The Pathology of Chronic Obstructive Pulmonary Disease: Progress in the 20th and 21st Centuries

Global strategy for the diagnosis, management, and prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) Web site

Mannino, 2003, Chronic obstructive pulmonary disease: definition and epidemiology, Respir Care, 48, 1185

Snider, 1992, Emphysema: the first two centuries - and beyond (part 1), Am Rev Respir Dis, 146, 1334, 10.1164/ajrccm/146.5_Pt_1.1334

Snider, 1992, Emphysema: the first two centuries - and beyond (part 2), Am Rev Respir Dis, 146, 1615, 10.1164/ajrccm/146.6.1615

Gough, 1952, Discussion on the diagnosis of pulmonary emphysema: the pathological diagnosis of emphysema, Proc R Soc Med, 45, 576

McLean, 1957, The histology of generalized pulmonary emphysema: the genesis of the early centrilobular lesion: focal emphysema, Australas Ann Med, 6, 124, 10.1111/imj.1957.6.2.124

McLean, 1956, The pathology of acute bronchiolitis–a study of its evolution, I: the exudative phase, Australas Ann Med, 5, 254, 10.1111/imj.1956.5.4.254

McLean, 1957, The pathology of acute bronchiolitis - a study of its evolution, II: the repair phase, Australas Ann Med, 6, 29, 10.1111/imj.1957.6.1.29

McLean, 1958, The significance of pulmonary vascular changes in emphysema, Australas Ann Med, 7, 69, 10.1111/imj.1958.7.1.69

Snider, 1985, The definition of emphysema: report of a National Heart, Lung, and Blood Institute Division of Lung Diseases workshop, Am Rev Respir Dis, 132, 182

Thurlbeck, 1970, A comparison of three methods of measuring emphysema, Hum Pathol, 1, 215, 10.1016/S0046-8177(70)80035-1

Lynch, 2015, CT-definable subtypes of chronic obstructive pulmonary disease: a statement of the Fleischner Society, Radiology, 277, 192, 10.1148/radiol.2015141579

Churg, 2010, Respiratory bronchiolitis/interstitial lung disease: fibrosis, pulmonary function, and evolving concepts, Arch Pathol Lab Med, 134, 27, 10.5858/134.1.27

Thurlbeck WM, Wright JL. Thurlbeck's Chronic Airflow Obstruction. 2nd ed.Hamilton, ON: B.C. Decker; 1999.

Hogg, 1968, Site and nature of airway obstruction in chronic obstructive lung disease, N Engl J Med, 278, 1355, 10.1056/NEJM196806202782501

Cosio, 1977, The relations between structural changes in small airways and pulmonary-function tests, N Engl J Med, 298, 1277, 10.1056/NEJM197806082982303

Wright, 1984, The detection of small airways disease, Am Rev Respir Dis, 129, 989

McDonough, 2011, Small-airway obstruction and emphysema in chronic obstructive pulmonary disease, N Engl J Med, 365, 1567, 10.1056/NEJMoa1106955

Traver, 1979, Predictors of mortality in chronic obstructive pulmonary disease, Am Rev Respir Dis, 119, 895

Celli, 2006, Chronic obstructive pulmonary disease: from unjustified nihilism to evidence-based optimism, Proc Am Thorac Soc, 3, 58, 10.1513/pats.200510-111JH

Weitzenblum, 1981, Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease, Thorax, 36, 752, 10.1136/thx.36.10.752

Wright, 2005, Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment, Thorax, 60, 605, 10.1136/thx.2005.042994

Peinado, 2008, Pulmonary vascular involvement in COPD, Chest, 134, 808, 10.1378/chest.08-0820

Budhiraja, 2004, Endothelial dysfunction in pulmonary hypertension, Circulation, 109, 159, 10.1161/01.CIR.0000102381.57477.50

Kiowski, 1994, Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers, Circulation, 90, 27, 10.1161/01.CIR.90.1.27

Dinh-Xuan, 1991, Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease, N Engl J Med, 324, 1539, 10.1056/NEJM199105303242203

Dinh-Xuan, 1993, Impairment of pulmonary-artery endothelium-dependent relaxation in chronic obstructive lung disease is not due to dysfunction of endothelial cell membrane receptors nor to L-arginine deficiency, Br J Pharmacol, 109, 587, 10.1111/j.1476-5381.1993.tb13611.x

Giaid, 1995, Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension, N Engl J Med, 333, 214, 10.1056/NEJM199507273330403

Cottin, 2005, Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity, Eur Respir J, 26, 586, 10.1183/09031936.05.00021005

Wright, 2011, Fibrosis with emphysema, Histopathology, 58, 517, 10.1111/j.1365-2559.2010.03648.x

Kawabata, 2008, Smoking-related changes in the background lung of specimens resected for lung cancer: a semiquantitative study with correlation to postoperative course, Histopathology, 53, 707, 10.1111/j.1365-2559.2008.03183.x

Wright, 2007, Current concepts in mechanisms of emphysema, Toxicol Pathol, 35, 111, 10.1080/01926230601059951

Bagdonas, 2015, Novel aspects of pathogenesis and regeneration mechanisms in COPD, Int J COPD, 10, 995

Sze, 2015, Host response to the lung microbiome in chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 192, 438, 10.1164/rccm.201502-0223OC

Cho, 2015, A genome-wide association study of emphysema and airway quantitative imagin phenotypes, Am J Respir Crit Care Med, 192, 559, 10.1164/rccm.201501-0148OC

Lee, 2014, Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene, Respir Med, 108, 1469, 10.1016/j.rmed.2014.07.018

Footitt, 2016, Oxidative and nitrosative stress and histone deacetylase-2 activity in exacerbations of chronic obstructive pulmonary disease, Chest, 149, 62, 10.1378/chest.14-2637