885174

Suzuki, 2011, Upregulation of CREB-mediated transcription enhances both short- and long-term memory., J. Neurosci., 31, 8786, 10.1523/JNEUROSCI.3257-10.2011

Uchida, 2013, Cholinergic involvement and synaptic dynamin 1 expression in Yokukansan-mediated improvement of spatial memory in a rat model of early Alzheimer’s disease., Phytother. Res., 7, 966, 10.1002/ptr.4818

Vitolo, 2002, Amyloid beta-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibilty by drugs that enhance cAMP signaling., Proc. Natl. Acad. Sci. U.S.A., 99, 13217, 10.1073/pnas.172504199

Yamamoto-Sasaki, 1999, Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type., Brain Res., 824, 300, 10.1016/S0006-8993(99)01220-2