The Sterile Inflammatory Response

Annual Review of Immunology - Tập 28 Số 1 - Trang 321-342 - 2010
Kenneth L. Rock1, Eicke Latz2, Fernando Ontiveros3, Hajime Kono3
1Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA. [email protected]
2Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01655;
3Department of Pathology and, University of Massachusetts Medical School, Worcester, Massachusetts 01655

Tóm tắt

The acute inflammatory response is a double-edged sword. On the one hand, it plays a key role in initial host defense, particularly against many infections. On the other hand, its aim is imprecise, and as a consequence, when it is drawn into battle, it can cause collateral damage in tissues. In situations where the inciting stimulus is sterile, the cost-benefit ratio may be high; because of this, sterile inflammation underlies the pathogenesis of a number of diseases. Although there have been major advances in our understanding of how microbes trigger inflammation, much less has been learned about this process in sterile situations. This review focuses on a subset of the many sterile stimuli that can induce inflammation—specifically dead cells and a variety of irritant particles, including crystals, minerals, and protein aggregates. Although this subset of stimuli is structurally very diverse and might appear to be unrelated, there is accumulating evidence that the innate immune system may recognize them in similar ways and stimulate the sterile inflammatory response via common pathways. Here we review established and emerging data about these responses.

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Annual Review of Immunology

Tập 28 Số 1

321-342

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