The Pathology of Influenza Virus Infections

Annual Review of Pathology: Mechanisms of Disease - Tập 3 Số 1 - Trang 499-522 - 2008
Jeffery K. Taubenberger1, David M. Morens1
1National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892

Tóm tắt

Influenza viruses are significant human respiratory pathogens that cause both seasonal, endemic infections and periodic, unpredictable pandemics. The worst pandemic on record, in 1918, killed approximately 50 million people worldwide. Human infections caused by H5N1 highly pathogenic avian influenza viruses have raised concern about the emergence of another pandemic. The histopathology of fatal influenza virus pneumonias as documented over the past 120 years is reviewed here. Strikingly, the spectrum of pathologic changes described in the 1918 influenza pandemic is not significantly different from the histopathology observed in other less lethal pandemics or even in deaths occurring during seasonal influenza outbreaks.

Từ khóa


Tài liệu tham khảo

1. Mulder J, Hers JFP. 1972.Influenza. Groningen: Wolters-Noordhoff. 287 pp.

Wright PF, 2007, Fields Virology, 1691

Hirsch A, 1883, Handbook of Geographical and Historical Pathology

10.1001/jama.289.2.179

10.1146/annurev.med.51.1.407

10.3201/eid1209.05-0979

Beveridge W, 1977, Influenza: The Last Great Plague, an Unfinished Story

Simonsen L, 1999, Vaccine, 17, S

10.1086/511989

10.1353/bhm.2002.0022

10.1111/j.1445-5994.1974.tb03140.x

10.1086/505122

10.1309/HV74-N24T-2K2C-3E8Q

10.1001/jama.1919.02610090034009

Leichtenstern O, 1896, Nothnagel's Spezielle Pathologie und Therapie, 1

10.1001/jama.1970.03180100019004

10.1172/JCI103791

10.1001/archinte.1959.00270020090010

Travis WD, 2002, Non-Neoplastic Disorders of the Lower Respiratory Tract, 10.55418/1881041794

Winternitz MC, 1920, The Pathology of Influenza

Wolbach SB, 1919, Johns Hopkins Hosp. Bull., 30, 104

10.1016/0046-8177(94)90170-8

10.1016/S0140-6736(04)15595-5

10.1126/science.1090350

10.1056/NEJMp068205

10.1001/jama.297.18.2025

10.1002/1096-9071(200103)63:3<242::AID-JMV1007>3.0.CO;2-N

10.3201/eid1107.041313

10.1038/nm1477

Peiris M, 2006, Novartis Found Symp., 279, 56, 10.1002/9780470035399.ch5

Cent. Dis. Control., 2000, MMWR Morb. Mortal. Wkly. Rep., 49, 375

10.2165/00066982-200106040-00010

10.1056/NEJM200012143432407

10.1098/rstb.2001.0999

10.3201/eid0912.030289

36. World Health Org. 2001. Influenza in the world. 1 October 1999–30 September 2000.Wkly. Epidemiol. Rec.76:49–53

10.1007/978-1-4615-4743-3_6

10.1001/jama.282.1.31

10.1056/NEJMp068030

10.1016/j.antiviral.2006.05.016

Hayden FG, 2006, J. Infect. Dis., 194, S

10.1128/AAC.01339-05

Palese P, 2007, Fields Virology, 1647

10.1126/science.288.5468.1051

Youzbashi E, 1996, Tierarztl. Prax, 24, 337

Webster RG, 1992, Microbiol. Rev., 56, 152, 10.1128/mr.56.1.152-179.1992

10.1126/science.1121586

Smith NM, 2006, MMWR Recomm. Rep., 55, 1

10.1093/molbev/msl102

10.1016/0042-6822(78)90153-8

Kawaoka Y, 1989, J. Virol., 63, 4603, 10.1128/jvi.63.11.4603-4608.1989

10.1073/pnas.031575198

10.1073/pnas.96.4.1651

10.1128/JVI.78.22.12462-12470.2004

10.1128/JVI.76.21.10717-10723.2002

10.1073/pnas.100140097

10.1038/nature04230

10.1038/nrmicro1027

10.1128/JVI.01414-06

10.3201/eid1201.050965

10.3201/eid1201.051007

10.1073/pnas.0308352100

10.3201/eid1012.040961

64. World Health Org. 2007.Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO. Geneva: World Health Org.

10.1056/NEJMoa044021

Jordan EO, 1927, Epidemic Influenza: A Survey

10.1086/515616

Weichselbaum A, 1892, Wiener klinische Wochenschr., 5, 459

10.1007/BF01882006

Askanazy M, 1919, Corr. Bl. Schwiez Aerzte, 49, 465

Opie EL, 1921, Epidemic Respiratory Disease: The Pneumonias and Other Infections of the Respiratory Tract Accompanying Influenza and Measles

MacCallum WG, 1921, Johns Hopkins Hosp. Rep., 20, 149

10.1001/archinte.1919.00090250027002

Opie EL, 1928, Arch. Pathol. Lab. Med., 5, 285

10.1097/00000441-191911000-00012

Klotz O, 1919, Studies on Epidemic Influenza, 207

10.1001/jama.1919.02610210015003

Walker OJ, 1919, J. Lab. Clin. Med., 5, 154

10.1001/archinte.1923.00110220091009

10.1016/S0140-6736(00)78541-2

Taubenberger JK, 2007, Antivir. Ther., 12, 581, 10.1177/135965350701200S02.1

10.1016/S0140-6736(57)92066-4

10.1016/S0140-6736(58)92404-8

Feldman PS, 1972, Yale J. Biol. Med., 45, 49

10.1378/chest.63.4.644

10.1084/jem.54.3.349

10.1084/jem.54.3.373

10.1084/jem.60.1.49

10.1084/jem.62.4.561

Andrewes CH, 1934, J. Exp. Med., 224, 859

10.1002/path.1700830123

10.1038/icb.1941.43

Clements ML, 1986, J. Clin. Microbiol., 24, 47, 10.1128/jcm.24.1.47-51.1986

Snyder MH, 1986, J. Clin. Microbiol., 24, 467, 10.1128/jcm.24.3.467-469.1986

10.1093/infdis/160.4.604

10.1093/infdis/154.2.370-a

10.1093/infdis/154.4.709

98. Baskin CR, Garcia-Sastre A, Tumpey TM, Bielefeldt-Ohmann H, Carter VS, et al. 2004. Integration of clinical data, pathology, and cDNA microarrays in influenza virus-infected pigtailed macaques (Macaca nemestrina).J. Virol.78:10420–32

10.1128/JVI.00851-06

10.1073/pnas.0605134103

10.1128/JVI.79.18.11788-11800.2005

10.1099/vir.0.81843-0

10.1099/0022-1317-81-10-2503

10.1084/jem.20051938

10.1354/vp.40-3-304

Fodor E, 1999, J. Virol., 73, 9679, 10.1128/JVI.73.11.9679-9682.1999

10.1126/science.1119392

10.1038/nature05181

10.1038/nature05495

Thông tin
Thông tin xuất bản

Annual Review of Pathology: Mechanisms of Disease

Tập 3 Số 1

499-522

Thông tin tác giả