The Surgically Induced Stress Response

Journal of Parenteral and Enteral Nutrition - Tập 37 Số 5S - 2013
Celeste C. Finnerty1,2, Nigel Tapiwa Mabvuure1, Arham Ali1, Rosemary A. Kozar3, David N. Herndon1
1Department of Surgery, Shriners Hospitals for Children–Galveston and the University of Texas Medical Branch, Galveston, Texas
2The Institute for Translational Science and the Sealy Center for Molecular Medicine, The University of Texas Medical Branch
3Department of Surgery, University of Texas–Houston Health Science Center, Houston, Texas

Tóm tắt

The stress response to surgery, critical illness, trauma, and burns encompasses derangements of metabolic and physiological processes that induce perturbations in the inflammatory, acute phase, hormonal, and genomic responses. Hypermetabolism and hypercatabolism result, leading to muscle wasting, impaired immune function and wound healing, organ failure, and death. The surgery‐induced stress response is largely similar to that triggered by traumatic injuries; the duration of the stress response, however, varies according to the severity of injury (surgical or traumatic). This spectrum of injuries and insults ranges from small lacerations to severe insults such as large poly‐traumatic and burn injuries. Burn injuries provide an extreme model of trauma induced stress responses that can be used to study the long‐term effects of a prolonged stress response. Although the stress response to acute trauma evolved to confer improved chances of survival following injury, in modern surgical practice the stress response can be detrimental.

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Journal of Parenteral and Enteral Nutrition

Tập 37 Số 5S

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