Superfamily thụ thể steroid và hormone tuyến giáp

American Association for the Advancement of Science (AAAS) - Tập 240 Số 4854 - Trang 889-895 - 1988
Ronald M. Evans1
1Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92138-9216.

Tóm tắt

Phân tích các thụ thể steroid rất quan trọng để hiểu rõ các chi tiết phân tử của việc kiểm soát phiên mã, cũng như cung cấp cái nhìn về cách mà một yếu tố giao dịch cá nhân góp phần vào danh tính và chức năng tế bào. Những nghiên cứu này đã dẫn đến việc phát hiện ra một siêu họ protein điều hòa bao gồm các thụ thể cho hormone tuyến giáp và morphogen vertebrate axit retinoic. Mặc dù động vật sử dụng các cách phức tạp và thường khác biệt để kiểm soát sinh lý và phát triển của chúng, việc phát hiện các phân tử liên quan đến thụ thể trong một loạt các loài cho thấy rằng các cơ chế nằm sau sự hình thành hình thể và cân bằng nội môi có thể phổ biến hơn những gì trước đây chúng ta mong đợi.

Từ khóa


Tài liệu tham khảo

ADDISON T CONSTITUTIONAL LOCAL (1855).

10.1126/science.3037703

Ashburner, M., Nature 285:435 (1980).

Baker, A., Proc. Natl. Acad. Sci. U.S.A. 85: 3294 (1988).

BANERJI, J, A LYMPHOCYTE-SPECIFIC CELLULAR ENHANCER IS LOCATED DOWNSTREAM OF THE JOINING REGION IN IMMUNOGLOBULIN HEAVY-CHAIN GENES, CELL 33: 729 (1983).

BAXTER, J.D., ENDOCRINOL METAB: 385 (1981).

BECKER, P.B., NATURE 324: 606 (1986).

BENOIST, C, INVIVO SEQUENCE REQUIREMENTS OF THE SV40 EARLY PROMOTER REGION, NATURE 290: 304 (1981).

BENTLEY, P.J., COMP VERTEBRATE ENDO: 65 (1986).

BRENT, R, A EUKARYOTIC TRANSCRIPTIONAL ACTIVATOR BEARING THE DNA SPECIFICITY OF A PROKARYOTIC REPRESSOR, CELL 43: 729 (1985).

BROWN, M.S., PHARMACOL BASIS THER: 827 (1985).

CARLSTEDTDUKE, J, IMMUNOCHEMICAL ANALYSIS OF THE GLUCOCORTICOID RECEPTOR - IDENTIFICATION OF A 3RD DOMAIN SEPARATE FROM THE STEROID-BINDING AND DNA-BINDING DOMAINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 4260 (1982).

CATO, ACB, THE HORMONE REGULATORY ELEMENT OF MOUSE MAMMARY-TUMOR VIRUS MEDIATES PROGESTERONE INDUCTION, EMBO JOURNAL 5: 2237 (1986).

Science 238:788 (1987).

CHAMBON, P, PROMOTER ELEMENTS OF GENES-CODING FOR PROTEINS AND MODULATION OF TRANSCRIPTION BY ESTROGENS AND PROGESTERONE, RECENT PROGRESS IN HORMONE RESEARCH 40: 1 (1984).

CHANDLER, V.L., DNA-SEQUENCES BOUND SPECIFICALLY BY GLUCOCORTICOID RECEPTOR INVITRO RENDER A HETEROLOGOUS PROMOTER HORMONE RESPONSIVE INVIVO, CELL 33: 489 (1983).

Compton, J. G., Proceedings of the National Academy of Sciences of the United States of America 80: 16 (1983).

CONNEELY, O.M., SEQUENCE AND EXPRESSION OF A FUNCTIONAL CHICKEN PROGESTERONE-RECEPTOR, MOLECULAR ENDOCRINOLOGY 1: 517 (1987).

DANIELSEN, M, THE MOUSE GLUCOCORTICOID RECEPTOR - MAPPING OF FUNCTIONAL DOMAINS BY CLONING, SEQUENCING AND EXPRESSION OF WILD-TYPE AND MUTANT RECEPTOR PROTEINS, EMBO JOURNAL 5: 2513 (1986).

DANIELSEN, M, DOMAINS OF THE GLUCOCORTICOID RECEPTOR INVOLVED IN SPECIFIC AND NONSPECIFIC DEOXYRIBONUCLEIC-ACID BINDING, HORMONE ACTIVATION, AND TRANSCRIPTIONAL ENHANCEMENT, MOLECULAR ENDOCRINOLOGY 1: 816 (1987).

10.1126/science.6328658

DEJEAN, A, HEPATITIS-B VIRUS-DNA INTEGRATION IN A SEQUENCE HOMOLOGOUS TO V-ERB-A AND STEROID-RECEPTOR GENES IN A HEPATOCELLULAR-CARCINOMA, NATURE 322: 70 (1986).

DELLWEG, H.G., ACTIVE DOMAINS IN WILD-TYPE AND MUTANT GLUCOCORTICOID RECEPTORS, EMBO JOURNAL 1: 285 (1982).

DETHE, H, A NOVEL STEROID THYROID-HORMONE RECEPTOR-RELATED GENE INAPPROPRIATELY EXPRESSED IN HUMAN HEPATOCELLULAR-CARCINOMA, NATURE 330: 667 (1987).

DRUEGE, P.M., INTRODUCTION OF ESTROGEN-RESPONSIVENESS INTO MAMMALIAN-CELL LINES, NUCLEIC ACIDS RESEARCH 14: 9329 (1986).

ELKIN, W, MEMOIRS OF THE SOCIETY FOR ENDOCRINOLOGY 18: 137 (1970).

EVANS, R.M., ZINC FINGERS - GILT BY ASSOCIATION, CELL 52: 1 (1988).

EVANS, R.M., GLUCOCORTICOID AND THYROID-HORMONES TRANSCRIPTIONALLY REGULATE GROWTH-HORMONE GENE-EXPRESSION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 7659 (1982).

GAUNT, R, HDB PHYSL ENDOCRINOL 6: 1 (1975).

10.1016/0092-8674(86)90339-9

GIGUERE, V, IDENTIFICATION OF A RECEPTOR FOR THE MORPHOGEN RETINOIC ACID, NATURE 330: 624 (1987).

GIGUERE, V, IDENTIFICATION OF A NEW CLASS OF STEROID-HORMONE RECEPTORS, NATURE 331: 91 (1988).

GINIGER, E, TRANSCRIPTION IN YEAST ACTIVATED BY A PUTATIVE AMPHIPATHIC ALPHA-HELIX LINKED TO A DNA-BINDING UNIT, NATURE 330: 670 (1987).

GLASS, C.K., A C-ERB-A BINDING-SITE IN RAT GROWTH-HORMONE GENE MEDIATES TRANSACTIVATION BY THYROID-HORMONE, NATURE 329: 738 (1987).

10.1038/325365a0

GOVINDAN, M.V., PURIFIED GLUCOCORTICOID RECEPTOR-HORMONE COMPLEX FROM RAT-LIVER CYTOSOL BINDS SPECIFICALLY TO CLONED MOUSE MAMMARY-TUMOR VIRUS LONG TERMINAL REPEATS INVITRO, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 5157 (1982).

10.1038/325075a0

10.1126/science.3753802

GRONEMEYER, H, THE CHICKEN PROGESTERONE-RECEPTOR - SEQUENCE, EXPRESSION AND FUNCTIONAL-ANALYSIS, EMBO JOURNAL 6: 3985 (1987).

GUDERNATSCH, J.F., Feeding Experiments on tadpoles. I. The intlnence of specific organs given as food on growth and differentiation. A contribution to the knowledge of organs with internal secretion., ARCHIV FUR ENTWICKLUNGSMECHANIK DER ORGANISMEN 35: 457 (1912).

HAGER, L.J., TRANSCRIPTIONAL REGULATION OF MOUSE-LIVER METALLOTHIONEIN-I GENE BY GLUCOCORTICOIDS, NATURE 291: 340 (1981).

HOLLENBERG, S.M., COLOCALIZATION OF DNA-BINDING AND TRANSCRIPTIONAL ACTIVATION FUNCTIONS IN THE HUMAN GLUCOCORTICOID RECEPTOR, CELL 49: 39 (1987).

HOLLENBERG S unpublished data.

HOLLENBERG, S.M., PRIMARY STRUCTURE AND EXPRESSION OF A FUNCTIONAL HUMAN GLUCOCORTICOID RECEPTOR CDNA, NATURE 318: 635 (1985).

HOPE, I.A., FUNCTIONAL DISSECTION OF A EUKARYOTIC TRANSCRIPTIONAL ACTIVATOR PROTEIN, GCN4 OF YEAST, CELL 46: 885 (1986).

HUCKABY, C.S., STRUCTURE OF THE CHROMOSOMAL CHICKEN PROGESTERONE-RECEPTOR GENE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 8380 (1987).

Huxley, J. S., Nature 123:712 (1929).

IVARIE, R.D., GLUCOCORTICOID DOMAIN - STEROID-MEDIATED CHANGES IN RATE OF SYNTHESIS OF RAT HEPATOMA PROTEINS, CELL 13: 41 (1978).

JANTZEN, H.M., COOPERATIVITY OF GLUCOCORTICOID RESPONSE ELEMENTS LOCATED FAR UPSTREAM OF THE TYROSINE AMINOTRANSFERASE GENE, CELL 49: 29 (1987).

JENSEN, E.V., MECHANISM OF ACTION OF FEMALE SEX-HORMONES, ANNUAL REVIEW OF BIOCHEMISTRY 41: 203 (1972).

JETTEN, A.M., STIMULATION OF DIFFERENTIATION OF SEVERAL MURINE EMBRYONAL CARCINOMA CELL-LINES BY RETINOIC ACID, EXPERIMENTAL CELL RESEARCH 124: 381 (1979).

JOHNSON, M.S., A METHOD FOR THE SIMULTANEOUS ALIGNMENT OF 3 OR MORE AMINO-ACID-SEQUENCES, JOURNAL OF MOLECULAR EVOLUTION 23: 267 (1986).

KARIN, M, METALLOTHIONEIN MESSENGER-RNA INDUCTION IN HELA-CELLS IN RESPONSE TO ZINC OR DEXAMETHASONE IS A PRIMARY INDUCTION RESPONSE, NATURE 286: 295 (1980).

KARIN, M, CHARACTERIZATION OF DNA-SEQUENCES THROUGH WHICH CADMIUM AND GLUCOCORTICOID HORMONES INDUCE HUMAN METALLOTHIONEIN-IIA GENE, NATURE 308: 513 (1984).

10.1126/science.3080805

KENDALL, E.C., The isolation in crystalline form for the compound containing iodin, which occurs in the thyroid - Its chemical nature and physiologic activity, JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 64: 2042 (1915).

KLEINHITPASS, L, AN ESTROGEN-RESPONSIVE ELEMENT DERIVED FROM THE 5' FLANKING REGION OF THE XENOPUS VITELLOGENIN A2 GENE FUNCTIONS IN TRANSFECTED HUMAN-CELLS, CELL 46: 1053 (1986).

KRIEGER, D, ENDOCRINOLOGY METABO: 125 (1981).

10.1002/j.1460-2075.1986.tb04300.x

KUMAR, V, FUNCTIONAL DOMAINS OF THE HUMAN ESTROGEN-RECEPTOR, CELL 51: 941 (1987).

KUMAR, V, LOCALIZATION OF THE ESTRADIOL-BINDING AND PUTATIVE DNA-BINDING DOMAINS OF THE HUMAN ESTROGEN-RECEPTOR, EMBO JOURNAL 5: 2231 (1986).

KURTZ, D.T., MULTI-HORMONAL INDUCTION OF HEPATIC ALPHA-2U-GLOBULIN MESSENGER-RNA AS MEASURED BY HYBRIDIZATION TO COMPLEMENTARY-DNA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 4791 (1977).

LAIMINS, L.A., HOST-SPECIFIC ACTIVATION OF TRANSCRIPTION BY TANDEM REPEATS FROM SIMIAN VIRUS-40 AND MOLONEY MURINE SARCOMA-VIRUS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 6453 (1982).

LAW, M.L., THE PROGESTERONE-RECEPTOR GENE MAPS TO HUMAN-CHROMOSOME BAND-11Q13, THE SITE OF THE MAMMARY ONCOGENE-INT-2, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 2877 (1987).

LOOSFELT, H, CLONING AND SEQUENCE-ANALYSIS OF RABBIT PROGESTERONE-RECEPTOR COMPLEMENTARY-DNA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 9045 (1986).

Mattei M. Human Genetics in press.

MAURER R COMMUNICATION.

10.1126/science.3029866

MIESFELD, R, GENETIC COMPLEMENTATION OF A GLUCOCORTICOID RECEPTOR DEFICIENCY BY EXPRESSION OF CLONED RECEPTOR CDNA, CELL 46: 389 (1986).

10.1002/j.1460-2075.1985.tb03825.x

MISRAHI, M, COMPLETE AMINO-ACID-SEQUENCE OF THE HUMAN PROGESTERONE-RECEPTOR DEDUCED FROM CLONED CDNA, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 143: 740 (1987).

MORGAN, T.H., NOBEL LECTURES MOL B: 3 (1977).

MORGAN T.H. THEORY GENE (1926).

NEEDHAM J SCI CIVILISATION CHI (1983).

OKRET, S, CHARACTERIZATION OF AN ANTISERUM AGAINST THE GLUCOCORTICOID RECEPTOR, BIOCHIMICA ET BIOPHYSICA ACTA 677: 205 (1981).

OMALLEY B COMMUNICATION.

OSTROWSKI, M.C., MODULATION OF ENHANCER ACTIVITY BY THE HORMONE RESPONSIVE REGULATORY ELEMENT FROM MOUSE MAMMARY-TUMOR VIRUS, EMBO JOURNAL 3: 1891 (1984).

PARKS, W.P., DEXAMETHASONE STIMULATION OF MURINE MAMMARY-TUMOR VIRUS EXPRESSION - TISSUE-CULTURE SOURCE OF VIRUS, SCIENCE 184: 158 (1974).

PAYVAR, F, SEQUENCE-SPECIFIC BINDING OF GLUCOCORTICOID RECEPTOR TO MTV DNA AT SITES WITHIN AND UPSTREAM OF THE TRANSCRIBED REGION, CELL 35: 381 (1983).

PETKOVICH, M, A HUMAN RETINOIC ACID RECEPTOR WHICH BELONGS TO THE FAMILY OF NUCLEAR RECEPTORS, NATURE 330: 444 (1987).

PFAHL, M, SPECIFIC BINDING OF THE GLUCOCORTICOID-RECEPTOR COMPLEX TO THE MOUSE MAMMARY-TUMOR PROVIRAL PROMOTER REGION, CELL 31: 475 (1982).

POLAND, A, STEREOSPECIFIC, HIGH AFFINITY BINDING OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN BY HEPATIC CYTOSOL - EVIDENCE THAT BINDING SPECIES IS RECEPTOR FOR INDUCTION OF ARYL-HYDROCARBON HYDROXYLASE, JOURNAL OF BIOLOGICAL CHEMISTRY 251: 4936 (1976).

PTASHNE M GENETIC SWITCH (1986).

RINGOLD, G.M., STEROID-HORMONE REGULATION OF GENE-EXPRESSION, ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 25: 529 (1985).

RINGOLD, G.M., DEXAMETHASONE-MEDIATED INDUCTION OF MOUSE MAMMARY-TUMOR VIRUS-RNA - A SYSTEM FOR STUDYING GLUCOCORTICOID ACTION, CELL 6: 299 (1975).

ROBERTSON, M, RETINOIC ACID RECEPTOR - TOWARDS A BIOCHEMISTRY OF MORPHOGENESIS, NATURE 330: 420 (1987).

ROBINS, D.M., REGULATED EXPRESSION OF HUMAN GROWTH-HORMONE GENES IN MOUSE CELLS, CELL 29: 623 (1982).

RUSCONI, S, FUNCTIONAL DISSECTION OF THE HORMONE AND DNA-BINDING ACTIVITIES OF THE GLUCOCORTICOID RECEPTOR, EMBO JOURNAL 6: 1309 (1987).

SABBAH, M, THE BINDING-ACTIVITY OF ESTROGEN-RECEPTOR TO DNA AND HEAT-SHOCK PROTEIN (MR 90,000) IS DEPENDENT ON RECEPTOR-BOUND METAL, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 8631 (1987).

10.1038/324635a0

SAPOLSKY, R.M., GLUCOCORTICOID TOXICITY IN THE HIPPOCAMPUS - REVERSAL BY SUPPLEMENTATION WITH BRAIN FUELS, JOURNAL OF NEUROSCIENCE 6: 2240 (1986).

SCHEIDEREIT, C, THE GLUCOCORTICOID RECEPTOR BINDS TO DEFINED NUCLEOTIDE-SEQUENCES NEAR THE PROMOTER OF MOUSE MAMMARY-TUMOR VIRUS, NATURE 304: 749 (1983).

SEGRAVES W THESIS STANFORD U (1988).

SLATER, E.P., GLUCOCORTICOID RECEPTOR-BINDING AND ACTIVATION OF A HETEROLOGOUS PROMOTER BY DEXAMETHASONE BY THE 1ST INTRON OF THE HUMAN GROWTH-HORMONE GENE, MOLECULAR AND CELLULAR BIOLOGY 5: 2984 (1985).

SLEDGE, G.W., STEROID-HORMONE RECEPTORS IN HUMAN-BREAST CANCER, ADVANCES IN CANCER RESEARCH 38: 61 (1983).

SPINDLER, S.R., GROWTH-HORMONE GENE-TRANSCRIPTION IS REGULATED BY THYROID AND GLUCOCORTICOID HORMONES IN CULTURED RAT PITUITARY-TUMOR CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 11627 (1982).

STRICKLAND, S, INDUCTION OF DIFFERENTIATION IN TERATOCARCINOMA STEM-CELLS BY RETINOIC ACID, CELL 15: 393 (1978).

SUDHOF, J, CELL 48: 1061 (1987).

TATA, J, J CLIN ENDOCRINOL ME 35: 330 (1972).

THALLER, C, IDENTIFICATION AND SPATIAL-DISTRIBUTION OF RETINOIDS IN THE DEVELOPING CHICK LIMB BUD, NATURE 327: 625 (1987).

THOMPSON C unpublished data.

10.1126/science.3629259

TOMPKINS G.M. HARVEY LECTURES 68 (1974).

TROEN, P, ENDOCRINOLOGY METABO: 963 (1981).

VONDERAHE, D, GLUCOCORTICOID AND PROGESTERONE RECEPTORS BIND TO THE SAME SITES IN 2 HORMONALLY REGULATED PROMOTERS, NATURE 313: 706 (1985).

WANG, S.Y., MOLECULAR-CLONING OF GENE-SEQUENCES TRANSCRIPTIONALLY REGULATED BY RETINOIC ACID AND DIBUTYRYL CYCLIC-AMP IN CULTURED MOUSE TERATOCARCINOMA CELLS, DEVELOPMENTAL BIOLOGY 107: 75 (1985).

WATERMAN, M.L., A SINGLE DOMAIN OF THE ESTROGEN-RECEPTOR CONFERS DEOXYRIBONUCLEIC-ACID BINDING AND TRANSCRIPTIONAL ACTIVATION OF THE RAT PROLACTIN GENE, MOLECULAR ENDOCRINOLOGY 2: 14 (1988).

WEILER, I.J., THE XENOPUS-LAEVIS ESTROGEN-RECEPTOR - SEQUENCE HOMOLOGY WITH HUMAN AND AVIAN RECEPTORS AND IDENTIFICATION OF MULTIPLE ESTROGEN-RECEPTOR MESSENGER RIBONUCLEIC-ACIDS, MOLECULAR ENDOCRINOLOGY 1: 355 (1987).

WEINBERGER, C, DOMAIN-STRUCTURE OF HUMAN GLUCOCORTICOID RECEPTOR AND ITS RELATIONSHIP TO THE V-ERB-A ONCOGENE PRODUCT, NATURE 318: 670 (1985).

10.1038/324641a0

WELLMAN, T, NATURE 324: 688 (1986).

WRANGE, O, PURIFICATION OF THE GLUCOCORTICOID RECEPTOR FROM RAT-LIVER CYTOSOL, JOURNAL OF BIOLOGICAL CHEMISTRY 254: 9284 (1979).

WRANGE, O, CHARACTERIZATION OF THE PURIFIED ACTIVATED GLUCOCORTICOID RECEPTOR FROM RAT-LIVER CYTOSOL, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 4534 (1984).

WRANGE, O, SEPARATION OF HORMONE-BINDING AND DNA-BINDING SITES OF HEPATIC GLUCOCORTICOID RECEPTOR BY MEANS OF PROTEOLYSIS, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 856 (1978).

YAMAMOTO, K.R., STEROID-RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS, ANNUAL REVIEW OF GENETICS 19: 209 (1985).

YAMAMOTO, K.R., RECENT PROGRESS IN HORMONE RESEARCH 32: 3 (1976).