The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T‐Cell Subsets in Humans

Oxidative Medicine and Cellular Longevity - Tập 2017 Số 1 - 2017
J. Luis Espinoza1, Ly Quoc Trung1,2, Pleiades Tiharu Inaoka3, Kayoko Yamada1, Dao T. T. An1, Shohei Mizuno4, Shinji Nakao1, Akiyoshi Takami4
1Department of Hematology and Oncology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
2Phuong Chau International Hospital, Can Tho, Vietnam
3Department of Physical Therapy, School of Health Sciences, Kanazawa University, Kanazawa, Japan
4Department of Internal Medicine, Division of Hematology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

Tóm tắt

Preclinical studies have shown that resveratrol exerts immunomodulatory effects with potential clinical value in the amelioration of autoimmune disorders and cancer prevention; however, little is known about the in vivo effects of this naturally occurring polyphenol on human immune cells. We assessed the effects of repeated doses of resveratrol (1000 mg/day for 28 days) on circulating immune cells in healthy Japanese individuals. Resveratrol was safe and well tolerated and was associated with significant increases in the numbers of circulating γδ T cells and regulatory T cells and resulted in small, yet significant, decreases in the plasma levels of the proinflammatory cytokines TNF‐α and MCP‐1 and a significant increase in the plasma antioxidant activity compared with the corresponding antioxidant baseline activity and with that in four control individuals. In in vitro studies, resveratrol significantly improved the growth of γδ T cells and regulatory T cells. These findings demonstrate that resveratrol has some clear biological effects on human circulating immune cells. Further studies are necessary to interpret the long‐term immunological changes associated with resveratrol treatment.

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Oxidative Medicine and Cellular Longevity

Tập 2017 Số 1

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