The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
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Morelli, 2013, Ectopic fat: The true culprit linking obesity and cardiovascular disease?, Thromb. Haemost, 110, 651, 10.1160/TH13-04-0285
Gaggini, 2015, Not all fats are created equal: Adipose vs. Ectopic fat, implication in cardiometabolic diseases, Horm. Mol. Biol. Clin. Investig., 22, 7, 10.1515/hmbci-2015-0006
Gaggini, 2013, Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease, Nutrients, 5, 1544, 10.3390/nu5051544
2014, Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome, Lancet Diabetes Endocrinol., 2, 901, 10.1016/S2213-8587(14)70032-4
Bray, 2014, Visceral adipose tissue and ectopic fat deposition, Handbook of Obesity, Volume 1, 237
Lim, 2011, Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol, Diabetologia, 54, 2506, 10.1007/s00125-011-2204-7
Gastaldelli, 2012, The role of cardiac fat in insulin resistance, Curr. Opin. Clin. Nutr. Metab. Care, 15, 523, 10.1097/MCO.0b013e328358be7b
Gaborit, 2012, Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: Relationship to metabolic profile, cardiac function and visceral fat, Int. J. Obes., 36, 422, 10.1038/ijo.2011.117
Boden, 2001, Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects, Diabetes, 50, 1612, 10.2337/diabetes.50.7.1612
Schrauwen, 2004, Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes, Diabetes, 53, 1412, 10.2337/diabetes.53.6.1412
Boden, 2011, Obesity, insulin resistance and free fatty acids, Curr. Opin. Endocrinol. Diabetes Obes., 18, 139, 10.1097/MED.0b013e3283444b09
Kalhan, 2008, Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans, Metabolism, 57, 305, 10.1016/j.metabol.2007.10.003
Gastaldelli, 2007, Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects, Gastroenterology, 133, 496, 10.1053/j.gastro.2007.04.068
Gastaldelli, 2006, The effect of rosiglitazone on the liver: Decreased gluconeogenesis in patients with type 2 diabetes, J. Clin. Endocrinol. Metab., 91, 806, 10.1210/jc.2005-1159
Belfort, 2006, A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis, N. Engl. J. Med., 355, 2297, 10.1056/NEJMoa060326
Sanyal, 2010, Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis, N. Engl. J. Med., 362, 1675, 10.1056/NEJMoa0907929
Tordjman, 2003, Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells, J. Biol. Chem., 278, 18785, 10.1074/jbc.M206999200
Hellerstein, 1999, De novo lipogenesis in humans: Metabolic and regulatory aspects, Eur. J. Clin. Nutr., 53, S53, 10.1038/sj.ejcn.1600744
Donnelly, 2005, Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease, J. Clin. Investig., 115, 1343, 10.1172/JCI23621
Timlin, 2005, Temporal pattern of de novo lipogenesis in the postprandial state in healthy men, Am. J. Clin. Nutr., 81, 35, 10.1093/ajcn/81.1.35
Flannery, 2012, Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly, Diabetes, 61, 2711, 10.2337/db12-0206
Ma, 2015, Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: The cardiovascular health study, Am. J. Clin. Nutr., 101, 153, 10.3945/ajcn.114.092601
Cai, 2005, Local and systemic insulin resistance resulting from hepatic activation of ikk-beta and nf-kappab, Nat. Med., 11, 183, 10.1038/nm1166
Ansorena, 2001, Postprandial de novo lipogenesis and metabolic changes induced by a high-carbohydrate, low-fat meal in lean and overweight men, Am. J. Clin. Nutr., 73, 253, 10.1093/ajcn/73.2.253
Bechmann, 2012, The interaction of hepatic lipid and glucose metabolism in liver diseases, J. Hepatol., 56, 952, 10.1016/j.jhep.2011.08.025
Shimano, 1999, Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes, J. Biol. Chem., 274, 35832, 10.1074/jbc.274.50.35832
Dentin, 2004, Hepatic glucokinase is required for the synergistic action of chrebp and SREBP-1c on glycolytic and lipogenic gene expression, J. Biol. Chem., 279, 20314, 10.1074/jbc.M312475200
Herman, 2012, A novel chrebp isoform in adipose tissue regulates systemic glucose metabolism, Nature, 484, 333, 10.1038/nature10986
Musso, 2009, Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD), Prog. Lipid. Res., 48, 1, 10.1016/j.plipres.2008.08.001
Schwarz, 2003, Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets, Am. J. Clin. Nutr., 77, 43, 10.1093/ajcn/77.1.43
Shimomura, 2000, Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice, Mol. Cell, 6, 77, 10.1016/S1097-2765(05)00010-9
Boden, 2013, Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue, Obesity, 21, 1208, 10.1002/oby.20134
Guo, 2000, De novo lipogenesis in adipose tissue of lean and obese women: Application of deuterated water and isotope ratio mass spectrometry, Int. J. Obes. Relat. Metab. Disord., 24, 932, 10.1038/sj.ijo.0801256
Vendrell, 2012, De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery, PLoS ONE, 7, e31280, 10.1371/journal.pone.0031280
Armstrong, M.J., Hull, D., Guo, K., Barton, D., Hazlehurst, J.M., Gathercole, L.L., Nasiri, M., Yu, J., Gough, S.C., and Newsome, P.N. (2015). Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatophepatitis. J. Hepatol.
Beysen, 2008, A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes, J. Lipid. Res., 49, 2657, 10.1194/jlr.M800165-JLR200
Krauss, 2004, Lipids and lipoproteins in patients with type 2 diabetes, Diabetes Care, 27, 1496, 10.2337/diacare.27.6.1496
Schrauwen, 2011, Lipotoxicity in type 2 diabetic cardiomyopathy, Cardiovasc Res., 92, 10, 10.1093/cvr/cvr212
Zammit, 2013, Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia, Biochem. J., 451, 1, 10.1042/BJ20121689
Yen, 2015, Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism, J. Lipid Res., 56, 489, 10.1194/jlr.R052902
Perry, 2014, The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes, Nature, 510, 84, 10.1038/nature13478
Adiels, 2006, Overproduction of large vldl particles is driven by increased liver fat content in man, Diabetologia, 49, 755, 10.1007/s00125-005-0125-z
Fabbrini, 2008, Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease, Gastroenterology, 134, 424, 10.1053/j.gastro.2007.11.038
Wree, 2014, Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients, Metabolism, 63, 1542, 10.1016/j.metabol.2014.09.001
Mahdessian, 2014, TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content, Proc. Natl. Acad. Sci. USA, 111, 8913, 10.1073/pnas.1323785111
Dongiovanni, 2015, Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease, Hepatology, 61, 506, 10.1002/hep.27490
Mittendorfer, 2009, Relationship between body fat mass and free fatty acid kinetics in men and women, Obesity, 17, 1872, 10.1038/oby.2009.224
Smirnova, 2006, ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells, EMBO Rep., 7, 106, 10.1038/sj.embor.7400559
Haemmerle, 2006, Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase, Science, 312, 734, 10.1126/science.1123965
Shaw, 2013, HSL and ATGL: The movers and shakers of muscle lipolysis, J. Physiol., 591, 6137, 10.1113/jphysiol.2013.265199
Huijsman, 2009, Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice, Am. J. Physiol. Endocrinol. Metab., 297, E505, 10.1152/ajpendo.00190.2009
Brown, 2010, CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance, J. Lipid Res., 51, 3306, 10.1194/jlr.M010256
Ong, 2010, Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning, Hepatology, 53, 116, 10.1002/hep.24006
Wu, 2011, Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis, Hepatology, 54, 122, 10.1002/hep.24338
Fuchs, 2012, Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice, Hepatology, 56, 270, 10.1002/hep.25601
Pulinilkunnil, 2013, Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity, Int. J. Obes., 38, 205, 10.1038/ijo.2013.103
Kraemer, 2002, Hormone-sensitive lipase: Control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis, J. Lipid. Res., 43, 1585, 10.1194/jlr.R200009-JLR200
Osuga, 2000, Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity, Proc. Natl. Acad. Sci. USA, 97, 787, 10.1073/pnas.97.2.787
Haemmerle, 2002, Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis, J. Biol. Chem., 277, 4806, 10.1074/jbc.M110355200
Gastaldelli, 1999, Assessment of methods for improving tracer estimation of non-steady-state rate of appearance, J. Appl. Physiol., 87, 1813, 10.1152/jappl.1999.87.5.1813
Natali, 1998, Effects of acute alpha 2-blockade on insulin action and secretion in humans, Am. J. Physiol., 274, E57
Karpe, 2011, Fatty acids, obesity, and insulin resistance: Time for a reevaluation, Diabetes, 60, 2441, 10.2337/db11-0425
Gastaldelli, 2011, Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus, Diabetes Res. Clin. Pract., 93, S60, 10.1016/S0168-8227(11)70015-8
Groop, 1989, Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance, J. Clin. Investig., 84, 205, 10.1172/JCI114142
Brehm, 2006, Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle, Diabetes, 55, 136, 10.2337/diabetes.55.01.06.db05-1286
Wang, 2006, Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating Pten or inhibiting Akt kinase, Diabetes, 55, 2301, 10.2337/db05-1574
Itani, 2002, Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α, Diabetes, 51, 2005, 10.2337/diabetes.51.7.2005
Bugianesi, 2005, Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: Sites and mechanisms, Diabetologia, 48, 634, 10.1007/s00125-005-1682-x
Fabbrini, 2012, Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects, J. Lipid Res., 53, 321, 10.1194/jlr.D020321
Fabbrini, 2015, Metabolically normal obese people are protected from adverse effects following weight gain, J. Clin. Investig., 125, 787, 10.1172/JCI78425
Kashyap, 2003, A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes, Diabetes, 52, 2461, 10.2337/diabetes.52.10.2461
Lupi, 2002, Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated, Diabetes, 51, 1437, 10.2337/diabetes.51.5.1437
Marques, 1998, Association of fat cell size and paracrine growth factors in development of hyperplastic obesity, Am. J. Physiol., 275, R1898
Thorne, 2010, Increased visceral adipocyte lipolysis—A pathogenic role in nonalcoholic fatty liver disease?, J. Clin. Endocrinol. Metab., 95, E209, 10.1210/jc.2010-0520
Jensen, 1989, Influence of body fat distribution on free fatty acid metabolism in obesity, J. Clin. Investig., 83, 1168, 10.1172/JCI113997
Ye, 2013, Adiponectin, driver or passenger on the road to insulin sensitivity?, Mol. Metab., 2, 133, 10.1016/j.molmet.2013.04.001
Arner, 2010, Adipocyte turnover: Relevance to human adipose tissue morphology, Diabetes, 59, 105, 10.2337/db09-0942
Sainz, 2015, Leptin resistance and diet-induced obesity: Central and peripheral actions of leptin, Metabolism, 64, 35, 10.1016/j.metabol.2014.10.015
Skurk, 2007, Relationship between adipocyte size and adipokine expression and secretion, J. Clin. Endocrinol. Metab., 92, 1023, 10.1210/jc.2006-1055
Vargas, 2013, Heterogeneity in subcutaneous adipose tissue morphology and metabolic complications in overweight and obese women, Metab. Syndr. Relat. Disord., 11, 276, 10.1089/met.2013.0024
Alligier, 2013, Visceral fat accumulation during lipid overfeeding is related to subcutaneous adipose tissue characteristics in healthy men, J. Clin. Endocrinol. Metab., 98, 802, 10.1210/jc.2012-3289
Dixit, 2014, Metabolically healthy and unhealthy obese—The 2013 stock conference report, Obes. Rev., 15, 697, 10.1111/obr.12199
McLaughlin, 2014, Subcutaneous adipose cell size and distribution: Relationship to insulin resistance and body fat, Obesity, 22, 673, 10.1002/oby.20209
Johannsen, 2014, Effect of 8 weeks of overfeeding on ectopic fat deposition and insulin sensitivity: Testing the "adipose tissue expandability" hypothesis, Diabetes Care, 37, 2789, 10.2337/dc14-0761
McLaughlin, 2007, Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals: Effect of differences in insulin sensitivity, Arch. Intern. Med., 167, 642, 10.1001/archinte.167.7.642
Scherer, 2006, Adipose tissue: From lipid storage compartment to endocrine organ, Diabetes, 55, 1537, 10.2337/db06-0263
Arner, 2011, Genetic predisposition for type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis, PLoS ONE, 6, e18284, 10.1371/journal.pone.0018284
Arner, 2003, The adipocyte in insulin resistance: Key molecules and the impact of the thiazolidinediones, Trends Endocrinol. Metab., 14, 137, 10.1016/S1043-2760(03)00024-9
Kanda, 2006, Mcp-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity, J. Clin. Investig., 116, 1494, 10.1172/JCI26498
Bohm, 2014, Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals, PLoS ONE, 9, e93148, 10.1371/journal.pone.0093148
Sidossis, 1996, Glucose and insulin-induced inhibition of fatty acid oxidation: The glucose-fatty acid cycle reversed, Am. J. Physiol., 270, E733
Ricchi, 2009, Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes, J. Gastroenterol Hepatol., 24, 830, 10.1111/j.1440-1746.2008.05733.x
Siriwardhana, 2013, Modulation of adipose tissue inflammation by bioactive food compounds, J. Nutr. Biochem., 24, 613, 10.1016/j.jnutbio.2012.12.013
Zhao, 2005, Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells, Biochem. Biophys. Res. Commun., 336, 909, 10.1016/j.bbrc.2005.08.204
Calder, 2006, Polyunsaturated fatty acids and inflammation, Prostaglandins Leukot. Essent. Fatty Acids., 75, 197, 10.1016/j.plefa.2006.05.012
Mei, 2011, Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes, J. Pharmacol. Exp. Ther., 339, 487, 10.1124/jpet.111.184341
Haus, 2009, Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance, Diabetes, 58, 337, 10.2337/db08-1228
Kang, 2005, The effects of polyunsaturated:Saturated fatty acids ratios and peroxidisability index values of dietary fats on serum lipid profiles and hepatic enzyme activities in rats, Br. J. Nutr., 94, 526, 10.1079/BJN20051523
Liao, 2010, Effects of different ratios of monounsaturated and polyunsaturated fatty acids to saturated fatty acids on regulating body fat deposition in hamsters, Nutrition, 26, 811, 10.1016/j.nut.2009.09.009
Summers, 2002, Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity, Diabetologia, 45, 369, 10.1007/s00125-001-0768-3
Hudgins, 1996, Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet, J. Clin. Investig., 97, 2081, 10.1172/JCI118645
Chong, 2008, Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding, Am. J. Clin. Nutr., 87, 817, 10.1093/ajcn/87.4.817
Flowers, 2009, The Delta9 fatty acid desaturation index as a predictor of metabolic disease, Clin. Chem., 55, 2071, 10.1373/clinchem.2009.135152
Warensjo, 2009, Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: Links to obesity and insulin resistance, Lipids Health. Dis., 8, 37, 10.1186/1476-511X-8-37
Miyazaki, 2008, Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia, Arterioscler. Thromb. Vasc. Biol., 28, 1193, 10.1161/ATVBAHA.107.160150
Riserus, 2005, Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: Link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma, Diabetes, 54, 1379, 10.2337/diabetes.54.5.1379
Peter, 2009, Hepatic lipid composition and stearoyl-coenzyme a desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios, Clin. Chem., 55, 2113, 10.1373/clinchem.2009.127274
Attie, 2002, Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia, J. Lipid Res., 43, 1899, 10.1194/jlr.M200189-JLR200
DeFronzo, 2010, Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: The missing links. The claude bernard lecture 2009, Diabetologia, 53, 1270, 10.1007/s00125-010-1684-1
Belfort, 2005, Dose-response effect of elevated plasma free fatty acid on insulin signaling, Diabetes, 54, 1640, 10.2337/diabetes.54.6.1640
Chinen, 2007, Vascular lipotoxicity: Endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese zucker diabetic fatty rats, Endocrinology, 148, 160, 10.1210/en.2006-1132
Inoguchi, 2000, High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C—Dependent activation of NAD(P)H oxidase in cultured vascular cells, Diabetes, 49, 1939, 10.2337/diabetes.49.11.1939
Watanabe, 2005, Inhibition of the renin-angiotensin system prevents free fatty acid-induced acute endothelial dysfunction in humans, Arterioscler Thromb. Vasc. Biol., 25, 2376, 10.1161/01.ATV.0000187465.55507.85
Egan, 1996, Obesity hypertension is related more to insulin's fatty acid than glucose action, Hypertension, 27, 723, 10.1161/01.HYP.27.3.723
DeFronzo, 2009, Skeletal muscle insulin resistance is the primary defect in type 2 diabetes, Diabetes Care, 32, S157, 10.2337/dc09-S302
Perseghin, 1999, Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: A 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents, Diabetes, 48, 1600, 10.2337/diabetes.48.8.1600
Szendroedi, 2008, Mitochondrial fitness and insulin sensitivity in humans, Diabetologia, 51, 2155, 10.1007/s00125-008-1153-2
Jensen, 2008, Role of body fat distribution and the metabolic complications of obesity, J. Clin. Endocrinol. Metab., 93, S57, 10.1210/jc.2008-1585
Rahman, 2013, Primary hepatocellular carcinoma and metabolic syndrome: An update, World J. Gastrointest Oncol., 5, 186, 10.4251/wjgo.v5.i9.186
Marra, 2008, Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis, Trends Mol. Med., 14, 72, 10.1016/j.molmed.2007.12.003
Park, 2015, Global patterns of hepatocellular carcinoma management from diagnosis to death: The bridge study, Liver Int., 35, 2155, 10.1111/liv.12818
Agostinelli, 2014, HCC development is associated to peripheral insulin resistance in a mouse model of NASH, PLoS ONE, 9, e97136, 10.1371/journal.pone.0097136
Chalasani, 2012, The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American association for the study of liver diseases, American college of gastroenterology, and the American gastroenterological association, Hepatology, 55, 2005, 10.1002/hep.25762
Ertle, 2011, Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis, Int. J. Cancer, 128, 2436, 10.1002/ijc.25797
Dongiovanni, 2014, Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors, World J. Gastroenterol., 20, 12945, 10.3748/wjg.v20.i36.12945
Wong, 2014, Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S, Hepatology, 59, 2188, 10.1002/hep.26986
Basta, 2011, What is the role of the receptor for advanced glycation end products-ligand axis in liver injury?, Liver Transpl., 17, 633, 10.1002/lt.22306
Kasumov, 2015, Ceramide as a mediator of non-alcoholic fatty liver disease and associated atherosclerosis, PLoS ONE, 10, e0126910, 10.1371/journal.pone.0126910
Lomonaco, 2012, Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with non-alcoholic fatty liver disease, Hepatology, 55, 1389, 10.1002/hep.25539
Sommerfeld, 2015, Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis, J. Biol. Chem., 290, 4398, 10.1074/jbc.M114.617035
Clarke, 2014, Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease, Dig. Dis. Sci., 59, 365, 10.1007/s10620-013-2873-9
Muir, 2013, Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma, Cancer Res., 73, 4722, 10.1158/0008-5472.CAN-12-3797
Sironi, 2012, Impact of increased visceral and cardiac fat on cardiometabolic risk and disease, Diabet Med., 29, 622, 10.1111/j.1464-5491.2011.03503.x
Djaberi, 2008, Relation of epicardial adipose tissue to coronary atherosclerosis, Am. J. Cardiol., 102, 1602, 10.1016/j.amjcard.2008.08.010
Ding, 2008, The association of pericardial fat with calcified coronary plaque, Obesity, 16, 1914, 10.1038/oby.2008.278
Floegel, 2013, Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach, Diabetes, 62, 639, 10.2337/db12-0495
Yu, 2012, Novel biomarkers for pre-diabetes identified by metabolomics, Mol. Syst. Biol., 8, 615, 10.1038/msb.2012.43
Ferrannini, 2013, Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance, Diabetes, 62, 1730, 10.2337/db12-0707
Rhee, 2011, Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans, J. Clin. Investig., 121, 1402, 10.1172/JCI44442
Cofan, 2011, Inverse association between serum phospholipid oleic acid and insulin resistance in subjects with primary dyslipidaemia, Clin. Nutr., 30, 590, 10.1016/j.clnu.2011.02.008
Hodge, 2007, Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: Interpreting the role of linoleic acid, Am. J. Clin. Nutr., 86, 189, 10.1093/ajcn/86.1.189
Nestel, 2014, Specific plasma lipid classes and phospholipid fatty acids indicative of dairy food consumption associate with insulin sensitivity, Am. J. Clin. Nutr., 99, 46, 10.3945/ajcn.113.071712
Fox, 2011, Circulating sphingolipid biomarkers in models of type 1 diabetes, J. Lipid Res., 52, 509, 10.1194/jlr.M010595
Kang, 2013, Sphingolipid metabolism and obesity-induced inflammation, Front. Endocrinol., 4, 67, 10.3389/fendo.2013.00067
Samad, 2006, Altered adipose and plasma sphingolipid metabolism in obesity: A potential mechanism for cardiovascular and metabolic risk, Diabetes, 55, 2579, 10.2337/db06-0330
Jornayvaz, 2012, Diacylglycerol activation of protein kinase cepsilon and hepatic insulin resistance, Cell Metab., 15, 574, 10.1016/j.cmet.2012.03.005
Kotronen, 2009, Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver, Diabetes, 58, 203, 10.2337/db08-1074
Magkos, 2012, Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects, Gastroenterology, 142, 1444, 10.1053/j.gastro.2012.03.003
Gorden, 2011, Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model, PLoS ONE, 6, e22775, 10.1371/journal.pone.0022775