The Pharmacokinetics of Escitalopram After Oral and Intravenous Administration of Single and Multiple Doses to Healthy Subjects

Journal of Clinical Pharmacology - Tập 45 Số 12 - Trang 1400-1406 - 2005
Birgitte Søgaard1, H. Mengel1, Niranjan Rao2, Frank Larsen1
1Department of Clinical Pharmacology and Pharmacokinetics, H. Lundbeck A/S, Copenhagen, Denmark
2Forest Research Institute, Forest Laboratories, Inc, Jersey City, New Jersey (N. Rao)

Tóm tắt

The pharmacokinetics of escitalopram (S‐citalopram) and its principal metabolite, S‐demethylcitalopram (S‐DCT), were investigated after intravenous and oral administration to healthy subjects. After intravenous infusion of escitalopram, the mean systemic clearance and volume of distribution were 31 L/h and 1100 L, respectively. After oral administration of single or multiple doses, the absorption was relatively fast, with the maximum observed plasma or serum concentration (Cmax) attained after 3 to 4 hours. The mean half‐lives were 27 and 33 hours, respectively; steady state was attained within 10 days. The area under the plasma or serum concentration‐time curve from time zero to 24 hours and Cmax was both linear and proportional to the dose. The apparent volume of distribution was around 20 L/kg. Comparison of the systemic and oral clearance implied a high absolute bioavailability. There was no evidence of interconversion from S‐citalopram to R‐citalopram either in plasma or in urine. Concurrent intake of food had no effect on the pharmacokinetics of escitalopram or its metabolite. All treatments were well tolerated.

Từ khóa


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Thông tin
Thông tin xuất bản

Journal of Clinical Pharmacology

Tập 45 Số 12

1400-1406

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