The Phosphoinositide 3-Kinase Pathway

American Association for the Advancement of Science (AAAS) - Tập 296 Số 5573 - Trang 1655-1657 - 2002
Lewis C. Cantley1
1Department of Cell Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115–5713, USA.

Tóm tắt

Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.

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Tài liệu tham khảo

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Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 296 Số 5573

1655-1657

Thông tin tác giả