The Tablet Formulation of Lopinavir/Ritonavir Provides Similar Bioavailability to the Soft-Gelatin Capsule Formulation With Less Pharmacokinetic Variability and Diminished Food Effect
Tóm tắt
Từ khóa
Tài liệu tham khảo
Law, 2004, Ritonavir-PEG 8000 amorphous solid dispersions: in vitro and in vivo evaluations., J Pharm Sci, 93, 563, 10.1002/jps.10566
Leuner, 2000, Improving drug solubility for oral delivery using solid dispersions., Eur J Pharm Biopharm, 50, 47, 10.1016/S0939-6411(00)00076-X
Breitenbach, 2002, Melt extrusion: from process to drug delivery technology., Eur J Pharm Biopharm, 54, 107, 10.1016/S0939-6411(02)00061-9
Breitenbach, 2006, Melt extrusion can bring new benefits to HIV therapy: the example of Kaletra tablets., American Journal of Drug Delivery, 4, 61, 10.2165/00137696-200604020-00001
Schuirman, 1987, A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability., J Pharmacokinet Biopharm, 15, 657, 10.1007/BF01068419